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1.
J Natl Cancer Inst ; 59(4): 1065-71, 1977 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-333121

RESUMO

This report presents an analysis of several demographic discriminants of stomach cancer incidence for residents of the Pittsburgh Standard Metropolitan Statistical Area (SMSA) with the use of data collected as part of the Third National Cancer Survey, 1969-71. The Pittsburgh SMSA, one of nine areas included in the Third National Cancer Survey, was of particular interest in the study of stomach cancer, since area residents showed the highest age-adjusted incidence rate for cancer of this site while showing the fifth highest rate for all sites. To examine the data in greater detail, we used the variables of sex, race, nativity, and median income level to classify the cancer patients into homogeneous subgroups of census tracts of residence to allow comparisons of the average annual age-adjusted incidence rates among the groups. The data indicated that Pittsburgh SMSA residents showed stomach cancer incidence patterns that were generally consistent with earlier published reports; particularly when contrasted with appropriate population subgroups, higher rates appeared for males, for blacks, for lower income areas, and for areas with "large" proportions of foreign-born and foreign-stock residents. Furthermore, when one considered interactions among the factors, the relationship between ethnic composition and incidence appeared to supercede that of income among white males.


Assuntos
População Negra , Etnicidade , Neoplasias Gástricas/epidemiologia , População Branca , Adulto , Idoso , Métodos Epidemiológicos , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Pennsylvania , Fatores Sexuais , Fatores Socioeconômicos , População Urbana
2.
J Perinatol ; 36(9): 758-62, 2016 09.
Artigo em Inglês | MEDLINE | ID: mdl-27228507

RESUMO

OBJECTIVE: Evaluate the impact of a non-neonatal intensive care unit (NICU)-specific peer counseling (PC) program on the cessation of human milk receipt at and post-NICU discharge. STUDY DESIGN: A multivariable logistic regression model used data from 400 mother-infant dyads from a level IV NICU to compare cessation of human milk receipt at NICU discharge by PC program status. Kaplan-Meier distributions and a multivariable Cox proportional hazards model assessed the relationship between participants/non-participants and cessation of human milk post-NICU discharge. RESULTS: No statistically significant differences between groups in cessation of human milk either by or post-discharge were observed. Identified variables associated with the outcome(s) of interest included maternal and infant age, length of stay, presence of a breastfeeding duration goal and frequency of NICU lactation consultant contact. CONCLUSION: Exposure to a non NICU-specific PC program was not associated with human milk receipt either by or post-NICU discharge.


Assuntos
Aconselhamento/métodos , Leite Humano , Mães , Grupo Associado , Connecticut , Feminino , Humanos , Lactente , Recém-Nascido , Unidades de Terapia Intensiva Neonatal , Estimativa de Kaplan-Meier , Modelos Logísticos , Masculino , Análise Multivariada , Alta do Paciente , Avaliação de Programas e Projetos de Saúde
3.
Am J Med ; 91(3B): 158S-163S, 1991 Sep 16.
Artigo em Inglês | MEDLINE | ID: mdl-1928157

RESUMO

During a 4-year period, we collected prospective epidemiologic data and intraoperative wound cultures from 1,852 surgery patients at a university-affiliated community hospital in order to identify the critical risk factors for postoperative wound infections and study the impact of perioperative antibiotics on the bacteriology of infected wounds. Stepwise logistic regression analysis revealed four risk factors that were independent of each other and highly predictive for subsequent wound infection. These were the surgical wound class, American Society of Anesthesiologists physical status grouping, duration of surgery, and results of intraoperative cultures. Addition of other variables to our model did not increase the predicted probability of infection. Even though patients with positive intraoperative cultures had an increased rate of infection, this information had limited clinical utility. The predictive value of a positive culture was low (32%), false-positive rate was high (82%), and concordance with isolates from infected wounds was low (41% when both cultures were positive). Patients who had received perioperative antibiotics and who developed infections were frequently infected with organisms that were resistant to the perioperative drug regimen, compared with patients who had not received antibiotics. A better understanding of the variables that affect the epidemiology and pathogenesis of postoperative wound infection will enable us to make more valid comparisons of rates among hospitals, help us to develop more effective infection control strategies and provide us with more effective treatments.


