1.
Bioorg Med Chem Lett
; 18(2): 464-8, 2008 Jan 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-18178084
RESUMO
The synthesis and gamma-secretase inhibition data for a series of carbamate-appended N-alkylsulfonamides are described. Carbamate 54 was found to significantly reduce brain Abeta in transgenic mice. 54 was also found to possess markedly improved brain levels in transgenic mice compared to previously disclosed 1 and 2.