Psychometric properties of Chinese Translated body compassion scale (BCS) among Hong Kong adolescents.

BACKGROUND: Adolescence is at a transition stage of developmental psychology, and they must go through their psychosocial and identity crisis, which affect their self-concept. According to the structure of self-concept, physical is considered as one of the elements affecting a person's evolvement of self, which can be called as physical self-esteem. In regards to the equilibrium mental benefits of self-compassion, the concept of body compassion was focused. Together with the lack of body-part related research being further investigated among non-western countries, this research aimed at translating the Body Compassion Scale (BCS) to Chinese and examining the reliability and validity of the Chinese translated BCS among Hong Kong adolescents. METHODS: The reliability of the translated BCS was examined by the test-retest reliability test as well as the Cronbach's alpha value for the internal consistency. The confirmatory factor analysis (CFA) was adopted to investigate the construct validity, and Pearson's correlation was used to examine the convergent validity with other related scales. RESULTS: The Chinese translated BCS (Pilot Study: n = 220; Main Study: n = 1047) showed adequate psychometric properties results. It had a satisfying internal consistency and test-retest reliability. It showed an adequate goodness of fit results in CFA, with X 2(465.64)/227 = 2.05,p < 0.001, CFI = 0.916, TLI = 0.906,SRMR = 0.071,RMSEA = 0.069 [90% CI = 0.06 to 0.078]. Additionally, the measurement invariance model suggested that the factor loadings and mean differences of the translated BCS were invariant across early and older adolescents. CONCLUSION: The Chinese translated BCS is considered as valid and reliable in examining Hong Kong adolescents' body compassion.

Associations Between Social and Physical Environments and Older Adults' Walking for Transportation and Recreation.

This study examined the associations between physical environment, social environment, and walking for transportation and recreation among older adults in Hong Kong. Cross-sectional data from 450 older adults (79 years or younger [71.9%], female [79.7%]) from 18 districts in Hong Kong were used. The participants' perceptions of their physical and social environments were collected and their walking behaviors were self-reported. The results revealed that positive physical environment-facilitators and social environments were associated with increased total walking. Only positive physical environment-facilitators were associated with increased walking for transportation, and physical and social environments had no notable effect on walking for recreation. These findings suggest that policymakers and walking intervention designers should develop strategies to enhance physical and social environments to promote total walking and walking for transportation.

Regulation of chromatin architecture by the PWWP domain-containing DNA damage-responsive factor EXPAND1/MUM1.

Dynamic changes of chromatin structure facilitate diverse biological events, including DNA replication, repair, recombination, and gene transcription. Recent evidence revealed that DNA damage elicits alterations to the chromatin to facilitate proper checkpoint activation and DNA repair. Here we report the identification of the PWWP domain-containing protein EXPAND1/MUM1 as an architectural component of the chromatin, which in response to DNA damage serves as an accessory factor to promote cell survival. Depletion of EXPAND1/MUM1 or inactivation of its PWWP domain resulted in chromatin compaction. Upon DNA damage, EXPAND1/MUM1 rapidly concentrates at the vicinity of DNA damage sites via its direct interaction with 53BP1. Ablation of this interaction impaired damage-induced chromatin decondensation, which is accompanied by sustained DNA damage and hypersensitivity to genotoxic stress. Collectively, our study uncovers a chromatin-bound factor that serves an accessory role in coupling damage signaling with chromatin changes in response to DNA damage.

Psychometric Properties of Eight-Item Physical Activity Enjoyment Scale in a Chinese Population.

This study examined the psychometric properties of the eight-item Physical Activity Enjoyment Scale (PACES) in Hong Kong older adults. Study 1 assessed the scale's factor validity and test-retest reliability, whereas Study 2 examined its convergent validity in Hong Kong older adults. A total of 168 (Study 1) older adults completed the PACES twice over a 2-week interval, and 57 (Study 2) older adults completed both the eight-item PACES and a measure of quality of life. The results of both studies showed that the eight-item PACES had a high degree of internal consistency. Both the composite reliability and average variance extracted from Study 1 were high, suggesting that as a set, the eight items of the PACES reliably measured the construct. The observed test-retest reliability was satisfactory over a 2-week interval. This eight-item PACES is an expedited and reliable instrument for assessing physical activity enjoyment in Chinese older adults.

