Pesquisa | Secretaria de Estado da Saúde

1.

Heterogeneity and transcriptional drivers of triple-negative breast cancer.

Jovanovic, Bojana; Temko, Daniel; Stevens, Laura E; Seehawer, Marco; Fassl, Anne; Murphy, Katherine; Anand, Jayati; Garza, Kodie; Gulvady, Anushree; Qiu, Xintao; Harper, Nicholas W; Daniels, Veerle W; Xiao-Yun, Huang; Ge, Jennifer Y; Aleckovic, Masa; Pyrdol, Jason; Hinohara, Kunihiko; Egri, Shawn B; Papanastasiou, Malvina; Vadhi, Raga; Font-Tello, Alba; Witwicki, Robert; Peluffo, Guillermo; Trinh, Anne; Shu, Shaokun; Diciaccio, Benedetto; Ekram, Muhammad B; Subedee, Ashim; Herbert, Zachary T; Wucherpfennig, Kai W; Letai, Anthony G; Jaffe, Jacob D; Sicinski, Piotr; Brown, Myles; Dillon, Deborah; Long, Henry W; Michor, Franziska; Polyak, Kornelia.

Cell Rep ; 42(12): 113564, 2023 12 26.

Artigo Inglês | MEDLINE | ID: mdl-38100350

2.

Aurora kinase A is a target of Wnt/beta-catenin involved in multiple myeloma disease progression.

Dutta-Simmons, Jui; Zhang, Yunyu; Gorgun, Gullu; Gatt, Moshe; Mani, Mala; Hideshima, Teru; Takada, Kohichi; Carlson, Nicole E; Carrasco, Daniel E; Tai, Yu-Tzu; Raje, Noopur; Letai, Anthony G; Anderson, Kenneth C; Carrasco, Daniel R.

Blood ; 114(13): 2699-708, 2009 Sep 24.

Artigo Inglês | MEDLINE | ID: mdl-19652203

3.

Multiple screening approaches reveal HDAC6 as a novel regulator of glycolytic metabolism in triple-negative breast cancer.

Dowling, Catríona M; Hollinshead, Kate E R; Di Grande, Alessandra; Pritchard, Justin; Zhang, Hua; Dillon, Eugene T; Haley, Kathryn; Papadopoulos, Eleni; Mehta, Anita K; Bleach, Rachel; Lindner, Andreas U; Mooney, Brian; Düssmann, Heiko; O'Connor, Darran; Prehn, Jochen H M; Wynne, Kieran; Hemann, Michael; Bradner, James E; Kimmelman, Alec C; Guerriero, Jennifer L; Cagney, Gerard; Wong, Kwok-Kin; Letai, Anthony G; Chonghaile, Tríona Ní.

Sci Adv ; 7(3)2021 01.

Artigo Inglês | MEDLINE | ID: mdl-33523897

4.

Mitochondrial Reprogramming Underlies Resistance to BCL-2 Inhibition in Lymphoid Malignancies.

Guièze, Romain; Liu, Vivian M; Rosebrock, Daniel; Jourdain, Alexis A; Hernández-Sánchez, María; Martinez Zurita, Aina; Sun, Jing; Ten Hacken, Elisa; Baranowski, Kaitlyn; Thompson, Philip A; Heo, Jin-Mi; Cartun, Zachary; Aygün, Ozan; Iorgulescu, J Bryan; Zhang, Wandi; Notarangelo, Giulia; Livitz, Dimitri; Li, Shuqiang; Davids, Matthew S; Biran, Anat; Fernandes, Stacey M; Brown, Jennifer R; Lako, Ana; Ciantra, Zoe B; Lawlor, Matthew A; Keskin, Derin B; Udeshi, Namrata D; Wierda, William G; Livak, Kenneth J; Letai, Anthony G; Neuberg, Donna; Harper, J Wade; Carr, Steven A; Piccioni, Federica; Ott, Christopher J; Leshchiner, Ignaty; Johannessen, Cory M; Doench, John; Mootha, Vamsi K; Getz, Gad; Wu, Catherine J.

