Detalhe da pesquisa
1.
Branched chain amino acid metabolism profiles in progressive human nonalcoholic fatty liver disease.
Amino Acids
; 47(3): 603-15, 2015 Mar.
Artigo
Inglês
| MEDLINE | ID: mdl-25534430
2.
Characterization of hepatocellular carcinoma related genes and metabolites in human nonalcoholic fatty liver disease.
Dig Dis Sci
; 59(2): 365-74, 2014 Feb.
Artigo
Inglês
| MEDLINE | ID: mdl-24048683
3.
Decreased hepatotoxic bile acid composition and altered synthesis in progressive human nonalcoholic fatty liver disease.
Toxicol Appl Pharmacol
; 268(2): 132-40, 2013 Apr 15.
Artigo
Inglês
| MEDLINE | ID: mdl-23391614
4.
Bicyclic Ligand-Biased Agonists of S1P1: Exploring Side Chain Modifications to Modulate the PK, PD, and Safety Profiles.
J Med Chem
; 64(3): 1454-1480, 2021 02 11.
Artigo
Inglês
| MEDLINE | ID: mdl-33492963
5.
Comparison of TNFα to lipopolysaccharide as an inflammagen to characterize the idiosyncratic hepatotoxicity potential of drugs: Trovafloxacin as an example.
Int J Mol Sci
; 11(11): 4697-714, 2010 Nov 18.
Artigo
Inglês
| MEDLINE | ID: mdl-21151465
6.
Aryl Ether-Derived Sphingosine-1-Phosphate Receptor (S1P1) Modulators: Optimization of the PK, PD, and Safety Profiles.
ACS Med Chem Lett
; 11(9): 1766-1772, 2020 Sep 10.
Artigo
Inglês
| MEDLINE | ID: mdl-32944145
7.
Identification and Preclinical Pharmacology of ((1 R,3 S)-1-Amino-3-(( S)-6-(2-methoxyphenethyl)-5,6,7,8-tetrahydronaphthalen-2-yl)cyclopentyl)methanol (BMS-986166): A Differentiated Sphingosine-1-phosphate Receptor 1 (S1P1) Modulator Advanced into Clinical Trials.
J Med Chem
; 62(5): 2265-2285, 2019 03 14.
Artigo
Inglês
| MEDLINE | ID: mdl-30785748
8.
p38 mitogen-activated protein kinase-dependent tumor necrosis factor-alpha-converting enzyme is important for liver injury in hepatotoxic interaction between lipopolysaccharide and ranitidine.
J Pharmacol Exp Ther
; 326(1): 144-52, 2008 Jul.
Artigo
Inglês
| MEDLINE | ID: mdl-18390808
9.
Metabolomic profiling distinction of human nonalcoholic fatty liver disease progression from a common rat model.
Obesity (Silver Spring)
; 25(6): 1069-1076, 2017 06.
Artigo
Inglês
| MEDLINE | ID: mdl-28452429
10.
Identification of potent tricyclic prodrug S1P1 receptor modulators.
Medchemcomm
; 8(4): 725-729, 2017 Apr 01.
Artigo
Inglês
| MEDLINE | ID: mdl-30108791
11.
p53-independent induction of rat hepatic Mdm2 following administration of phenobarbital and pregnenolone 16alpha-carbonitrile.
Toxicol Sci
; 94(2): 272-80, 2006 Dec.
Artigo
Inglês
| MEDLINE | ID: mdl-17000718
12.
Unique gene expression and hepatocellular injury in the lipopolysaccharide-ranitidine drug idiosyncrasy rat model: comparison with famotidine.
Toxicol Sci
; 90(2): 569-85, 2006 Apr.
Artigo
Inglês
| MEDLINE | ID: mdl-16415329
13.
Identification and Preclinical Pharmacology of BMS-986104: A Differentiated S1P1 Receptor Modulator in Clinical Trials.
ACS Med Chem Lett
; 7(3): 283-8, 2016 Mar 10.
Artigo
Inglês
| MEDLINE | ID: mdl-26985316
14.
Asymmetric Hydroboration Approach to the Scalable Synthesis of ((1R,3S)-1-Amino-3-((R)-6-hexyl-5,6,7,8-tetrahydronaphthalen-2-yl)cyclopentyl)methanol (BMS-986104) as a Potent S1P1 Receptor Modulator.
J Med Chem
; 59(24): 11138-11147, 2016 12 22.
Artigo
Inglês
| MEDLINE | ID: mdl-28002964
15.
Increased hepatobiliary clearance of unconjugated thyroxine determines DMP 904-induced alterations in thyroid hormone homeostasis in rats.
Toxicol Sci
; 84(2): 232-42, 2005 Apr.
Artigo
Inglês
| MEDLINE | ID: mdl-15673846
16.
Metabolic detoxification determines species differences in coumarin-induced hepatotoxicity.
Toxicol Sci
; 80(2): 249-57, 2004 Aug.
Artigo
Inglês
| MEDLINE | ID: mdl-15141102
17.
Diethanolamine induces hepatic choline deficiency in mice.
Toxicol Sci
; 67(1): 38-45, 2002 May.
Artigo
Inglês
| MEDLINE | ID: mdl-11961214
18.
Incorporating mechanistic data into risk assessment.
Toxicology
; 181-182: 271-4, 2002 Dec 27.
Artigo
Inglês
| MEDLINE | ID: mdl-12505324
19.
Immunohistochemical analysis of Clara cell secretory protein expression in a transgenic model of mouse lung carcinogenesis.
Toxicology
; 187(2-3): 217-28, 2003 May 03.
Artigo
Inglês
| MEDLINE | ID: mdl-12699910
20.
Liquid chromatographic determination of the glutathione conjugate and ring-opened metabolites formed from coumarin epoxidation.
J Chromatogr B Analyt Technol Biomed Life Sci
; 794(2): 257-71, 2003 Sep 05.
Artigo
Inglês
| MEDLINE | ID: mdl-12954377