Assuntos
Infecções , Complicações Pós-Operatórias , Adulto , Idoso , Bactérias/isolamento & purificação , Resistência Microbiana a Medicamentos , Feminino , Humanos , Infecções/epidemiologia , Infecções/microbiologia , Masculino , Pessoa de Meia-Idade , Complicações Pós-Operatórias/epidemiologia , Complicações Pós-Operatórias/microbiologia , Fatores de Risco , Índice de Gravidade de Doença , Procedimentos Cirúrgicos Operatórios
4.
Pediatrics ; 96(2 Pt 1): 278-82, 1995 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-7630684

RESUMO

BACKGROUND: Firearm injuries are a major cause of pediatric mortality and morbidity in the United States. To date, population-based studies describe the epidemiology of firearm-related deaths; however, the patterns of severe, nonfatal pediatric firearm-related injuries are not as well defined. OBJECTIVES: To determine the epidemiology of severe firearm-related deaths and injuries among a statewide population of children and youth ages birth to 19 years. METHODS: Demographic, geographic, and cost data were analyzed from Connecticut death certificates for 1988 through 1992 and hospital discharge data for 1986 through 1990 for firearm-related unintentional, self-inflicted, and assaultive injury among children and youth ages birth to 19 years. RESULTS: There were 219 firearm deaths: 68% homicides, 25% suicides, 6% unintentional, and 1% of undetermined intent, resulting in an annual age-specific death rate of 6.6 per 100,000 persons. There were 533 hospitalizations for gunshot wounds (16 per 100,000); 41% were assaults, 1% suicide attempts, 39% unintentional gunshot wounds, 1% legal interventions, and 18% of undetermined intent. More than 80% of deaths from gunshot wounds and hospitalizations occurred among 15- to 19-year-old males, most occurring in Connecticut's five largest cities. Most firearm homicides occurred among urban residents; most firearm suicides occurred among nonurban residents; and unintentional shootings were evenly distributed between urban and nonurban residents. The total cost of firearm-related hospitalizations averaged $864,000 per year. CONCLUSIONS: Firearms are a major cause of mortality and morbidity of Connecticut children and youth, exceeded only by motor vehicles as a cause of death among those 1 to 19 years of age. Handguns were responsible for a disproportionate amount of trauma compared with other firearm types. The epidemiology of pediatric gunshot injuries requires a range of strategies for prevention. Physicians caring for families with children must include firearm injury prevention counseling as a routine part of anticipatory guidance.


Assuntos
Ferimentos por Arma de Fogo/epidemiologia , Acidentes/estatística & dados numéricos , Adolescente , Adulto , Fatores Etários , Criança , Pré-Escolar , Connecticut/epidemiologia , Custos e Análise de Custo , Atestado de Óbito , Feminino , Homicídio/estatística & dados numéricos , Hospitalização/economia , Hospitalização/estatística & dados numéricos , Humanos , Lactente , Recém-Nascido , Masculino , Alta do Paciente/estatística & dados numéricos , Vigilância da População , Comportamento Autodestrutivo/economia , Comportamento Autodestrutivo/epidemiologia , Fatores Sexuais , Suicídio/estatística & dados numéricos , Saúde da População Urbana/estatística & dados numéricos , Violência/estatística & dados numéricos , Ferimentos por Arma de Fogo/economia , Ferimentos por Arma de Fogo/mortalidade
5.
Pediatrics ; 71(3): 364-72, 1983 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-6338474

RESUMO

As a first step in a multicenter, collaborative project to study the role of indomethacin in the management of patent ductus arteriosus in premature infants, a diagnostic scheme was developed, on an a priori basis, by a consensus of the participating neonatologists and pediatric cardiologists. The scheme, which utilizes clinical and noninvasive findings, was designed to detect infants with a "hemodynamically significant" patent ductus arteriosus (PDA). Among 1,689 infants with birth weight less than 1,750 g who were monitored during the first year of the study, 342 (20.2%) met the criteria for PDA. Rates were higher for smaller infants (42% with birth weight less than 1,000 g) than for larger infants (7% with birth weight 1,500 to 1,750 g). Although study protocol did not require a direct procedure to confirm the diagnosis of PDA, a marked decrease in the presence of most criteria was noted following surgical ligation of the ductus. Although the echocardiographic criterion (ratio of left atrium to aorta [LA/Ao] greater than or equal to 1.15) proved to have a low specificity for PDA, the data suggest that the overall scheme led to a very low rate of false-positive diagnosis. Following the application of the scheme for 1 year at 13 clinical centers, it has been shown to be a highly acceptable means of detecting infants with PDA.


