Detalhe da pesquisa
1.
Phase 1 and preclinical profiling of ESM-HDAC391, a myeloid-targeted histone deacetylase inhibitor, shows enhanced pharmacology and monocytopaenia.
Br J Clin Pharmacol
; 88(12): 5238-5256, 2022 12.
Artigo
Inglês
| MEDLINE | ID: mdl-35655123
2.
Preclinical models of arthritis for studying immunotherapy and immune tolerance.
Ann Rheum Dis
; 80(10): 1268-1277, 2021 10.
Artigo
Inglês
| MEDLINE | ID: mdl-34380700
3.
Inhibition of PAD4 activity is sufficient to disrupt mouse and human NET formation.
Nat Chem Biol
; 11(3): 189-91, 2015 Mar.
Artigo
Inglês
| MEDLINE | ID: mdl-25622091
4.
Optimisation of a novel series of potent and orally bioavailable azanaphthyridine SYK inhibitors.
Bioorg Med Chem Lett
; 26(19): 4606-4612, 2016 10 01.
Artigo
Inglês
| MEDLINE | ID: mdl-27578246
5.
Carboxylesterase-1 Assisted Targeting of HDAC Inhibitors to Mononuclear Myeloid Cells in Inflammatory Bowel Disease.
J Crohns Colitis
; 16(4): 668-681, 2022 May 10.
Artigo
Inglês
| MEDLINE | ID: mdl-34633041
6.
Discovery of GSK143, a highly potent, selective and orally efficacious spleen tyrosine kinase inhibitor.
Bioorg Med Chem Lett
; 21(20): 6188-94, 2011 Oct 15.
Artigo
Inglês
| MEDLINE | ID: mdl-21903390
7.
Novel Insights Into Rheumatoid Arthritis Through Characterization of Concordant Changes in DNA Methylation and Gene Expression in Synovial Biopsies of Patients With Differing Numbers of Swollen Joints.
Front Immunol
; 12: 651475, 2021.
Artigo
Inglês
| MEDLINE | ID: mdl-33968050
8.
BRD4 methylation by the methyltransferase SETD6 regulates selective transcription to control mRNA translation.
Sci Adv
; 7(22)2021 05.
Artigo
Inglês
| MEDLINE | ID: mdl-34039605
9.
Gamma-secretase-dependent cleavage of amyloid precursor protein regulates osteoblast behavior.
FASEB J
; 23(9): 2942-55, 2009 Sep.
Artigo
Inglês
| MEDLINE | ID: mdl-19376818
10.
Targeting Histone Deacetylases in Myeloid Cells Inhibits Their Maturation and Inflammatory Function With Limited Effects on Atherosclerosis.
Front Pharmacol
; 10: 1242, 2019.
Artigo
Inglês
| MEDLINE | ID: mdl-31736752
11.
Apoptosis in T cell acute lymphoblastic leukemia cells after cell cycle arrest induced by pharmacological inhibition of notch signaling.
Chem Biol
; 14(2): 209-19, 2007 Feb.
Artigo
Inglês
| MEDLINE | ID: mdl-17317574
12.
A comparative assessment of gamma-secretase activity in transgenic and non-transgenic rodent brain.
J Neurosci Methods
; 157(2): 246-52, 2006 Oct 30.
Artigo
Inglês
| MEDLINE | ID: mdl-16859750
13.
iPAD or PADi-'tablets' with therapeutic disease potential?
Curr Opin Chem Biol
; 33: 169-78, 2016 08.
Artigo
Inglês
| MEDLINE | ID: mdl-27372273
14.
Protein arginine deiminase 2 binds calcium in an ordered fashion: implications for inhibitor design.
ACS Chem Biol
; 10(4): 1043-53, 2015 Apr 17.
Artigo
Inglês
| MEDLINE | ID: mdl-25621824
15.
Novel aspects of accumulation dynamics and A beta composition in transgenic models of AD.
Neurobiol Aging
; 25(9): 1175-85, 2004 Oct.
Artigo
Inglês
| MEDLINE | ID: mdl-15312963
16.
Design and synthesis of highly potent benzodiazepine gamma-secretase inhibitors: preparation of (2S,3R)-3-(3,4-difluorophenyl)-2-(4-fluorophenyl)-4- hydroxy-N-((3S)-1-methyl-2-oxo-5- phenyl-2,3-dihydro-1H-benzo[e][1,4]-diazepin-3-yl)butyramide by use of an asymmetric Ireland-Claisen rearrangement.
J Med Chem
; 46(12): 2275-8, 2003 Jun 05.
Artigo
Inglês
| MEDLINE | ID: mdl-12773031
17.
Cerebrospinal fluid levels of beta-amyloid(42) in patients with Alzheimer's disease are related to the exon 2 polymorphism of the cathepsin D gene.
Neuroreport
; 13(10): 1291-4, 2002 Jul 19.
Artigo
Inglês
| MEDLINE | ID: mdl-12151789
18.
Epigenetic pathway targets for the treatment of disease: accelerating progress in the development of pharmacological tools: IUPHAR Review 11.
Br J Pharmacol
; 171(22): 4981-5010, 2014 Nov.
Artigo
Inglês
| MEDLINE | ID: mdl-25060293
19.
Progression and variability of TNBS colitis-associated inflammation in rats assessed by contrast-enhanced and T2-weighted MRI.
Inflamm Bowel Dis
; 15(4): 534-45, 2009 Apr.
Artigo
Inglês
| MEDLINE | ID: mdl-19058230
20.
Novel orally bioavailable gamma-secretase inhibitors with excellent in vivo activity.
J Med Chem
; 52(11): 3441-4, 2009 Jun 11.
Artigo
Inglês
| MEDLINE | ID: mdl-19432431