Detalhe da pesquisa
1.
Enantiomers of 4-aminopentanoic acid act as false GABAergic neurotransmitters and impact mouse behavior.
J Neurochem
; 158(5): 1074-1082, 2021 09.
Artigo
Inglês
| MEDLINE | ID: mdl-34273193
2.
Publisher Correction: The Jumonji-C oxygenase JMJD7 catalyzes (3S)-lysyl hydroxylation of TRAFAC GTPases.
Nat Chem Biol
; 14(10): 988, 2018 Oct.
Artigo
Inglês
| MEDLINE | ID: mdl-29950663
3.
The Jumonji-C oxygenase JMJD7 catalyzes (3S)-lysyl hydroxylation of TRAFAC GTPases.
Nat Chem Biol
; 14(7): 688-695, 2018 07.
Artigo
Inglês
| MEDLINE | ID: mdl-29915238
4.
Cation-π Interactions Contribute to Substrate Recognition in γ-Butyrobetaine Hydroxylase Catalysis.
Chemistry
; 22(4): 1270-6, 2016 Jan 22.
Artigo
Inglês
| MEDLINE | ID: mdl-26660433
5.
Discovery of 1H-Pyrazole Biaryl Sulfonamides as Novel G2019S-LRRK2 Kinase Inhibitors.
ACS Med Chem Lett
; 13(6): 981-988, 2022 Jun 09.
Artigo
Inglês
| MEDLINE | ID: mdl-35707141
6.
Discovery of G2019S-Selective Leucine Rich Repeat Protein Kinase 2 inhibitors with in vivo efficacy.
Eur J Med Chem
; 229: 114080, 2022 Feb 05.
Artigo
Inglês
| MEDLINE | ID: mdl-34992038
7.
Discovery of azaspirocyclic 1H-3,4,5-Trisubstitued pyrazoles as novel G2019S-LRRK2 selective kinase inhibitors.
Eur J Med Chem
; 242: 114693, 2022 Nov 15.
Artigo
Inglês
| MEDLINE | ID: mdl-36049274
8.
Imitation of ß-lactam binding enables broad-spectrum metallo-ß-lactamase inhibitors.
Nat Chem
; 14(1): 15-24, 2022 01.
Artigo
Inglês
| MEDLINE | ID: mdl-34903857
9.
Enantiomers of 2-methylglutamate and 2-methylglutamine selectively impact mouse brain metabolism and behavior.
Sci Rep
; 11(1): 8138, 2021 04 14.
Artigo
Inglês
| MEDLINE | ID: mdl-33854131
10.
19F NMR studies on γ-butyrobetaine hydroxylase provide mechanistic insights and suggest a dual inhibition mode.
Chem Commun (Camb)
; 55(98): 14717-14720, 2019 Dec 05.
Artigo
Inglês
| MEDLINE | ID: mdl-31702759
11.
Small-molecules that covalently react with a human prolyl hydroxylase - towards activity modulation and substrate capture.
Chem Commun (Camb)
; 55(8): 1020-1023, 2019 Jan 22.
Artigo
Inglês
| MEDLINE | ID: mdl-30452037
12.
Development of mutation-selective LRRK2 kinase inhibitors as precision medicine for Parkinson's disease and other diseases for which carriers are at increased risk.
Front Neurol
; 13: 1016040, 2022.
Artigo
Inglês
| MEDLINE | ID: mdl-36388213
13.
Targeting LRRK2 mutations in Parkinson's disease.
Future Med Chem
; 14(16): 1167-1170, 2022 08.
Artigo
Inglês
| MEDLINE | ID: mdl-35730403
14.
Human carnitine biosynthesis proceeds via (2S,3S)-3-hydroxy-Nε-trimethyllysine.
Chem Commun (Camb)
; 53(2): 440-442, 2016 12 22.
Artigo
Inglês
| MEDLINE | ID: mdl-27965989