Pharmacobezoar After Venlafaxine and Oxazepam Overdose: How Pharmacokinetics Could Help?-A Grand Round.

ABSTRACT: The authors present here a case of a pharmacobezoar after drug overdose, diagnosed using multiple blood samples for TDM. This grand round highlights the importance of a dialog between a clinician and a TDM consultant for the optimal care of a patient.

Integrate, yes, but what and how? A computational approach of sensorimotor fusion in speech.

We consider a computational model comparing the possible roles of "association" and "simulation" in phonetic decoding, demonstrating that these two routes can contain similar information in some "perfect" communication situations and highlighting situations where their decoding performance differs. We conclude that optimal decoding should involve some sort of fusion of association and simulation in the human brain.

Long-term outcomes of COVID-19 intensive care unit survivors and their family members: a one year follow-up prospective study.

Purpose: To describe the long-term physical, functional and mental status of COVID-19 intensive care unit (ICU) patients and their family members 1 year after ICU discharge. Methods: We performed a prospective observational cohort study among patients admitted to the ICU for COVID-19-associated respiratory failure and their family members. Patients attended a one-year follow-up consultation with family members. Physical, functional and respiratory outcomes were collected. In addition, participants completed the Hospital Anxiety and Depression Scale and the Revised Impact of Event Scale. Qualitative components were collected during a 2-h face-to-face interview. Results: Fifty-four patients and 42 family members were included. Thirty-four (63%) patients reported chronic fatigue and 37 (68.5%) dyspnea. Computed tomography scans were abnormal in 34 patients (72.3%). Anxiety symptoms were present in 23 (48%) patients and 26 (66%) family members, depression in 11 (23%) and 13 (33%), and post-traumatic stress disorder in 12 (25%) and 23 (55%), respectively. Visit limitation was reported as the most painful experience for family members. Numerous patients recalled nightmares that contributed to the anxiety. Long-term reconstruction was difficult for both patients and family members. Conclusion: The vast majority of patients and their relatives reported long-term consequences on various physical and mental components, leading to a profound impact on their well-being.

The complementary roles of auditory and motor information evaluated in a Bayesian perceptuo-motor model of speech perception.

There is a consensus concerning the view that both auditory and motor representations intervene in the perceptual processing of speech units. However, the question of the functional role of each of these systems remains seldom addressed and poorly understood. We capitalized on the formal framework of Bayesian Programming to develop COSMO (Communicating Objects using Sensory-Motor Operations), an integrative model that allows principled comparisons of purely motor or purely auditory implementations of a speech perception task and tests the gain of efficiency provided by their Bayesian fusion. Here, we show 3 main results: (a) In a set of precisely defined "perfect conditions," auditory and motor theories of speech perception are indistinguishable; (b) When a learning process that mimics speech development is introduced into COSMO, it departs from these perfect conditions. Then auditory recognition becomes more efficient than motor recognition in dealing with learned stimuli, while motor recognition is more efficient in adverse conditions. We interpret this result as a general "auditory-narrowband versus motor-wideband" property; and (c) Simulations of plosive-vowel syllable recognition reveal possible cues from motor recognition for the invariant specification of the place of plosive articulation in context that are lacking in the auditory pathway. This provides COSMO with a second property, where auditory cues would be more efficient for vowel decoding and motor cues for plosive articulation decoding. These simulations provide several predictions, which are in good agreement with experimental data and suggest that there is natural complementarity between auditory and motor processing within a perceptuo-motor theory of speech perception. (PsycINFO Database Record