Psychometric Properties of the Modified Social Environment Questionnaire in Chinese Older Adults.

This study evaluated the psychometric properties of a Chinese version of the 24-item Social Environment Questionnaire (SEQ-C). Confirmatory factor analysis was used to examine the factor validity and measurement invariance (Purpose 1) of the SEQ-C in 453 older adults in Hong Kong. Convergent validity (Purpose 2) and test-retest reliability (Purpose 3) were also measured. The results of the confirmatory factor analysis and measurement invariance supported the four-factor structure (representing companionship, encouragement, neighborhood social cohesion, and role models) of the SEQ-C, in a 15-item model that closely fitted the data. The SEQ-C was also found to have acceptable to satisfactory internal consistency, test-retest reliability, composite reliability, and moderate convergent validity in correlating perceived social support. This study showed that the SEQ-C is a suitable means of measuring the social environments of older adults in Hong Kong.

Designing an eSports intervention for middle-aged and older adults in Hong Kong: Social marketing approach.

This study examined the perceptions and experiences of middle-aged and older adult participants in electronic sports (eSports) in Hong Kong (HK), China, by using the social marketing (SM) approach. This qualitative study applied SM approach to the design of a center-based eSports intervention for middle-aged and older adults in HK. Interviews were conducted with 39 adults stratified in terms of age (i.e., 45-64 vs. ≥65 years) and experience with eSports. Ten administrators working in community elderly centers were invited for semistructured interviews. Thematic analysis was performed on the data by incorporating SM. Main findings are presented in terms of five P's. The product component of an eSports intervention includes the foundation of eSports (e.g., safety, eSports training), suitable games for older adults, and professional equipment (e.g., large-screen devices and motion-controlled Nintendo Switches). The price component comprises affordability and the frequency and duration of each eSport session, and the place component includes accessibility and spaces to play eSports. The promotion component should be educational in nature and can incorporate free trials and gaming days, short films about older adults playing eSports, promotional channels, physical evidence and annual eSports competitions. The people component consists of support from administrators and the center in charge, the availability of skilled program instructors and staff, and appropriate partnering, team sizes and instructor-to-participant ratios. The 5P's enhance the design of future center-based eSports interventions and can help researchers and practitioners determine which aspects encourage middle-aged and older adults to participate in eSports.

Redevelopment and Examination of the Psychometric Properties of the Chinese Version of the Last 7-Day Sedentary Behaviour Questionnaire (SIT-Q-7d-Chi) in Hong Kong Older Adults.

(1) Background: This study examined the psychometric properties of the Chinese version of the Last 7-Day Sedentary Behaviour Questionnaire (SIT-Q-7d-Chi) in Hong Kong older adults; (2) Methods: Study 1 assessed the questionnaire's test-retest reliability, and Study 2 examined its validity. Place the question addressed in a broad context and highlight the purpose of the study; (3) Results: In Study 1, 84 older adults (aged 60-90) completed the SIT-Q-7d-Chi twice over a 2-week interval, and in Study 2, 38 older adults (i) completed the SIT-Q-7d-Chi and the Sedentary Behaviour Questionnaire for Older Adults (SBQOA) and (ii) wore a waist-mounted accelerometer for 7 consecutive days. In Study 1, the SIT-Q-7d-Chi's test-retest reliability (ICC = 0.91-0.99) was satisfactory, and adequate internal consistency was found for most domains of the SIT-Q-7d-Chi (Cronbach's alpha value being 0.7 or above). Study 2's results showed that the SIT-Q-7d-Chi results were significantly correlated with the SBQOA results, but not with the accelerometer results; (4) Conclusions: This study revealed the prevalence of sedentary behavior among Hong Kong's senior citizens, which can be used as a reference to plan or evaluate a future sedentary behavior intervention for older persons, including identifying the content and intensity of activities.

The Spectral Extent of Phasic Suppression of Loudness and Distortion-Product Otoacoustic Emissions by Infrasound and Low-Frequency Tones.