Assuntos
Permeabilidade do Canal Arterial/diagnóstico , Recém-Nascido Prematuro , Ensaios Clínicos como Assunto , Permeabilidade do Canal Arterial/terapia , Ecocardiografia , Sopros Cardíacos , Humanos , Recém-Nascido , Monitorização Fisiológica
6.
Pediatrics ; 104(4 Pt 1): 911-7, 1999 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-10506234

RESUMO

OBJECTIVE: To investigate the relative efficacy of orally administered cefadroxil and penicillin V in the treatment of group A streptococcal (GABHS) pharyngitis and the mechanism(s) responsible for failure of antimicrobial therapy to eradicate GABHS from the pharynx. STUDY DESIGN: A prospective, randomized clinical trial was conducted in four pediatric offices in which 462 patients with acute pharyngitis and positive culture for GABHS were randomly assigned to receive cefadroxil (n = 232) or penicillin V (n = 230). RESULTS: Bacteriologic treatment success rates for patients in cefadroxil and penicillin groups were 94% and 86%, respectively. However, among patients classified clinically as likely to have bona fide GABHS pharyngitis, there was no difference in bacteriologic treatment success rates in cefadroxil and penicillin groups (95% and 94%, respectively). Among patients classified clinically as likely to be streptococcal carriers, bacteriologic treatment success rates in cefadroxil and penicillin groups were 92% and 73%, respectively. The presence of beta-lactamase and/or bacteriocin-producing pharyngeal flora had no consistent effect on bacteriologic eradication rates among patients in either penicillin or cefadroxil treatment groups or among patients classified as having either GABHS pharyngitis or streptococcal carriage. CONCLUSIONS: Neither beta-lactamase nor bacteriocin produced by normal pharyngeal flora are related to bacteriologic treatment failures in GABHS pharyngitis. Cefadroxil seems to be more effective than penicillin V in eradicating GABHS from patients classified as more likely to be streptococcal carriers. However, among patients we classified as more likely to have bona fide GABHS pharyngitis, the effectiveness of cefadroxil and penicillin V seems to be comparable.


Assuntos
Cefadroxila/uso terapêutico , Cefalosporinas/uso terapêutico , Penicilina V/uso terapêutico , Penicilinas/uso terapêutico , Faringite/microbiologia , Infecções Estreptocócicas/tratamento farmacológico , Streptococcus pyogenes/metabolismo , Doença Aguda , Adolescente , Análise de Variância , Antibiose , Portador Sadio/tratamento farmacológico , Portador Sadio/microbiologia , Criança , Pré-Escolar , Humanos , Faringite/tratamento farmacológico , Estudos Prospectivos , Método Simples-Cego , Infecções Estreptocócicas/microbiologia , Falha de Tratamento , beta-Lactamases/metabolismo
7.
Infect Control Hosp Epidemiol ; 9(3): 109-13, 1988 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-3351267

RESUMO

The efficacy of total body showering and incision site scrub with disinfectant agents was evaluated in a randomized, prospective study of 575 patients undergoing selected surgical procedures. Patients who showered twice with 4% chlorhexidine gluconate had lower mean colony counts of skin bacteria at the surgical incision site in the operating room prior to the final scrub than patients who showered twice with povidone-iodine solution or medicated bar soap. Patients in the chlorhexidine group had no growth on 43% of the incision site skin cultures compared with 16% in the povidone-iodine group and 6% in the soap and water group. Patients who showered and who were scrubbed with chlorhexidine also had lower rates of intraoperative wound contamination. Bacteria were recovered from the wounds of 4% of patients using this regimen compared with 9% for patients who used povidone-iodine and 15% for patients who showered with medicated soap and water and were scrubbed with povidone-iodine. We noted no difference in surgery-specific infection rates among patients in the three treatment groups; however, our sample sizes were too small to evaluate this outcome parameter adequately. These data suggest that preoperative showering and scrubbing with chlorhexidine is an effective regimen to reduce extrinsic intraoperative contamination of the surgical wound from skin bacteria. The efficacy of this regimen to prevent postoperative wound infection needs to be evaluated in a well-designed, carefully controlled prospective trial with adequate numbers of patients to achieve statistically valid conclusions.


Assuntos
Banhos , Clorexidina/uso terapêutico , Desinfecção/métodos , Povidona-Iodo/uso terapêutico , Povidona/análogos & derivados , Pele/microbiologia , Esterilização/métodos , Infecção da Ferida Cirúrgica/prevenção & controle , Feminino , Humanos , Masculino , Cuidados Pré-Operatórios , Estudos Prospectivos , Sabões
8.
Obstet Gynecol ; 94(1): 120-3, 1999 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-10389731

