Anti-SARS-CoV-2 IgG antibodies induced by the BNT162b2 mRNA vaccine is age-dependent and influenced by a previous natural SARS-CoV-2 infection.

BACKGROUND AND AIM: our study aimed to investigate the association between anti-SARS-CoV-2 IgG level after two doses of BNT162b2 vaccine and the previously infected/infection-naïve status, age, and gender in a population of health care workers (HCWs). METHODS: all the population of immunocompetent HCWs were vaccinated with two doses of BNT162b2 based on a technical data sheet. SARS-CoV-2 IgG assay was performed 25 to 32 days after the second dose. Anti-SARS-CoV-2 IgG level was used as a categorical variable, since 2080 BAU/ml was the median IgG value. The multivariate logistic regression model included the previously infected/infection-naïve status, age groups, and gender. RESULTS: All HCWs tested were seropositive. The odds ratio (OR) for anti-SARS-CoV-2 IgG> 2080 BAU / ml between previously infected and infection-naïve HCWs was 2.05 [95% CI 1.1-3.8].  Older age groups had lower percentage of HCWs with anti-SARS-CoV-2 IgG> 2080 BAU / mL than younger groups. Finally, no association between gender and IgG level was found. CONCLUSIONS: our study showed an excellent antibody response to vaccination with BNT162b2 after two doses. A significant difference was observed between anti-SARS-CoV-2 IgG level with age and previous SARS-CoV-2 infection status.

["Work related stress" and health care: clinical cases and work-fitness" evaluation]. / Stress lavoro-correlato nel personale ospedaliero: quadri clinici e idoneità lavorative.

In the last years an increasing number of people is coming in observation at the Hospital Units of Occupational Medicine in Lombardia, with several "work related stress diseases", showing various clinical manifestations, from light depressive syndromes to severe psychiatric pathologies. Since 1994 the occupational physicians in Lombardia are involved in the "stress related problems" at the workplaces (see SIMLII Symposium in Milan). Furthermore, a specific research project in the years 2004-2007 describes the real dimension of the problem in the different production fields in Lombardia. After the recent Symposium about stress factors at work (2009, the 04 April, Monza, University of Milan Bicocca) an Occupational Medicine Network has been formed, with the purpose to collect and to compare the clinical data of the people coming in observation, by using for this aim a specific data collection grid. The first considerations were presented during the SIMLII Congress 2009 in Florence. Now in the present text the authors describe the collected data about 50 clinical cases employed in health care and hospital activities. At last, the real purpose of the authors is to show the correct proceedings for oriented action levels in the work organization, and for a good management of the specific clinical cases, trough the experiences of the Occupational Medicine Units of Desio and Monza.

[Training and information interventions aimed at stress control in the health care sector: potentialities and limits]. / Interventi di informazione e formazione per il controllo dello stress in ambito sanitario: punti di forza e limiti.

Training programs for health care workers aimed at controlling job-related stress (person-directed, person-work interface and organizational interventions) demonstrate only short-term effect in reducing stress levels. Medium-long-term results could be achieved only through well-articulated programs, which involve health administration managers and nursing staff in a solid and enduring prevention-centered approach. Informative interventions conducted in hospital for preventing job-related stress have a particularly good response rate among nurses and other members of medical support and technical staff. Physicians don't seem to respond to these interventions since they have more decision-making autonomy and develop reward mechanisms; for these reasons, they feel to have less need for training/support interventions. Finally, our results confirm the need for a more-active stress management policy in hospitals and other health care institutions.