Studying the General Toxicity and Cumulative Properties of a Radiopharmaceutical Nanocolloid, (99m)Tc-Al2O3.

We studied toxicity of a new Russian radiopharmaceutical Nanocolloid, (99m)Tc-Al2O3. Tests for acute toxicity showed that this agent belongs to a class of moderate-toxicity substances and does not have cumulative properties. The evaluation of subchronic toxicity after subcutaneous injection of this product to rats (0.04, 0.2, and 0.4 ml/kg) and rabbits (0.02 and 0.2 ml/kg) for 7 days did not reveal changes in the general state, temperature, body weight, indices of the peripheral blood and bone marrow, functions of the heart, liver, kidneys, and nervous system, and morphological characteristics of the internal organs in animals. The drug does not produce a local irritant effect.

[Unification of medical instruments and evaluation of its level]. / Nekotorye osobennosti unifikatsii meditsinskikh instrumentov i otsenki ee urovnia.

Consideration is given to the general methodologic approach to unify medical instruments. It is based on an analysis of specific parameters of medical instruments to be unified and on characteristics of medical instrumentation production. The technique of calculating the unification level for an individual product and for a group of uniform products is demonstrated as exemplified by medical forceps.