RESUMO

OBJECTIVE: Evaluate neonatal morbidity in deliveries occurring between 34 0/7 and 36 6/7 weeks' gestation, comparing outcomes in pregnancies complicated by preterm premature rupture of membranes with those in which delivery occurred with intact membranes prior to the onset of labor. METHODS: The obstetric database was reviewed for a 5-year period. Healthy gravidas delivering nonanomalous singleton gestations from vertex presentations were evaluated, with corticosteroid or antibiotic administration or both noted. The neonatal database was reviewed for the following complications: admission to the neonatal intensive care unit, need for assisted ventilation, and development of hyaline membrane disease, bronchopulmonary dysplasia, intraventricular hemorrhage, necrotizing enterocolitis, or culture-proven sepsis. Groups were compared using chi2 tests. The power of this study to detect a ten-fold decrease in the likelihood of neonatal complications at the P<.05 significance level was greater than 90%. RESULTS: Of 853 eligible pregnancies, 414 (48.5%) gravidas had ruptured membranes prior to the onset of active labor. No difference existed between groups in the number of patients who had received corticosteroids during pregnancy, but patients with ruptured membranes were more likely to have received antibiotics prior to delivery. No neonatal deaths occurred, and neonatal morbidity was low in both groups. CONCLUSION: No clinically significant difference exists in neonatal outcome between 34 0/7 and 36 6/7 weeks' gestation as the result of membrane status prior to the onset of labor.


Assuntos
Ruptura Prematura de Membranas Fetais , Doenças do Prematuro/etiologia , Doenças do Prematuro/mortalidade , Adulto , Feminino , Humanos , Recém-Nascido , Gravidez
9.
Diagn Microbiol Infect Dis ; 14(3): 195-201, 1991.
Artigo em Inglês | MEDLINE | ID: mdl-1716190

RESUMO

The accuracy of examination of the Gram-stained direct smear to classify presumptively Gram-negative rods into three morphotype groups, that is, (a) Enteric bacteria, (b) Pseudomonas, and (c) Bacteroides or Haemophilus, was evaluated. Randomly selected clinical strains (4-9) each of Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, Ps. aeruginosa, B. fragilis, and H. influenzae were used to produce peritonitis or subcutaneous abscesses in mice. A Gram-stained direct smear was prepared from exudate collected from each animal. The direct smears were examined to classify bacteria observed into one of the three morphotype groups. The percent accuracy was 82, 56, and 95, respectively, and 76 overall. The assumption was made that classification was based primarily on differences in length and width of the organisms. To test this hypothesis, we prepared scanning electron photomicrographs from each specimen of exudate and measured the lengths and widths of bacteria. Examination of the Gram-stained direct smear was more accurate for classification of enteric bacteria, H. influenzae, or B. fragilis. Electron microscopy was more accurate for classification of Ps. aeruginosa. The higher length-width radio should be helpful in recognizing Ps. aeruginosa in direct smears.


Assuntos
Bacteroides/isolamento & purificação , Enterobacteriaceae/isolamento & purificação , Haemophilus/isolamento & purificação , Pseudomonas aeruginosa/isolamento & purificação , Abscesso/microbiologia , Animais , Bacteroides/ultraestrutura , Análise Discriminante , Enterobacteriaceae/ultraestrutura , Escherichia coli/isolamento & purificação , Escherichia coli/ultraestrutura , Violeta Genciana , Haemophilus/ultraestrutura , Klebsiella pneumoniae/isolamento & purificação , Klebsiella pneumoniae/ultraestrutura , Camundongos , Microscopia Eletrônica de Varredura , Peritonite/microbiologia , Fenazinas , Proteus mirabilis/isolamento & purificação , Proteus mirabilis/ultraestrutura , Pseudomonas aeruginosa/ultraestrutura , Coloração e Rotulagem
10.
Diagn Microbiol Infect Dis ; 14(2): 157-66, 1991.
Artigo em Inglês | MEDLINE | ID: mdl-1873974

RESUMO

Innovative approaches are needed to improve cost-effective antibiotic use in hospitals. We established an algorithm to provide a recommendation for both a single oral and a single parenteral antimicrobic, including dosage, to be placed in the bacteriology laboratory report for therapy guidance of 174 episodes of lower respiratory infection in a group of "program" patients with no evidence of infection at other sites. The initial recommendation was based on the Gram-stained direct smear of secretions. The recommendation was updated when preliminary culture results were available, and again with final identification and susceptibility data. We compared the severity of illness, length of stay, and cost of therapy for 68 episodes in program patients who received the recommended therapy with 111 episodes in a control group of patients who received antimicrobial therapy but for whom no recommendations were reported. There was a significantly greater use of the recommendations for sicker patients. Antimicrobial therapy, in general, was more often used for the program patients than for the controls. There was no difference in length of stay or therapy cost. We recommend that this approach be used in settings where there is more problematic use of antimicrobics.