We investigated the effect of a biasing tone close to 5, 15, or 30 Hz on the response to higher-frequency probe tones, behaviorally, and by measuring distortion-product otoacoustic emissions (DPOAEs). The amplitude of the biasing tone was adjusted for criterion suppression of cubic DPOAE elicited by probe tones presented between 0.7 and 8 kHz, or criterion loudness suppression of a train of tone-pip probes in the range 0.125-8 kHz. For DPOAEs, the biasing-tone level for criterion suppression increased with probe-tone frequency by 8-9 dB/octave, consistent with an apex-to-base gradient of biasing-tone-induced basilar membrane displacement, as we verified by computational simulation. In contrast, the biasing-tone level for criterion loudness suppression increased with probe frequency by only 1-3 dB/octave, reminiscent of previously published data on low-side suppression of auditory nerve responses to characteristic frequency tones. These slopes were independent of biasing-tone frequency, but the biasing-tone sensation level required for criterion suppression was ~ 10 dB lower for the two infrasound biasing tones than for the 30-Hz biasing tone. On average, biasing-tone sensation levels as low as 5 dB were sufficient to modulate the perception of higher frequency sounds. Our results are relevant for recent debates on perceptual effects of environmental noise with very low-frequency content and might offer insight into the mechanism underlying low-side suppression.

An epididymis-specific beta-defensin is important for the initiation of sperm maturation.

Although the role of the epididymis, a male accessory sex organ, in sperm maturation has been established for nearly four decades, the maturation process itself has not been linked to a specific molecule of epididymal origin. Here we show that Bin1b, a rat epididymis-specific beta-defensin with antimicrobial activity, can bind to the sperm head in different regions of the epididymis with varied binding patterns. In addition, Bin1b-expressing cells, either of epididymal origin or from a Bin1b-transfected cell line, can induce progressive sperm motility in immotile immature sperm. This induction of motility is mediated by the Bin1b-induced uptake of Ca(2+), a mechanism that has a less prominent role in maintaining motility in mature sperm. In vivo antisense experiments show that suppressed expression of Bin1b results in reduced binding of Bin1b to caput sperm and in considerable attenuation of sperm motility and progressive movement. Thus, beta-defensin is important for the acquisition of sperm motility and the initiation of sperm maturation.

Physical and psychological health outcomes of a sitting light volleyball intervention program on adults with physical disabilities: a non-randomized controlled pre-post study.

BACKGROUND: People with physical disabilities (PWPD) have limited opportunities to participate in sport activities. Sitting light volleyball (SLVB) is an adapted sport that combines light volleyball and paralympic sitting volleyball. This study examined the effectiveness of an SLVB intervention program to improve the physical and psychological health outcomes of PWPD in Hong Kong, China. METHODS: Thirty-two PWPD [13 women; SLVB group, n = 18; control group (CG), n = 14] with an average age of 48.89 years (SD = 14.42 years) participated in a 16-week intervention consisting of basic SLVB skills, and they also received instructions on the required posture, team tactics, and SLVB rules. Physical (i.e., muscular strength, muscular endurance, body composition, flexibility, and aerobic endurance) and psychological (i.e., physical activity enjoyment and quality of life) health outcomes were measured before and after the intervention. RESULTS: Individuals in the SLVB group exhibited statistically significant improvements in cardiovascular endurance [F(1,29) = 4.23, p = .049], body composition [F(1,23) = 6.67, p = .017], and physical activity enjoyment [F(1,29) = 16.94, p = .001] compared with adults in the CG. CONCLUSIONS: Participating in SLVB has physical and psychological benefits for adults with physical disabilities in this study. Registration number of trial registry: The trial is registered at chictr.org.cn, number ChiCTR2000032971 on 17/05/2020.

Examining the Exercise and Self-Esteem Model Revised with Self-Compassion among Hong Kong Secondary School Students Using Structural Equation Modeling.

The association between physical activity in achieving mental health benefits and subjective well-being is consistently identified by empirical research. The causation of a positive self-concept created by physical exercise is empirically supported by Sonstroem and Morgan's (1988) exercise and self-esteem model (EXSEM). However, various drawbacks of maintaining high self-esteem have been identified; thus, the concept of self-compassion was conjectured to be a form of "true self-esteem." Hence, the current study aimed to investigate the relationship between physical activity and self-compassion by examining the exercise and self-esteem model revised with self-compassion (EXSEM-SC). This study recruited secondary school students from Hong Kong using convenience sampling. The structural equation modeling (SEM) approach, including path analysis and multiple indicators, multiple causes (MIMIC) modeling, were used to reveal the results of the study. The results (n = 1097) indicated that the relationship between physical activity and self-compassion could be demonstrated by the EXSEM-SC, with a satisfactory goodness-of-fit index in the SEMs. The SEM also demonstrated the direct paths from physical activity to self-compassion and mental well-being, indicating the significant effect of physical activity on self-compassion.

