Detalhe da pesquisa
1.
Population pharmacokinetics and pharmacodynamics of efmarodocokin alfa (IL-22Fc).
J Pharmacokinet Pharmacodyn
; 51(2): 141-153, 2024 Apr.
Artigo
Inglês
| MEDLINE | ID: mdl-37864000
2.
Dose escalation randomised study of efmarodocokin alfa in healthy volunteers and patients with ulcerative colitis.
Gut
; 72(8): 1451-1461, 2023 Aug.
Artigo
Inglês
| MEDLINE | ID: mdl-36732049
3.
Astegolimab or Efmarodocokin Alfa in Patients With Severe COVID-19 Pneumonia: A Randomized, Phase 2 Trial.
Crit Care Med
; 51(1): 103-116, 2023 01 01.
Artigo
Inglês
| MEDLINE | ID: mdl-36519984
4.
Basal cells contribute to innate immunity of the airway epithelium through production of the antimicrobial protein RNase 7.
J Immunol
; 194(7): 3340-50, 2015 Apr 01.
Artigo
Inglês
| MEDLINE | ID: mdl-25712218
5.
Comprehensive profiling of the human fecal proteome from IBD patients with DIA-MS enables evaluation of disease-relevant proteins.
Proteomics Clin Appl
; : e2300075, 2024 Mar 29.
Artigo
Inglês
| MEDLINE | ID: mdl-38552248
6.
Sialic Acid Mediated Endothelial and Hepatic Uptake: A Mechanism based Mathematic Model Elucidating the Complex Pharmacokinetics and Pharmacodynamics of Efmarodocokin Alfa, a Variably Glycosylated Fusion Protein.
J Pharm Sci
; 2024 Mar 30.
Artigo
Inglês
| MEDLINE | ID: mdl-38561054
7.
IL-22 alters gut microbiota composition and function to increase aryl hydrocarbon receptor activity in mice and humans.
Microbiome
; 11(1): 47, 2023 03 09.
Artigo
Inglês
| MEDLINE | ID: mdl-36894983
8.
A phase I, randomized, ascending-dose study to assess safety, pharmacokinetics, and activity of GDC-8264, a RIP1 inhibitor, in healthy volunteers.
Clin Transl Sci
; 16(10): 1997-2009, 2023 10.
Artigo
Inglês
| MEDLINE | ID: mdl-37596814
9.
SAkuraBONSAI: Protocol design of a novel, prospective study to explore clinical, imaging, and biomarker outcomes in patients with AQP4-IgG-seropositive neuromyelitis optica spectrum disorder receiving open-label satralizumab.
Front Neurol
; 14: 1114667, 2023.
Artigo
Inglês
| MEDLINE | ID: mdl-36873431
10.
The kinase IRAK4 promotes endosomal TLR and immune complex signaling in B cells and plasmacytoid dendritic cells.
Sci Signal
; 13(634)2020 06 02.
Artigo
Inglês
| MEDLINE | ID: mdl-32487715
11.
Randomized Phase I Healthy Volunteer Study of UTTR1147A (IL-22Fc): A Potential Therapy for Epithelial Injury.
Clin Pharmacol Ther
; 105(1): 177-189, 2019 01.
Artigo
Inglês
| MEDLINE | ID: mdl-29952004
12.
Pre-clinical and translational pharmacology of a human interleukin-22 IgG fusion protein for potential treatment of infectious or inflammatory diseases.
Biochem Pharmacol
; 152: 224-235, 2018 06.
Artigo
Inglês
| MEDLINE | ID: mdl-29608910
13.
Nonclinical safety assessment of a human interleukin-22FC IG fusion protein demonstrates in vitro to in vivo and cross-species translatability.
Pharmacol Res Perspect
; 6(6): e00434, 2018 12.
Artigo
Inglês
| MEDLINE | ID: mdl-30464842
14.
Pathogens use carbohydrates to escape immunity induced by dendritic cells.
Curr Opin Immunol
; 16(4): 488-93, 2004 Aug.
Artigo
Inglês
| MEDLINE | ID: mdl-15245744
15.
Antibacterial Defense of Human Airway Epithelial Cells from Chronic Obstructive Pulmonary Disease Patients Induced by Acute Exposure to Nontypeable Haemophilus influenzae: Modulation by Cigarette Smoke.
J Innate Immun
; 9(4): 359-374, 2017.
Artigo
Inglês
| MEDLINE | ID: mdl-28171878
16.
Viral piracy: HIV-1 targets dendritic cells for transmission.
Curr HIV Res
; 4(2): 169-76, 2006 Apr.
Artigo
Inglês
| MEDLINE | ID: mdl-16611055
17.
SYK is a candidate kinase target for the treatment of advanced prostate cancer.
Cancer Res
; 75(1): 230-40, 2015 Jan 01.
Artigo
Inglês
| MEDLINE | ID: mdl-25388286
18.
Cellular players in lung fibrosis.
Curr Pharm Des
; 18(27): 4093-102, 2012.
Artigo
Inglês
| MEDLINE | ID: mdl-22630084
19.
Mucosal-targeted AIDS vaccines: the next generation?
Trends Microbiol
; 12(10): 447-50, 2004 Oct.
Artigo
Inglês
| MEDLINE | ID: mdl-15381193
20.
Potency of HIV-1 envelope glycoprotein gp120 antibodies to inhibit the interaction of DC-SIGN with HIV-1 gp120.
Virology
; 329(2): 465-76, 2004 Nov 24.
Artigo
Inglês
| MEDLINE | ID: mdl-15518824