Assuntos
Algoritmos , Anti-Infecciosos/uso terapêutico , Laboratórios Hospitalares/métodos , Infecções Respiratórias/tratamento farmacológico , Escarro/microbiologia , Análise de Variância , Humanos
11.
J Hosp Infect ; 18 Suppl A: 289-98, 1991 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-1679795

RESUMO

During a 4-year period, we collected prospective epidemiological data and intraoperative wound cultures from 1852 surgery patients at a university-affiliated community hospital in order to identify the critical risk factors for postoperative wound infections and study the impact of perioperative antibiotics on the bacteriology of infected wounds. Stepwise logistic regression analysis revealed four risk factors that were independent of each other and highly predictive for subsequent wound infection. These were the surgical wound class, American Society of Anesthesiology (ASA) physical status grouping, duration of surgery and results of intraoperative cultures. Addition of other variables to our model did not increase the predicted probability of infection. Even though patients with positive intraoperative cultures had an increased rate of infection, this information had limited clinical utility because of its low predictive value, high false-positive rate and poor concordance with isolates from infected wounds. Patients who had received perioperative antibiotics and who developed infections were frequently infected with organisms that were resistant to the perioperative drug regimen, compared with patients who had not received antibiotics.


Assuntos
Complicações Intraoperatórias/epidemiologia , Infecção da Ferida Cirúrgica/epidemiologia , Anestesiologia , Feminino , Nível de Saúde , Hospitais Comunitários , Hospitais Universitários , Humanos , Complicações Intraoperatórias/classificação , Complicações Intraoperatórias/microbiologia , Modelos Logísticos , Masculino , Valor Preditivo dos Testes , Estudos Prospectivos , Fatores de Risco , Infecção da Ferida Cirúrgica/classificação , Infecção da Ferida Cirúrgica/microbiologia , Fatores de Tempo
12.
Am J Surg ; 152(5): 505-9, 1986 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-3535551

RESUMO

In a prospective, controlled clinical trial, nonwoven, disposable gown and drape fabrics were no better barriers to intraoperative wound contamination or postoperative wound infection than reusable cotton poplin. We observed no difference between the two study groups in either the frequency or level of intraoperative wound contamination as judged by cultures of specimens collected at the time of wound closure. Of procedures in which reusable fabrics were used, 13.1 percent had positive cultures compared with 15.5 percent of those in which disposable fabrics were used (difference not statistically significant). We recovered coagulase-negative Staphylococci from more than 95 percent of contaminated wounds. Rates of postoperative wound infection were virtually identical in the two groups. Our data suggest that either both fabrics were similar in their ability to block bacteria that were shed from skin surfaces from entering the wound, or that bacteria which contaminate the wound in clean surgical procedures are derived from sources other than skin.


Assuntos
Vestuário , Complicações Pós-Operatórias/prevenção & controle , Infecção da Ferida Cirúrgica/prevenção & controle , Ensaios Clínicos como Assunto , Método Duplo-Cego , Feminino , Humanos , Período Intraoperatório , Tempo de Internação , Masculino , Pessoa de Meia-Idade , Distribuição Aleatória
13.
Acad Emerg Med ; 8(12): 1147-52, 2001 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-11733292

RESUMO

UNLABELLED: Critics of the use of clinical practice guidelines (CPGs) in an emergency department (ED) setting believe that they are too cumbersome and time-consuming, but to the best of the authors' knowledge, potential barriers to CPG adherence in the ED have not been prospectively evaluated. OBJECTIVES: To measure provider adherence to an ED CPG based on National Asthma Education and Prevention Program (NAEPP) recommendations, and to determine factors associated with provider nonadherence. METHODS: Prospective, cohort study of children aged 1-18 years with the diagnosis of an acute exacerbation of asthma who were seen in a pediatric ED and requiring admission, as well as a random selection of children discharged to home following pediatric ED care. The following adherence parameters were assessed: at least three nebulized albuterol treatments in the first hour; early steroid administration (after the first nebulizer treatment); clinical assessments using pulse oximetry and peak expiratory flow (PEF) (for children >6 years old); and use of a clinical score to assess acute illness severity (Asthma Severity Score). Nonadherence was defined as any deviation of the above parameters. RESULTS: Between July 1, 1998, and June 30, 1999, 369 patients were studied. Of these, 38% (139) were discharged to home, 38% (140) were admitted to the observation unit, and 24% (90) were admitted to the inpatient unit. Illness severities at initial presentation to the ED were: 24% (86) had mild exacerbations, 59% (212) had moderate exacerbations, and 17% (62) had severe exacerbations. Sixty-eight percent (95% CI = 63% to 73%) of the patients were managed with complete adherence to the CPG. Of the 32% with some form of nonadherence, most (63%) were children older than 6 years; in this group 64% (48/75) were nonadherent due to lack of PEF assessment. When PEF assessment was disregarded, an 83% (95% CI = 79% to 87%) adherence to the CPG was achieved. Other nonadherence factors included: lack of at least three nebulized albuterol treatments provided timely within the first hour (5%); delay in steroid administration (6%); lack of pulse oximeter use (0.5%); and failure to record clinical score to assess severity (1.1%). Patient age, illness severity (acute and chronic), first episode of wheezing, and high ED volume periods (evenings and weekends) did not worsen adherence. CONCLUSIONS: Clinical practice guidelines can be used successfully in the pediatric ED and provide a more efficient management and treatment approach to acute exacerbations of childhood asthma. With a systematic and concise CPG, barriers to adherence in a pediatric ED appear to be minimal, with the exception of using PEF in the routine ED assessment.