Perception of Hong Kong Teenagers and Young Adults on Esports Participation: A Qualitative Study Using Theory of Planned Behavior.

Esports is a rapidly growing industry worldwide, and it is making significant inroads in Hong Kong as well. However, owing to debates regarding the distinction between Esports and video gaming and the potential negative effects of engaging in Esports, its development in Hong Kong is still in its infancy. Therefore, this qualitative study investigated the perceptions and attitudes of teenagers and young adults toward Esports development and engagement, using the theory of planned behavior. Twenty-five teenagers and young adults (male = 24, female =1) participated in this study, with their ages ranging from 15 to 29 years. Our results revealed the views of Hong Kong teenagers and young adults on the beneficial and deleterious outcomes (goal setting and achievement, physical health, socialization and teamwork, psychological benefits, academics and time distribution, physical strain, negative social image, and perception toward sport participation), subjective norms (parents, peers, teachers, and modeling effect), and barriers and facilitators (balance between academics and Esports, capability, career prospects and future reality, psychological benefits, and peer encouragement and support) of participating in Esports. Additionally, the results of this qualitative study may contribute toward a deeper understanding of Hong Kong Esports players to develop a theory of planned behavior construct for capturing the beliefs and perceptions of Hong Kong teenagers toward Esports.

Older Adults' Perceptions toward Walking: A Qualitative Study Using a Social-Ecological Model.

OBJECTIVES: In this study, we aimed to investigate older adults' perceptions of their walking experiences, using the social-ecological model as a guiding framework and to propose future walking intervention content. METHODS: Thirty-eight participants (19 women; 47% from private elderly centers; mean age = 72.8 (SD = 7.4 years) took part in semi-structured interviews. Qualitative data analysis software QSR-NVivo was used for thematic coding. RESULTS: Thematic deductive analysis revealed pertinent themes at the individual level (health benefits and barriers, fall risk, perseverance, and walking as a suitable activity for older adults), social environment level (social support and social interaction), physical environment level (density, land-use mix, and connectivity; perceived safety, pedestrian facilities (benches, quality of walking paths and sidewalks, and aesthetics), other pedestrian behaviors, and weather, and policy level (lack of walking programs in the community, and supportive culture for an active lifestyle). DISCUSSION: Our findings provide insights for the planning of future multilevel walking intervention programs for older adults in Hong Kong. It is suggested that future walking intervention should include professionals (e.g., physiotherapist or coach) in a group setting, practical walking recommendations such as proper walking posture, and additional fun activities for older adults.

Assessing Esports Participation Intention: The Development and Psychometric Properties of the Theory of Planned Behavior-Based Esports Intention Questionnaire (TPB-Esport-Q).

BACKGROUND: Esports is seen as an emerging industry that has enjoyed a surge in popularity worldwide. As a result, researchers have undertaken studies to try to understand the motivations and factors that impact Esports gameplay. Given the extensive utilization of TPB in many research projects to conceptualize and predict various behaviors, the current study aimed to further extend this theory to the Esports context by developing and validating an instrument that can illustrate the factors that impact the intention to participate in Esports, thus predicting Esports game playing behaviors. METHODS: A total of 25 participants were involved in the development of the questionnaire using the qualitative approach, while 915 university students and 1164 secondary school students were involved in the survey for the questionnaire validation using the exploratory factor analysis and the confirmatory factor analysis. RESULTS: All measurement models of the TPB subscales are considered as good fit. CONCLUSION: Hence, showing the newly designed TPB Esports Intention Questionnaire was found to be reliable and valid in revealing the level of intentions as well as the factors affecting Hong Kong students playing Esports.

Evaluation of a sitting light volleyball intervention to adults with physical impairments: qualitative study using social-ecological model.

