Detalhe da pesquisa
1.
Induction of hemangiosarcoma in mice after chronic treatment with S1P-modulator siponimod and its lack of relevance to rat and human.
Arch Toxicol
; 92(5): 1877-1891, 2018 05.
Artigo
Inglês
| MEDLINE | ID: mdl-29556671
2.
Sphingosine 1-Phosphate Produced by Sphingosine Kinase 2 Intrinsically Controls Platelet Aggregation In Vitro and In Vivo.
Circ Res
; 117(4): 376-87, 2015 Jul 31.
Artigo
Inglês
| MEDLINE | ID: mdl-26129975
3.
Reduced Activity of Sphingosine-1-Phosphate Lyase Induces Podocyte-related Glomerular Proteinuria, Skin Irritation, and Platelet Activation.
Toxicol Pathol
; 43(5): 694-703, 2015 Jul.
Artigo
Inglês
| MEDLINE | ID: mdl-25630683
4.
A root cause analysis to identify the mechanistic drivers of immunogenicity against the anti-VEGF biotherapeutic brolucizumab.
Sci Transl Med
; 15(681): eabq5068, 2023 02.
Artigo
Inglês
| MEDLINE | ID: mdl-36724241
5.
Effects of hepatic drug-metabolizing enzyme induction on clinical pathology parameters in animals and man.
Toxicol Pathol
; 38(5): 810-28, 2010 Aug.
Artigo
Inglês
| MEDLINE | ID: mdl-20585144
6.
International recommendations for training future toxicologic pathologists participating in regulatory-type, nonclinical toxicity studies.
Toxicol Pathol
; 38(6): 984-92, 2010 Oct.
Artigo
Inglês
| MEDLINE | ID: mdl-20716784
7.
Pharmacological Inhibition of MALT1 Protease Leads to a Progressive IPEX-Like Pathology.
Front Immunol
; 11: 745, 2020.
Artigo
Inglês
| MEDLINE | ID: mdl-32425939
8.
Detection of reticulated platelets in whole blood of rats using flow cytometry.
Exp Toxicol Pathol
; 60(6): 443-8, 2008 Sep.
Artigo
Inglês
| MEDLINE | ID: mdl-18603417
9.
A combined approach to early detect in vitro drug-induced hemostatic changes in preclinical safety.
Exp Toxicol Pathol
; 69(5): 275-283, 2017 Jun 14.
Artigo
Inglês
| MEDLINE | ID: mdl-28190562
10.
Editor's Highlight: Comparative Renal Safety Assessment of the Hepatitis B Drugs, Adefovir, Tenofovir, Telbivudine and Entecavir in Rats.
Toxicol Sci
; 155(1): 283-297, 2017 01.
Artigo
Inglês
| MEDLINE | ID: mdl-27742868
11.
Acute megakaryoblastic leukemia with erythrophagocytosis and thrombosis in a dog.
Vet Clin Pathol
; 34(1): 52-6, 2005.
Artigo
Inglês
| MEDLINE | ID: mdl-15732019
12.
Renal studies in safety pharmacology and toxicology: A survey conducted in the top 15 pharmaceutical companies.
J Pharmacol Toxicol Methods
; 75: 101-10, 2015.
Artigo
Inglês
| MEDLINE | ID: mdl-25637943
13.
Characterization of bone turnover and energy metabolism in a rat model of primary and secondary osteoporosis.
Exp Toxicol Pathol
; 67(4): 287-96, 2015 Apr.
Artigo
Inglês
| MEDLINE | ID: mdl-25773704
14.
Prognostic significance of morphological subtypes in canine malignant lymphomas during chemotherapy.
Vet J
; 167(2): 158-66, 2004 Mar.
Artigo
Inglês
| MEDLINE | ID: mdl-14975390
15.
Optimization of Multiplate(®) whole blood platelet aggregometry in the Beagle dog and Wistar rat for ex vivo drug toxicity testing.
Exp Toxicol Pathol
; 65(5): 637-44, 2013 Jul.
Artigo
Inglês
| MEDLINE | ID: mdl-22884258
16.
Preclinical evaluation of potential nilotinib cardiotoxicity.
Leuk Res
; 35(5): 631-7, 2011 May.
Artigo
Inglês
| MEDLINE | ID: mdl-21129774
17.
International recommendations for training future toxicologic pathologists participating in regulatory-type, nonclinical toxicity studies.
Exp Toxicol Pathol
; 63(1-2): 187-95, 2011 Jan.
Artigo
Inglês
| MEDLINE | ID: mdl-20724123
18.
Sublingual and submandibular blood collection in mice: a comparison of effects on body weight, food consumption and tissue damage.
Lab Anim
; 44(4): 352-8, 2010 Oct.
Artigo
Inglês
| MEDLINE | ID: mdl-20696790
19.
Imatinib does not induce cardiotoxicity at clinically relevant concentrations in preclinical studies.
Leuk Res
; 34(9): 1180-8, 2010 Sep.
Artigo
Inglês
| MEDLINE | ID: mdl-20122731
20.
International recommendations for training future toxicologic pathologists participating in regulatory-type, nonclinical toxicity studies.
J Toxicol Pathol
; 23(3): 171-81, 2010 Sep.
Artigo
Inglês
| MEDLINE | ID: mdl-22272030