Assuntos
Asma/diagnóstico , Asma/terapia , Serviço Hospitalar de Emergência/normas , Tratamento de Emergência/normas , Fidelidade a Diretrizes/estatística & dados numéricos , Guias de Prática Clínica como Assunto , Adolescente , Criança , Pré-Escolar , Estudos de Coortes , Intervalos de Confiança , Feminino , Humanos , Unidades de Terapia Intensiva Pediátrica , Masculino , Estudos Prospectivos , Índice de Gravidade de Doença , Estados Unidos
14.
Pediatr Neurol ; 7(5): 342-6, 1991.
Artigo em Inglês | MEDLINE | ID: mdl-1764135

RESUMO

One hundred nineteen questionnaires in which board certified/eligible child neurologists were asked to rank the diagnostic importance of 8 sources of information commonly used in the assessment of children with learning disabilities were analyzed by the Wilcoxon matched-pairs signed ranks test. All pairwise comparisons of the 8 sources revealed significant differences (P less than or equal to .033) except for psychologic reports (mean rank +/- 1 S.D. = 2.09 +/- 1.14) and medical histories (2.26 +/- 1.45) which were rated equal (P = .397) and, compared to the other sources, diagnostically most useful (P less than .0001). Analysis of the 6 remaining sources demonstrated the following: teachers' reports (3.39 +/- 1.35) were deemed more helpful than the mental status examination (3.92 +/- 1.61; P = .033) and questionnaires distributed to parents and teachers (5.05 +/- 2.11) were more useful than findings on the remainder of the neurologic examination (5.81 +/- 1.46; P = .012). Social service reports (6.45 +/- 1.32) took precedence over soft signs (7.12 +/- 1.05; P = .001) which were considered the least diagnostically helpful. Analysis of variance revealed that this rank order was relatively independent of the responders' age, type of practice, years elapsed since completion of training and percentage of professional time spent examining pediatric patients. Information derived from outside sources (collective mean rank +/- 1 S.D. = 4.25 +/- 0.9) contributed significantly more to the diagnosis of learning disabilities than to information elicited directly by the examining neurologists (4.77 +/- .88; P = .002).(ABSTRACT TRUNCATED AT 250 WORDS)


Assuntos
Deficiências da Aprendizagem/diagnóstico , Adulto , Idoso , Análise de Variância , Feminino , Humanos , Masculino , Prontuários Médicos , Entrevista Psiquiátrica Padronizada , Pessoa de Meia-Idade , Exame Neurológico , Inquéritos e Questionários
15.
Pediatr Neurol ; 5(1): 32-6, 1989.
Artigo em Inglês | MEDLINE | ID: mdl-2712936

RESUMO

Questionnaires were submitted to 163 board-certified/eligible child neurologists to determine whether they employed a consistent approach to the mental status examination of children with learning problems and whether this approach appropriately emphasized the assessment of higher and related cortical functions. The responders' frequency of testing in 6 major categories of mental status function was independent of their age, sex, board-certified/eligible status, type of practice, and years elapsed since completion of training. The results of the entire study group and comparisons among demographic subgroups demonstrated a progressive decline in testing frequency with increasing complexity of mental status function. Child neurologists' approach to the mental status examination was remarkably uniform across a wide range of demographic variables. Higher and related cortical functions are tested significantly less often in children with learning problems than are other more elementary categories of mental status function; therefore, the importance of the mental status examination in this context must be questioned. It is likely that the diagnosis ascribed to a child with learning problems is based on findings other than those provided by the mental status examination.