BACKGROUND: This study was a part of 16-week sitting light volleyball (SLVB) intervention program which examined the effects of the intervention on the physical and psychological attributes of adults with physical impairments (PWPI) in Hong Kong. Gaining a deeper understanding of the perceptions and experiences of PWPI in the SLVB intervention is critical to the development of SLVB as a physical activity and a sport. The aims of this study were (a) to assess participants' experiences of the intervention and (b) to examine the suitability and feasibility of SLVB intervention for PWPI. METHODS: Twenty participants (mean age = 53.52 years, standard deviation 9.02 years; 60% female; 25% with at least a college degree) participated in semi-structured interviews. RESULTS: Content analysis revealed features of their experiences at the individual or intrapersonal level (physical and psychological health, enjoyment, novelty, competence, autonomy), interpersonal level (socialization and teamwork, social support), organizational and community levels (perceived sport venue environment, venue accessibility, safety, dissemination of information), and policy level (resources allocation by the government). The participants also commented on the suitability and feasibility of the SLVB intervention for PWPI, its content and coaching, the modified rules, the duration of sessions, scheduling, and the number of participants and coaches. CONCLUSIONS: This study identified several themes relevant to the promotion of PWPI engagement with SLVB and demonstrated that adopting a multilevel approach to the intervention resulted in positive outcomes for participants. Playing SLVB is suitable and feasible for PWPI. The findings contribute to the understanding of the experiences PWPI had of the SLVB intervention, which is critical to the further development of SLVB as a physical activity and a sport.

Speed of Processing and Personality: The Influence of Personality and Extrinsic Feedback on the Performance of Cognitive Tasks.

BACKGROUND: Feedback is considered as an effective means of motivating, guiding, and reinforcing desired behaviours. However, the ways to interpret external feedback may be different among individuals with different personality traits; therefore, this would influence the effects of feedback on performance. Accordingly, the influencing effects of personality towards different styles of feedback on cognitive task performance were examined. METHODS: Participants (N = 71) were given three Stroop tasks as a dependent variable, whereas the Trail Making Task was an independent variable; additionally, a personality test was used to record the personality traits of each participant. The relationship between personality and feedback-induced changes in Stroop performance was computed by means of Pearson correlation, followed by a mixed-effect model to demonstrate the effect of personality on the overall performance with feedback. RESULTS: The statistical analysis indicated that performance from those with higher levels of extraversion generally profitted from feedback, irrespective of whether it was negative feedback (r = 0.201) or positive feedback (r = 0.205). Additionally, the moderating effect of personality on feedback and performance was demonstrated. CONCLUSIONS: The limitations of the sample size and other external influences may have reduced the representativeness of the research. Nonetheless, more potential influencing factors need to be included and explored in future research.

Health of Youth in Transition in Hong Kong.

This study aimed to examine the impact of individual (level of vigorous physical activity (VPA) and frequency of using sports and recreation facilities), interpersonal (perceived social cohesion (PSC)), and neighborhood environmental (availability of sports and recreation facilities) factors on youths' health in transition in Hong Kong. A sample of 508 individuals aged 17-23 years from all Hong Kong council districts randomly completed validated questionnaires by telephone survey. Of 508, 302 individuals with complete data pertaining to address geocoding were selected for further analyses. Overall, more than half of them (56.3%) used sports and recreation facilities once per month or less. Structural equation modeling was used to examine the relationship among the studies' constructs. The results indicated that the proposed model sufficiently fitted the data (χ2 (24) = 32.23, p < .12; CFI = .977; SRMR = .051; RMSEA = .034 (90% CI = .000 to .061)). However, two items of PSC were sequentially removed due to their low standardized factor loadings (<.3). A structural model was reinserted into data analyses, and the modified model fitted the data well as indicated by fit indices (χ2 (11) = 15.29, p < .17; CFI = .987; SRMR = .054; RMSEA = .036 (90% CI = .000 to .075)). Only VPA (ß = .27, p = .0005) and PSC (ß = .12, p = .048) were significantly related to perceived health at an individual level. To promote youth health, the Hong Kong government may work with the business sector, community groups, or education institutions to develop community programs to keep youths active (especially VPA) and to build more cohesive, trustful relationships among youths in the neighborhood.

Promoting healthy ageing through light volleyball intervention in Hong Kong: study protocol for a randomised controlled trial.

