Detalhe da pesquisa
1.
Dual inhibition of αvß6 and αvß1 reduces fibrogenesis in lung tissue explants from patients with IPF.
Respir Res
; 22(1): 265, 2021 Oct 19.
Artigo
Inglês
| MEDLINE | ID: mdl-34666752
2.
Discovery of BI 135585, an in vivo efficacious oxazinanone-based 11ß hydroxysteroid dehydrogenase type 1 inhibitor.
Bioorg Med Chem
; 25(14): 3649-3657, 2017 07 15.
Artigo
Inglês
| MEDLINE | ID: mdl-28528082
3.
Brain penetrant liver X receptor (LXR) modulators based on a 2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole core.
Bioorg Med Chem Lett
; 26(20): 5044-5050, 2016 10 15.
Artigo
Inglês
| MEDLINE | ID: mdl-27599745
4.
Identification of spirooxindole and dibenzoxazepine motifs as potent mineralocorticoid receptor antagonists.
Bioorg Med Chem
; 24(6): 1384-91, 2016 Mar 15.
Artigo
Inglês
| MEDLINE | ID: mdl-26897089
5.
Purine derivatives as potent Bruton's tyrosine kinase (BTK) inhibitors for autoimmune diseases.
Bioorg Med Chem Lett
; 24(9): 2206-11, 2014 May 01.
Artigo
Inglês
| MEDLINE | ID: mdl-24685542
6.
Empowering Voices: Inspiring Women in Medicinal Chemistry.
J Med Chem
; 67(6): 4251-4258, 2024 Mar 28.
Artigo
Inglês
| MEDLINE | ID: mdl-38456628
7.
Empowering Voices: Inspiring Women in Medicinal Chemistry.
ACS Med Chem Lett
; 15(4): 424-431, 2024 Apr 11.
Artigo
Inglês
| MEDLINE | ID: mdl-38628790
8.
Synthesis and evaluation of carbamoylmethylene linked prodrugs of BMS-582949, a clinical p38α inhibitor.
Bioorg Med Chem Lett
; 23(10): 3028-33, 2013 May 15.
Artigo
Inglês
| MEDLINE | ID: mdl-23578688
9.
The identification of novel p38α isoform selective kinase inhibitors having an unprecedented p38α binding mode.
Bioorg Med Chem Lett
; 23(14): 4120-6, 2013 Jul 15.
Artigo
Inglês
| MEDLINE | ID: mdl-23746475
10.
Enhancing the Visibility of Women in the ACS Division of Medicinal Chemistry (ACS MEDI).
J Med Chem
; 66(6): 3651-3655, 2023 03 23.
Artigo
Inglês
| MEDLINE | ID: mdl-36884261
11.
Enhancing the Visibility of Women in the ACS Division of Medicinal Chemistry (ACS MEDI).
ACS Med Chem Lett
; 14(4): 345-349, 2023 Apr 13.
Artigo
Inglês
| MEDLINE | ID: mdl-37077389
12.
Discovery of pyrrolo[2,1-f][1,2,4]triazine C6-ketones as potent, orally active p38α MAP kinase inhibitors.
Bioorg Med Chem Lett
; 21(15): 4633-7, 2011 Aug 01.
Artigo
Inglês
| MEDLINE | ID: mdl-21705217
13.
Structure-Guided Optimization Provides a Series of TTK Protein Inhibitors with Potent Antitumor Activity.
J Med Chem
; 64(17): 12670-12679, 2021 09 09.
Artigo
Inglês
| MEDLINE | ID: mdl-34459599
14.
Discovery of the Selective Protein Kinase C-θ Kinase Inhibitor, CC-90005.
J Med Chem
; 64(16): 11886-11903, 2021 08 26.
Artigo
Inglês
| MEDLINE | ID: mdl-34355886
15.
Utilization of a nitrogen-sulfur nonbonding interaction in the design of new 2-aminothiazol-5-yl-pyrimidines as p38α MAP kinase inhibitors.
Bioorg Med Chem Lett
; 20(19): 5864-8, 2010 Oct 01.
Artigo
Inglês
| MEDLINE | ID: mdl-20732813
16.
5-amino-pyrazoles as potent and selective p38α inhibitors.
Bioorg Med Chem Lett
; 20(23): 6886-9, 2010 Dec 01.
Artigo
Inglês
| MEDLINE | ID: mdl-21035336
17.
Discovery and optimization of adamantyl carbamate inhibitors of 11ß-HSD1.
Bioorg Med Chem Lett
; 20(22): 6725-9, 2010 Nov 15.
Artigo
Inglês
| MEDLINE | ID: mdl-20864344
18.
Insights into Protein-Ligand Interactions in Integrin Complexes: Advances in Structure Determinations.
J Med Chem
; 63(11): 5675-5696, 2020 06 11.
Artigo
Inglês
| MEDLINE | ID: mdl-31999923
19.
Discovery of CRBN E3 Ligase Modulator CC-92480 for the Treatment of Relapsed and Refractory Multiple Myeloma.
J Med Chem
; 63(13): 6648-6676, 2020 07 09.
Artigo
Inglês
| MEDLINE | ID: mdl-32130004
20.
Design and Optimization Leading to an Orally Active TTK Protein Kinase Inhibitor with Robust Single Agent Efficacy.
J Med Chem
; 62(9): 4401-4410, 2019 05 09.
Artigo
Inglês
| MEDLINE | ID: mdl-30998356