Assuntos
Competência Clínica , Deficiências da Aprendizagem/psicologia , Processos Mentais/fisiologia , Neurologia/normas , Criança , Humanos , Deficiências da Aprendizagem/fisiopatologia , Exame Neurológico , Inquéritos e Questionários
16.
J Perinatol ; 21(5): 293-9, 2001.
Artigo em Inglês | MEDLINE | ID: mdl-11536022

RESUMO

OBJECTIVE: To determine if preterm infants of higher-order multiple (HOM) gestations have a significantly worse outcome during hospital stay when compared with preterm twins. STUDY DESIGN: Retrospective cohort analysis. METHODS: Perinatal outcome variables including gestational age (GA), birthweight, prenatal steroid use, cesarean section delivery rate, Apgar scores, and growth retardation were analyzed for 106 preterm HOM births (triplets and quadruplets) versus 328 preterm twins admitted to a single tertiary level neonatal intensive care unit. A comparison of the mortality and major neonatal morbidities such as respiratory distress syndrome, patent ductus arteriosus, intraventricular hemorrhage, necrotizing enterocolitis, bronchopulmonary dysplasia, and retinopathy of prematurity was made for these two groups. In addition, the duration of respiratory support including surfactant therapy, nasal continuous positive airway pressure, and mechanical ventilation, as well as the length of hospitalization, was analyzed. RESULTS: There were no significant differences in major morbidities between the infants of HOM and twin births of similar GA. There was no statistically significant difference in mortality, but the data showed a trend for lesser mortality in HOM. There was a highly significant increase in antenatal steroid use as well as the use of cesarean section for delivery in the HOM when compared with twin gestations. The infants of HOM gestations were of significantly lower birthweight than the twins and had a longer hospitalization. CONCLUSION: Although premature infants of HOM had lower birthweight and needed a longer hospital stay, their mortality and morbidity at hospital discharge were not worse than that for preterm twins.


Assuntos
Doenças em Gêmeos/epidemiologia , Doenças do Prematuro/mortalidade , Gravidez Múltipla/estatística & dados numéricos , Adulto , Peso ao Nascer , Causas de Morte , Connecticut/epidemiologia , Feminino , Morte Fetal/epidemiologia , Idade Gestacional , Humanos , Recém-Nascido , Unidades de Terapia Intensiva Neonatal/estatística & dados numéricos , Masculino , Gravidez , Quadrigêmeos , Análise de Regressão , Trigêmeos
17.
J Reprod Med ; 35(2): 152-4, 1990 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-2304038

RESUMO

The cyclic variation in fetal heart rate (FHR) patterns in preterm fetuses throughout labor was studied with a retrospective analysis of 49 FHR tracings. All fetuses were born preterm in good condition, and 92% exhibited the ability to change FHR cycles. A cycle was defined as an FHR pattern with consistent long-term variability in terms of amplitude range. The FHR cycles were significantly shorter in the second stage of labor as compared to the latent and active phases. Cycles of markedly diminished variability (less than or equal to 2.5 beats per minute) were observed in 16% of the fetuses during the latent phase and had a mean duration of 42 minutes, in 21% of the fetuses during the active phase with a mean duration of 68.3 minutes and in 8% of the fetuses during the second stage with a mean duration of 28.5 minutes. Knowledge of the normal length and frequency of FHR cycles is imperative for the correct interpretation of intrapartum FHR patterns in preterm fetuses.


Assuntos
Frequência Cardíaca Fetal/fisiologia , Trabalho de Parto Prematuro/fisiopatologia , Periodicidade , Feminino , Humanos , Recém-Nascido , Gravidez , Estudos Retrospectivos
18.
Indian J Pediatr ; 64(4): 529-35, 1997.
Artigo em Inglês | MEDLINE | ID: mdl-10771883

RESUMO

Catheter-related sepsis is commonly encountered in the neonatal intensive care unit. We retrospectively studied infants with vascular catheters at 2 NICUs. Data were obtained from the computerised admission records available at both the hospitals. Our aims were to describe the clinical and microbial profile of nosocomial sepsis in infants with vascular catheters [umbilical artery (UA), umbilical venous (UV), central venous Broviac (CV), percutaneously placed central venous (PC), peripheral artery (PA)], and to determine the association between catheter type, duration and sepsis in a subset of the population. Nosocomial sepsis (positive blood culture after the 3rd postnatal day) occurred in 217 of 2091 (10.4%) infants. Infected infants, in contrast to non-infected, had a significantly (P < 0.001) greater number of multiple catheters (2.3 vs 1.4) had lower birth weights (1.2 vs 2.1 kg), were younger (28 vs 33 weeks) and had lower 1 and 5 minute Apgar scores (4.3 and 6.7 vs 5.5 and 7.4). The most common organism was coagulase negative Staphylococcus. In a subset population as analyses revealed, longer duration of UA use was associated with higher infection rates [13.6% with UA use for > or = 8 days vs 1.3% for < or = 7 days (P < 0.0001)]. PC use had a lower rate of sepsis than CV use (5.1% vs 15.2%; P < 0.05). Use of intravascular catheters should be balanced between the need for vascular access and the risk of sepsis.


