Detalhe da pesquisa
1.
High-throughput combinatorial screening identifies drugs that cooperate with ibrutinib to kill activated B-cell-like diffuse large B-cell lymphoma cells.
Proc Natl Acad Sci U S A
; 111(6): 2349-54, 2014 Feb 11.
Artigo
Inglês
| MEDLINE | ID: mdl-24469833
2.
Structure activity relationships of human galactokinase inhibitors.
Bioorg Med Chem Lett
; 25(3): 721-7, 2015 Feb 01.
Artigo
Inglês
| MEDLINE | ID: mdl-25553891
3.
Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis.
Nat Chem Biol
; 8(10): 839-47, 2012 Oct.
Artigo
Inglês
| MEDLINE | ID: mdl-22922757
4.
A high throughput glucocerebrosidase assay using the natural substrate glucosylceramide.
Anal Bioanal Chem
; 402(2): 731-9, 2012 Jan.
Artigo
Inglês
| MEDLINE | ID: mdl-22033823
5.
2-Oxo-N-aryl-1,2,3,4-tetrahydroquinoline-6-sulfonamides as activators of the tumor cell specific M2 isoform of pyruvate kinase.
Bioorg Med Chem Lett
; 21(21): 6322-7, 2011 Nov 01.
Artigo
Inglês
| MEDLINE | ID: mdl-21958545
6.
Evaluation of thieno[3,2-b]pyrrole[3,2-d]pyridazinones as activators of the tumor cell specific M2 isoform of pyruvate kinase.
Bioorg Med Chem Lett
; 20(11): 3387-93, 2010 Jun 01.
Artigo
Inglês
| MEDLINE | ID: mdl-20451379
7.
Monitoring compound integrity with cytochrome P450 assays and qHTS.
J Biomol Screen
; 14(5): 538-46, 2009 Jun.
Artigo
Inglês
| MEDLINE | ID: mdl-19483146
8.
Evaluation of substituted 6-arylquinazolin-4-amines as potent and selective inhibitors of cdc2-like kinases (Clk).
Bioorg Med Chem Lett
; 19(23): 6700-5, 2009 Dec 01.
Artigo
Inglês
| MEDLINE | ID: mdl-19837585
9.
Discovery of N-{[1-(propylsulfonyl)-4-pyridin-2-ylpiperidin-4-yl]methyl}benzamides as novel, selective and potent GlyT1 inhibitors.
Bioorg Med Chem Lett
; 19(5): 1488-91, 2009 Mar 01.
Artigo
Inglês
| MEDLINE | ID: mdl-19179073
10.
Discovery of GlyT1 inhibitors with improved pharmacokinetic properties.
Bioorg Med Chem Lett
; 19(5): 1492-5, 2009 Mar 01.
Artigo
Inglês
| MEDLINE | ID: mdl-19181525
11.
Synthesis of Oxadiazole-2-oxide Analogues as Potential Antischistosomal Agents.
Tetrahedron Lett
; 50(15): 1710-1713, 2009 Apr.
Artigo
Inglês
| MEDLINE | ID: mdl-19802367
12.
Facile High-Performance Liquid Chromatography Mass Spectrometry Method for Analysis of Cyclocreatine and Phosphocyclocreatine in Complex Mixtures of Amino Acids.
J Agric Food Chem
; 67(25): 7190-7196, 2019 Jun 26.
Artigo
Inglês
| MEDLINE | ID: mdl-31194545
13.
Identification of a potent new chemotype for the selective inhibition of PDE4.
Bioorg Med Chem Lett
; 18(4): 1297-303, 2008 Feb 15.
Artigo
Inglês
| MEDLINE | ID: mdl-18243697
14.
Design, synthesis, and tripeptidyl peptidase II inhibitory activity of a novel series of (S)-2,3-dihydro-2-(4-alkyl-1H-imidazol-2-yl)-1H-indoles.
J Med Chem
; 45(24): 5303-10, 2002 Nov 21.
Artigo
Inglês
| MEDLINE | ID: mdl-12431057
15.
Discovery of positive allosteric modulators for the metabotropic glutamate receptor subtype 5 from a series of N-(1,3-diphenyl-1H- pyrazol-5-yl)benzamides that potentiate receptor function in vivo.
J Med Chem
; 47(24): 5825-8, 2004 Nov 18.
Artigo
Inglês
| MEDLINE | ID: mdl-15537338
16.
Efficient synthesis of imidazoles from aldehydes and 1,2-diketones using microwave irradiation.
Org Lett
; 6(9): 1453-6, 2004 Apr 29.
Artigo
Inglês
| MEDLINE | ID: mdl-15101765
17.
4-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-N-(4-methoxypyridin-2-yl)piperazine-1-carbothioamide (ML267), a potent inhibitor of bacterial phosphopantetheinyl transferase that attenuates secondary metabolism and thwarts bacterial growth.
J Med Chem
; 57(3): 1063-78, 2014 Feb 13.
Artigo
Inglês
| MEDLINE | ID: mdl-24450337
18.
Discovery, structure-activity relationship, and biological evaluation of noninhibitory small molecule chaperones of glucocerebrosidase.
J Med Chem
; 55(12): 5734-48, 2012 Jun 28.
Artigo
Inglês
| MEDLINE | ID: mdl-22646221
19.
Evaluation of quinazoline analogues as glucocerebrosidase inhibitors with chaperone activity.
J Med Chem
; 54(4): 1033-58, 2011 Feb 24.
Artigo
Inglês
| MEDLINE | ID: mdl-21250698
20.
Separation of Betti Reaction Product Enantiomers: Absolute Configuration and Inhibition of Botulinum Neurotoxin A.
ACS Med Chem Lett
; 2(5): 396-401, 2011 Mar 10.
Artigo
Inglês
| MEDLINE | ID: mdl-22102940