Cancer Cell ; 36(4): 369-384.e13, 2019 10 14.

Artigo Inglês | MEDLINE | ID: mdl-31543463

5.

PRC2 loss induces chemoresistance by repressing apoptosis in T cell acute lymphoblastic leukemia.

Ariës, Ingrid M; Bodaar, Kimberly; Karim, Salmaan A; Chonghaile, Triona Ni; Hinze, Laura; Burns, Melissa A; Pfirrmann, Maren; Degar, James; Landrigan, Jack T; Balbach, Sebastian; Peirs, Sofie; Menten, Björn; Isenhart, Randi; Stevenson, Kristen E; Neuberg, Donna S; Devidas, Meenakshi; Loh, Mignon L; Hunger, Stephen P; Teachey, David T; Rabin, Karen R; Winter, Stuart S; Dunsmore, Kimberly P; Wood, Brent L; Silverman, Lewis B; Sallan, Stephen E; Van Vlierberghe, Pieter; Orkin, Stuart H; Knoechel, Birgit; Letai, Anthony G; Gutierrez, Alejandro.

J Exp Med ; 215(12): 3094-3114, 2018 12 03.

Artigo Inglês | MEDLINE | ID: mdl-30404791

6.

Overcoming mutational complexity in acute myeloid leukemia by inhibition of critical pathways.

Saito, Yoriko; Mochizuki, Yoshiki; Ogahara, Ikuko; Watanabe, Takashi; Hogdal, Leah; Takagi, Shinsuke; Sato, Kaori; Kaneko, Akiko; Kajita, Hiroshi; Uchida, Naoyuki; Fukami, Takehiro; Shultz, Leonard D; Taniguchi, Shuichi; Ohara, Osamu; Letai, Anthony G; Ishikawa, Fumihiko.

Sci Transl Med ; 9(413)2017 Oct 25.

Artigo Inglês | MEDLINE | ID: mdl-29070697

7.

Cristae remodeling causes acidification detected by integrated graphene sensor during mitochondrial outer membrane permeabilization.

Pham, Ted D; Pham, Phi Q; Li, Jinfeng; Letai, Anthony G; Wallace, Douglas C; Burke, Peter J.

Sci Rep ; 6: 35907, 2016 10 27.

Artigo Inglês | MEDLINE | ID: mdl-27786282

8.

Selective BCL-2 inhibition by ABT-199 causes on-target cell death in acute myeloid leukemia.

Pan, Rongqing; Hogdal, Leah J; Benito, Juliana M; Bucci, Donna; Han, Lina; Borthakur, Gautam; Cortes, Jorge; DeAngelo, Daniel J; Debose, Lakeisha; Mu, Hong; Döhner, Hartmut; Gaidzik, Verena I; Galinsky, Ilene; Golfman, Leonard S; Haferlach, Torsten; Harutyunyan, Karine G; Hu, Jianhua; Leverson, Joel D; Marcucci, Guido; Müschen, Markus; Newman, Rachel; Park, Eugene; Ruvolo, Peter P; Ruvolo, Vivian; Ryan, Jeremy; Schindela, Sonja; Zweidler-McKay, Patrick; Stone, Richard M; Kantarjian, Hagop; Andreeff, Michael; Konopleva, Marina; Letai, Anthony G.

Cancer Discov ; 4(3): 362-75, 2014 Mar.

Artigo Inglês | MEDLINE | ID: mdl-24346116

9.

Smallpox and smallpox vaccination.

Letai, Anthony G.

N Engl J Med ; 348(19): 1920-5; author reply 1920-5, 2003 May 08.

Artigo Inglês | MEDLINE | ID: mdl-12736287

10.

Diagnosing and exploiting cancer's addiction to blocks in apoptosis.

Letai, Anthony G.

Nat Rev Cancer ; 8(2): 121-32, 2008 Feb.

Artigo Inglês | MEDLINE | ID: mdl-18202696

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