Detalhe da pesquisa
1.
Biological and Structural Analyses of New Potent Allosteric Inhibitors of HIV-1 Integrase.
Antimicrob Agents Chemother
; 67(7): e0046223, 2023 07 18.
Artigo
Inglês
| MEDLINE | ID: mdl-37310224
2.
Structure-function analyses unravel distinct effects of allosteric inhibitors of HIV-1 integrase on viral maturation and integration.
J Biol Chem
; 293(16): 6172-6186, 2018 04 20.
Artigo
Inglês
| MEDLINE | ID: mdl-29507092
3.
The HIV-1 integrase-LEDGF allosteric inhibitor MUT-A: resistance profile, impairment of virus maturation and infectivity but without influence on RNA packaging or virus immunoreactivity.
Retrovirology
; 14(1): 50, 2017 11 09.
Artigo
Inglês
| MEDLINE | ID: mdl-29121950
4.
Dual inhibition of HIV-1 replication by integrase-LEDGF allosteric inhibitors is predominant at the post-integration stage.
Retrovirology
; 10: 144, 2013 Nov 21.
Artigo
Inglês
| MEDLINE | ID: mdl-24261564
5.
Structural Basis for E. coli Penicillin Binding Protein (PBP) 2 Inhibition, a Platform for Drug Design.
J Med Chem
; 62(9): 4742-4754, 2019 05 09.
Artigo
Inglês
| MEDLINE | ID: mdl-30995398
6.
Discovery of (3S)-amino-(4R)-ethylpiperidinyl quinolones as potent antibacterial agents with a broad spectrum of activity and activity against resistant pathogens.
J Med Chem
; 46(17): 3655-61, 2003 Aug 14.
Artigo
Inglês
| MEDLINE | ID: mdl-12904069
7.
Non-fluorinated quinolones (NFQs): new antibacterials with unique properties against quinolone-resistant gram-positive pathogens.
Curr Drug Targets Infect Disord
; 2(1): 51-65, 2002 Mar.
Artigo
Inglês
| MEDLINE | ID: mdl-12462153
8.
Synthesis of trans-(3S)-amino-(4R)-alkyl- and -(4S)-aryl-piperidines via ring-closing metathesis reaction.
Org Lett
; 4(25): 4499-502, 2002 Dec 12.
Artigo
Inglês
| MEDLINE | ID: mdl-12465922
9.
Vectorization efforts to increase Gram-negative intracellular drug concentration: a case study on HldE-K inhibitors.
J Med Chem
; 56(5): 1908-21, 2013 Mar 14.
Artigo
Inglês
| MEDLINE | ID: mdl-23445125
10.
Synthesis and biological testing of non-fluorinated analogues of levofloxacin.
Bioorg Med Chem Lett
; 13(14): 2373-5, 2003 Jul 21.
Artigo
Inglês
| MEDLINE | ID: mdl-12824037
11.
Unique biological properties and molecular mechanism of 5,6-bridged quinolones.
Antimicrob Agents Chemother
; 47(8): 2526-37, 2003 Aug.
Artigo
Inglês
| MEDLINE | ID: mdl-12878515