BACKGROUND: Our pilot study has demonstrated improvements in health outcomes through participation in a new sport, light volleyball (LVB), among older adults. In response to the promising results of the LVB pilot study and the priority of allocating resources to the prevention of age-related fitness degradation by the Hong Kong (HKG) government, the present study aims to investigate the effectiveness of a LVB intervention on physical and psychological health attributes among older adults at a larger scale in HKG. METHODS/DESIGN: This study will apply both quantitative and qualitative methods with a large sample (approximately 315 participants). We will adopt a randomized controlled trial (RCT) design to further evaluate the effectiveness of a LVB intervention on health outcomes against a comparison group, Tai Chi (TC), and a control group (C). Older adults will be eligible to join the intervention if they are (a) aged 65 years and above; (b) living in the community independently; (c) absent of diagnosed cognitive impairment; (d) not regular participants in a structured PA program for two years preceding the study; and (e) able to achieve a passing score on the Timed-up-and-go test (TUG) and Abbreviated Mental Test (AMT).About 315 participants will be randomly assigned into 3 groups in 1:1:1 ratio. LVB group participants will receive 16-week LVB program; TC group will utilize a simplified 24-form Yang Style TC, and C group participants will be instructed to maintain their normal daily activity and join regular non-exercise social gatherings. Measurements will be collected before and after the intervention, and 6 months and 12 months after completion of the intervention. DISCUSSION: This intervention, if effective, will enhance older adult's physical and psychological health, and provide the data and evidence to support policymaking in relation to future PA promotion for older adults. TRIAL REGISTRATION NUMBER: ChiCTR1900026657.

The candidate tumor suppressor ING1b can stabilize p53 by disrupting the regulation of p53 by MDM2.

ING1b is a candidate tumor suppressor that can stimulate the transcriptional activity of p53 and inhibit cell proliferation. The molecular basis of how ING1b activates p53 function remains unclear. Here we show that ING1b could stimulate the activity of p53 by increasing the level and stability of the p53 protein. The stabilization and activation of p53 by ING1b could be reversed by MDM2 in a dose-dependent manner. Conversely, ING1b could reverse the inhibition and degradation of p53 caused by MDM2 in a dose-dependent manner. Furthermore, ING1b and MDM2 bound to p53 in a mutually exclusive manner. In agreement with these observations, we found that similarly to MDM2, ING1b binds to the NH(2)-terminal region of p53. These data suggest a model in which ING1b disrupts the interaction between p53 and MDM2, leading to the stabilization of p53 and growth inhibition.

Rescue of defective pancreatic secretion in cystic-fibrosis cells by suppression of a novel isoform of phospholipase C.

BACKGROUND: Cystic fibrosis is caused by mutations in the gene encoding an ion-transport protein, the cystic-fibrosis transmembrane conductance regulator (CFTR). Defective secretion of anions is the primary cause of many of the clinical manifestations of cystic fibrosis, including pancreatic insufficiency. We aimed to identify a molecular mechanism from which a new method to circumvent defective pancreatic secretion could be derived. METHODS: Multiple-human-tissue RT-PCR and semiquantitative RT-PCR analyses were used to examine gene expression. An antisense technique was used in conjunction with radioimmunoassay, Fura-2 spectrofluorometry, immunohistochemistry, and the short-circuit current technique (Ussing chamber) for elucidation of gene function and its application in rescuing defective pancreatic secretion. FINDINGS: We cloned a newly identified gene, NYD-SP27, which has structural similarity to an isoform of phospholipase C. NYD-SP27 was expressed endogenously in human pancreatic-duct cells and upregulated in cystic fibrosis. Suppression of NYD-SP27, by transfection of its antisense into human cystic-fibrosis pancreatic-duct cells, resulted in augmentation of phospholipase-C-coupled calcium-ion release and protein kinase C activity, improvement in the amount of mutated CFTR reaching the plasma membrane, and restoration of cAMP-activated pancreatic anion secretion. INTERPRETATION: NYD-SP27 exerts an inhibitory effect on phospholipase-C-coupled processes that depend on calcium ions and protein kinase C, including CFTR trafficking and function. Its upregulation in pancreatic-duct cells may reveal a previously unsuspected defect in cystic fibrosis contributing to pancreatic insufficiency, and thus represents a new target for pharmacological intervention in cystic fibrosis.