Detalhe da pesquisa
1.
ROR1 targeting with the antibody-drug conjugate VLS-101 is effective in Richter syndrome patient-derived xenograft mouse models.
Blood
; 137(24): 3365-3377, 2021 06 17.
Artigo
Inglês
| MEDLINE | ID: mdl-33512452
2.
Acalabrutinib (ACP-196) in Relapsed Chronic Lymphocytic Leukemia.
N Engl J Med
; 374(4): 323-32, 2016 Jan 28.
Artigo
Inglês
| MEDLINE | ID: mdl-26641137
3.
PI3K p110δ uniquely promotes gain-of-function Shp2-induced GM-CSF hypersensitivity in a model of JMML.
Blood
; 123(18): 2838-42, 2014 May 01.
Artigo
Inglês
| MEDLINE | ID: mdl-24553178
4.
Idelalisib, an inhibitor of phosphatidylinositol 3-kinase p110δ, for relapsed/refractory chronic lymphocytic leukemia.
Blood
; 123(22): 3390-7, 2014 May 29.
Artigo
Inglês
| MEDLINE | ID: mdl-24615777
5.
Effects of isoform-selective phosphatidylinositol 3-kinase inhibitors on osteoclasts: actions on cytoskeletal organization, survival, and resorption.
J Biol Chem
; 288(49): 35346-57, 2013 Dec 06.
Artigo
Inglês
| MEDLINE | ID: mdl-24133210
6.
PI3Kδ inhibitor, GS-1101 (CAL-101), attenuates pathway signaling, induces apoptosis, and overcomes signals from the microenvironment in cellular models of Hodgkin lymphoma.
Blood
; 119(8): 1897-900, 2012 Feb 23.
Artigo
Inglês
| MEDLINE | ID: mdl-22210877
7.
Decreased mitochondrial apoptotic priming underlies stroma-mediated treatment resistance in chronic lymphocytic leukemia.
Blood
; 120(17): 3501-9, 2012 Oct 25.
Artigo
Inglês
| MEDLINE | ID: mdl-22955911
8.
The phosphatidylinositol 3-kinases (PI3K) inhibitor GS-1101 synergistically potentiates histone deacetylase inhibitor-induced proliferation inhibition and apoptosis through the inactivation of PI3K and extracellular signal-regulated kinase pathways.
Br J Haematol
; 163(1): 72-80, 2013 Oct.
Artigo
Inglês
| MEDLINE | ID: mdl-23889282
9.
The role of phosphatidylinositol 3-kinase-δ in the immunomodulatory effects of lenalidomide in chronic lymphocytic leukemia.
Blood
; 117(16): 4323-7, 2011 Apr 21.
Artigo
Inglês
| MEDLINE | ID: mdl-21378270
10.
The phosphoinositide 3'-kinase delta inhibitor, CAL-101, inhibits B-cell receptor signaling and chemokine networks in chronic lymphocytic leukemia.
Blood
; 118(13): 3603-12, 2011 Sep 29.
Artigo
Inglês
| MEDLINE | ID: mdl-21803855
11.
CAL-101, a p110delta selective phosphatidylinositol-3-kinase inhibitor for the treatment of B-cell malignancies, inhibits PI3K signaling and cellular viability.
Blood
; 117(2): 591-4, 2011 Jan 13.
Artigo
Inglês
| MEDLINE | ID: mdl-20959606
12.
Phosphatidylinositol 3-kinase-δ inhibitor CAL-101 shows promising preclinical activity in chronic lymphocytic leukemia by antagonizing intrinsic and extrinsic cellular survival signals.
Blood
; 116(12): 2078-88, 2010 Sep 23.
Artigo
Inglês
| MEDLINE | ID: mdl-20522708
13.
PI3K/p110{delta} is a novel therapeutic target in multiple myeloma.
Blood
; 116(9): 1460-8, 2010 Sep 02.
Artigo
Inglês
| MEDLINE | ID: mdl-20505158
14.
Zilovertamab Vedotin Targeting of ROR1 as Therapy for Lymphoid Cancers.
NEJM Evid
; 1(1): EVIDoa2100001, 2022 01.
Artigo
Inglês
| MEDLINE | ID: mdl-38319241
15.
Incomplete restoration of Mpl expression in the mpl-/- mouse produces partial correction of the stem cell-repopulating defect and paradoxical thrombocytosis.
Blood
; 113(8): 1778-85, 2009 Feb 19.
Artigo
Inglês
| MEDLINE | ID: mdl-18796624
16.
The antibody drug conjugate VLS-101 targeting ROR1 is effective in CAR T-resistant mantle cell lymphoma.
J Hematol Oncol
; 14(1): 132, 2021 08 28.
Artigo
Inglês
| MEDLINE | ID: mdl-34454548
17.
Putative roles for PI3K α and δ isoforms in refractory mantle cell lymphoma.
Acta Haematol
; 131(4): 218-9, 2014.
Artigo
Inglês
| MEDLINE | ID: mdl-24296619
18.
Expression of the GPI-anchored receptor Prv-1 enhances thrombopoietin and IL-3-induced proliferation in hematopoietic cell lines.
Leuk Res
; 32(5): 811-9, 2008 May.
Artigo
Inglês
| MEDLINE | ID: mdl-17980909
19.
Combined BTK and PI3Kδ Inhibition with Acalabrutinib and ACP-319 Improves Survival and Tumor Control in CLL Mouse Model.
Clin Cancer Res
; 23(19): 5814-5823, 2017 Oct 01.
Artigo
Inglês
| MEDLINE | ID: mdl-28645939
20.
PI3Kγ/δ and NOTCH1 Cross-Regulate Pathways That Define the T-cell Acute Lymphoblastic Leukemia Disease Signature.
Mol Cancer Ther
; 16(10): 2069-2082, 2017 10.
Artigo
Inglês
| MEDLINE | ID: mdl-28716817