Detalhe da pesquisa
1.
Active site profiling reveals coupling between domains in SRC-family kinases.
Nat Chem Biol
; 9(1): 43-50, 2013 Jan.
Artigo
Inglês
| MEDLINE | ID: mdl-23143416
2.
Structural basis for type VI secretion effector recognition by a cognate immunity protein.
PLoS Pathog
; 8(4): e1002613, 2012.
Artigo
Inglês
| MEDLINE | ID: mdl-22511866
3.
Structure of the prolyl-tRNA synthetase from the eukaryotic pathogen Giardia lamblia.
Acta Crystallogr D Biol Crystallogr
; 68(Pt 9): 1194-200, 2012 Sep.
Artigo
Inglês
| MEDLINE | ID: mdl-22948920
4.
Affinity-based probes based on type II kinase inhibitors.
J Am Chem Soc
; 134(46): 19017-25, 2012 Nov 21.
Artigo
Inglês
| MEDLINE | ID: mdl-23088519
5.
Benzoylbenzimidazole-based selective inhibitors targeting Cryptosporidium parvum and Toxoplasma gondii calcium-dependent protein kinase-1.
Bioorg Med Chem Lett
; 22(16): 5264-7, 2012 Aug 15.
Artigo
Inglês
| MEDLINE | ID: mdl-22795629
6.
Monitoring GAPDH activity and inhibition with cysteine-reactive chemical probes.
RSC Chem Biol
; 3(7): 972-982, 2022 Jul 06.
Artigo
Inglês
| MEDLINE | ID: mdl-35866162
7.
Prediction of protein crystallization outcome using a hybrid method.
J Struct Biol
; 171(1): 64-73, 2010 Jul.
Artigo
Inglês
| MEDLINE | ID: mdl-20347992
8.
Toxoplasma gondii cathepsin L is the primary target of the invasion-inhibitory compound morpholinurea-leucyl-homophenyl-vinyl sulfone phenyl.
J Biol Chem
; 284(39): 26839-50, 2009 Sep 25.
Artigo
Inglês
| MEDLINE | ID: mdl-19596863
9.
X-ray crystal structure localizes the mechanism of inhibition of an IL-36R antagonist monoclonal antibody to interaction with Ig1 and Ig2 extra cellular domains.
Protein Sci
; 29(7): 1679-1686, 2020 07.
Artigo
Inglês
| MEDLINE | ID: mdl-32239732
10.
Inexpensive robotic system for standard and fluorescent imaging of protein crystals.
Acta Crystallogr F Struct Biol Commun
; 75(Pt 11): 673-686, 2019 Nov 01.
Artigo
Inglês
| MEDLINE | ID: mdl-31702581
11.
Development of Toxoplasma gondii calcium-dependent protein kinase 1 (TgCDPK1) inhibitors with potent anti-toxoplasma activity.
J Med Chem
; 55(5): 2416-26, 2012 Mar 08.
Artigo
Inglês
| MEDLINE | ID: mdl-22320388
12.
Multiple determinants for selective inhibition of apicomplexan calcium-dependent protein kinase CDPK1.
J Med Chem
; 55(6): 2803-10, 2012 Mar 22.
Artigo
Inglês
| MEDLINE | ID: mdl-22369268
13.
Transmission of malaria to mosquitoes blocked by bumped kinase inhibitors.
J Clin Invest
; 122(6): 2301-5, 2012 Jun.
Artigo
Inglês
| MEDLINE | ID: mdl-22565309
14.
Structure of Leishmania major methionyl-tRNA synthetase in complex with intermediate products methionyladenylate and pyrophosphate.
Biochimie
; 93(3): 570-82, 2011 Mar.
Artigo
Inglês
| MEDLINE | ID: mdl-21144880
15.
The double-length tyrosyl-tRNA synthetase from the eukaryote Leishmania major forms an intrinsically asymmetric pseudo-dimer.
J Mol Biol
; 409(2): 159-76, 2011 Jun 03.
Artigo
Inglês
| MEDLINE | ID: mdl-21420975
16.
Discovery of Potent and Selective Inhibitors of Calcium-Dependent Protein Kinase 1 (CDPK1) from C. parvum and T. gondii.
ACS Med Chem Lett
; 1(7): 331-335, 2010 Oct 14.
Artigo
Inglês
| MEDLINE | ID: mdl-21116453
17.
Crystal structure of the aspartyl-tRNA synthetase from Entamoeba histolytica.
Mol Biochem Parasitol
; 169(2): 95-100, 2010 Feb.
Artigo
Inglês
| MEDLINE | ID: mdl-19874856
18.
Crystal structures of trypanosomal histidyl-tRNA synthetase illuminate differences between eukaryotic and prokaryotic homologs.
J Mol Biol
; 397(2): 481-94, 2010 Mar 26.
Artigo
Inglês
| MEDLINE | ID: mdl-20132829
19.
Toxoplasma gondii calcium-dependent protein kinase 1 is a target for selective kinase inhibitors.
Nat Struct Mol Biol
; 17(5): 602-7, 2010 May.
Artigo
Inglês
| MEDLINE | ID: mdl-20436472
20.
The crystal structure and activity of a putative trypanosomal nucleoside phosphorylase reveal it to be a homodimeric uridine phosphorylase.
J Mol Biol
; 396(5): 1244-59, 2010 Mar 12.
Artigo
Inglês
| MEDLINE | ID: mdl-20070944