RESUMO
Variations of the indices of endogenous intoxication, lipid peroxidation, oxidative modification of proteins, and antioxidant system operation have been studied in animals with acute experimental cholecystitis. The possibility and effectiveness of using succinate-containing drugs reamberin and mexidol for the correction of these impairments has been assessed. In the present study, reamberin effectively reduced the intensity of lipid peroxidation and protein modification in experimental animals.
Assuntos
Antioxidantes/farmacologia , Colecistite Aguda/sangue , Colecistite Aguda/tratamento farmacológico , Meglumina/análogos & derivados , Picolinas/farmacologia , Succinatos/farmacologia , Animais , Proteínas Sanguíneas/metabolismo , Catalase/sangue , Colecistite Aguda/fisiopatologia , Modelos Animais de Doenças , Feminino , Cobaias , Injeções Intramusculares , Injeções Intraperitoneais , Peroxidação de Lipídeos/efeitos dos fármacos , Masculino , Malondialdeído/sangue , Meglumina/farmacologia , Oxirredução/efeitos dos fármacos , Estresse Oxidativo/efeitos dos fármacos , Superóxido Dismutase/sangueRESUMO
The authors investigated peculiarities of occlusive and stenotic arterial lesions influencing the pattern of revascularization in patients presenting with a neuroischaemic form of diabetic foot syndrome. We examined a total of 106 patients with a neuroischaemic form of diabetic foot syndrome and undergoing treatment at the City Municipal Centre for Diabetic Foot in the City of Minsk. In order to visualize the arteries in 82 (77.4%) cases we used contrast-enhanced angiography, in 16 (15.1%) cases - CT angiography, and in 8 (7.5%) cases a combination of the both methods was used. The overwhelming majority of patients were found to have distal occlusion with lesions of three and two crural arteries. Standard approaches made it possible to perform revascularization only in 46 (43.9%) patients in the examined group. A promising trend of improving rendering care for patients with a neuroischaemic form of diabetic foot syndrome and decreasing the rate of high amputations consists in thrther development and implementation of hybrid technologies of limb revascularization, as well as adequate material and technical provision of such interventions.