Breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) in Poland: analysis of patient series and practical guidelines for breast surgeons.

Introduction: Although breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) is infrequent, with less than 1000 noted cases worldwide, patients consenting for breast implant surgery should be aware of its risk. We describe the first Polish multicenter case-series data on BIA-ALCL patients and present diagnostic and treatment recommendation for breast surgeons. Material and methods: In cooperation with the Polish Society of Surgical Oncology and Polish Lymphoma Research Group, we collected BIA-ALCL cases in Poland. Results: We retrospectively reviewed clinical data of seven BIA-ALCL patients, diagnosed between July 2013 and November 2019. The median time from implant placement to the first BIA-ALCL symptoms was 65 months (range: 33-96 months). All the patients were exposed to textured implants at presentation. Capsulectomy with implant removal was performed in all the patients with immediate reimplantation in 2 cases. In a median follow-up of 19 months (range 5-81 months), there was no recurrence and all the patients stayed alive. Between 2013 and 2019, the incidence of BIA-ALCL in Polish female population age 30 and above ranged from 0 to 0.021/100 000/year. Conclusions: BIA-ALCL is scarce in the Polish population. In a short-term follow-up, patients' prognosis remains excellent. Due to the withdrawal of roughly textured implants from the market and the exclusion of likely the most potent etiologic factor, it might be expected that the incidence of BIA-ALCL will become even rarer.

Reconstruction in case of full thickness abdominal wall defects due to necrotizing fascitis - case report.

Emergency full thickness abdominal wall defects constitute a challenging problem for surgeons. The aim of reconstruction is prevention of evisceration and hernia formation. Staged surgery is recommended in such cases. The first stage consists of wound healing with skin grafts and creation of "planned hernia". Ultimate reconstruction is delayed until good general health state of the patient. In presented case final skin and subcutaneous tissue reconstruction was achieved with island fasciocutaneous antero-lateral thigh flap. Reconstruction of musculo-aponeurotic layer was completed with compartment separation technique and synthetic mesh. During follow-up no recurrence of deformity was observed.

[Clinical and therapeutical implications of molecular aspects of Dupuytren's disease pathogenesis]. / Znaczenie kliniczne i terapeutyczne molekularnych aspektów patogenezy choroby Dupuytrena.

Etiology and pathogenesis of Dupuytren's disease still remains unclear. This disease like other conditions resulting from chronic pathological fibrosis (organ fibromatoses, intraperitoneal adhesions, hypertrophic scars) remains a therapeutic problem. These facts substantiate fully research on processes leading to pathological changes in these diseases. The ongoing research is not only to broaden our knowledge but mainly to work out methods of causal treatment. Despite significant observations in vitro and in clinical trials, practical applications from these studies are still a way ahead. Consequently, symptomatic surgical treatment of Dupuytren's disease still remains the method of choice.