Detalhe da pesquisa
1.
Genetic variants of phospholipase C-γ2 alter the phenotype and function of microglia and confer differential risk for Alzheimer's disease.
Immunity
; 56(9): 2121-2136.e6, 2023 09 12.
Artigo
Inglês
| MEDLINE | ID: mdl-37659412
2.
Discovery of SARS-CoV-2 antiviral drugs through large-scale compound repurposing.
Nature
; 586(7827): 113-119, 2020 10.
Artigo
Inglês
| MEDLINE | ID: mdl-32707573
3.
Chloropyridinyl Esters of Nonsteroidal Anti-Inflammatory Agents and Related Derivatives as Potent SARS-CoV-2 3CL Protease Inhibitors.
Molecules
; 26(19)2021 Sep 24.
Artigo
Inglês
| MEDLINE | ID: mdl-34641337
4.
Design, synthesis, X-ray studies, and biological evaluation of novel BACE1 inhibitors with bicyclic isoxazoline carboxamides as the P3 ligand.
Bioorg Med Chem Lett
; 28(15): 2605-2610, 2018 08 15.
Artigo
Inglês
| MEDLINE | ID: mdl-29970308
5.
Exploration of P1 and P4 modifications of nirmatrelvir: Design, synthesis, biological evaluation, and X-ray structural studies of SARS-CoV-2 Mpro inhibitors.
Eur J Med Chem
; 267: 116132, 2024 Mar 05.
Artigo
Inglês
| MEDLINE | ID: mdl-38335815
6.
Indole Chloropyridinyl Ester-Derived SARS-CoV-2 3CLpro Inhibitors: Enzyme Inhibition, Antiviral Efficacy, Structure-Activity Relationship, and X-ray Structural Studies.
J Med Chem
; 64(19): 14702-14714, 2021 10 14.
Artigo
Inglês
| MEDLINE | ID: mdl-34528437
7.
A small molecule compound with an indole moiety inhibits the main protease of SARS-CoV-2 and blocks virus replication.
Nat Commun
; 12(1): 668, 2021 01 28.
Artigo
Inglês
| MEDLINE | ID: mdl-33510133
8.
Preclinical characterization of an intravenous coronavirus 3CL protease inhibitor for the potential treatment of COVID19.
Nat Commun
; 12(1): 6055, 2021 10 18.
Artigo
Inglês
| MEDLINE | ID: mdl-34663813
9.
Discovery of a Novel Inhibitor of Coronavirus 3CL Protease for the Potential Treatment of COVID-19.
bioRxiv
; 2021 Feb 12.
Artigo
Inglês
| MEDLINE | ID: mdl-32935104
10.
Highly Selective and Potent Human ß-Secretaseâ 2 (BACE2) Inhibitors against Typeâ 2 Diabetes: Design, Synthesis, X-ray Structure and Structure-Activity Relationship Studies.
ChemMedChem
; 14(5): 545-560, 2019 03 05.
Artigo
Inglês
| MEDLINE | ID: mdl-30637955