Assuntos
Cateterismo/efeitos adversos , Infecção Hospitalar/etiologia , Unidades de Terapia Intensiva Neonatal , Sepse/etiologia , Cateterismo/instrumentação , Connecticut/epidemiologia , Infecção Hospitalar/epidemiologia , Infecção Hospitalar/microbiologia , Infecção Hospitalar/prevenção & controle , Feminino , Humanos , Recém-Nascido , Recém-Nascido Prematuro , Masculino , Estudos Retrospectivos , Sepse/epidemiologia , Sepse/microbiologia , Sepse/prevenção & controle
19.
Conn Med ; 59(1): 3-9, 1995 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-7859445

RESUMO

We reviewed vital statistics (1987-92) and hospital discharge data (1987-91) for Connecticut residents to describe the epidemiology of bicycle-related injuries in the state. Each year there are approximately eight deaths (rate = 0.25/100,000) and 289 hospitalizations (rate = 8.8/100,000) due to bicycle related injury. Nonfatal bicycle injuries resulted in 1,500 hospital days at a cost of $1.7 million dollars. Death and hospitalization rates are highest among male children and adolescents five to 19 years of age. Most of the mortality and serious morbidity from bicycle-related trauma is due to head injuries. Both fatal and nonfatal bicycle head injury rates are highest in towns with a population less than 50,000 residents. Bicycle-related head injury is an important cause of mortality and morbidity of Connecticut children and youth and is largely preventable through the use of bicycle helmets. The data presented here allow for the development, implementation, and evaluation of community-based bicycle safety and helmet programs.


Assuntos
Acidentes de Trânsito/estatística & dados numéricos , Ciclismo/lesões , Traumatismos Craniocerebrais/epidemiologia , Acidentes de Trânsito/mortalidade , Adolescente , Adulto , Idoso , Ciclismo/estatística & dados numéricos , Criança , Pré-Escolar , Connecticut/epidemiologia , Traumatismos Craniocerebrais/mortalidade , Feminino , Hospitalização/estatística & dados numéricos , Humanos , Lactente , Masculino , Pessoa de Meia-Idade , Traumatismo Múltiplo/epidemiologia
20.
Conn Med ; 62(6): 323-31, 1998 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-9675991

RESUMO

We reviewed vital statistics (1988-95) and hospital discharge data (1990-94) for Connecticut children and youth to describe the epidemiology of childhood injuries. There are approximately 175 deaths (rate = 21/100,000) and 4,230 hospitalizations (rate = 468/100,000) annually due to injury. Nonfatal injuries resulted in over 94,000 hospital days at a cost of nearly $155 million dollars. Death and hospitalization rates are highest among male children and adolescents 15 to 19 years of age. Geographic analysis of injury revealed significantly higher injury death and hospitalization rates in towns greater than 100,000 population. In addition, a majority of the homicides occurred in large urban areas, and most of the motor vehicle occupant deaths and suicides occurred in suburban and rural areas. Injury is an important cause of mortality and morbidity in youth and is largely preventable. The data presented here allow for the development, implementation, and evaluation of community based injury prevention programs.


Assuntos
Ferimentos e Lesões/epidemiologia , Acidentes de Trânsito/mortalidade , Adolescente , Adulto , Fatores Etários , Criança , Pré-Escolar , Connecticut/epidemiologia , Feminino , Homicídio/estatística & dados numéricos , Hospitalização/estatística & dados numéricos , Humanos , Lactente , Tempo de Internação/estatística & dados numéricos , Masculino , Alta do Paciente/estatística & dados numéricos , População , Saúde da População Rural/estatística & dados numéricos , Fatores Sexuais , Saúde Suburbana/estatística & dados numéricos , Suicídio/estatística & dados numéricos , Saúde da População Urbana/estatística & dados numéricos , Estatísticas Vitais , Ferimentos e Lesões/mortalidade , Ferimentos e Lesões/prevenção & controle
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