Study of dose perturbation parameters for eye shielding in megavoltage photon beam therapy.

Shielding blocks are frequently used to minimize dose and shield sensitive organs in radiation therapy. The blocks, which are made of high atomic number materials, produce significant dose perturbations in megavoltage photon beams. The effects of these perturbations are studied with special interest in the eye shielding in the treatment of head and neck malignancies. Optimum parameters for the treatment are suggested.

Determination of aerosol parameters from light-scattering data using an inverse Monte Carlo technique.

An inverse, Monte Carlo (IMC) technique is developed to solve the electromagnetic inverse-scattering problem from generally complex distributions of dielectric particles. One can verify the technique using simulated scattering data from aerosols composed of spherical dielectrics. The IMC method is found to give accurate inversion results even when the data have a signal-to-noise ratio to as low as 3:1.

Aerosol properties from spectral extinction and backscatter estimated by an inverse Monte Carlo method.

The feasibility of using a generalized stochastic inversion methodology to estimate aerosol size distributions accurately by use of spectral extinction, backscatter data, or both is examined. The stochastic method used, inverse Monte Carlo (IMC), is verified with both simulated and experimental data from aerosols composed of spherical dielectrics with a known refractive index. Various levels of noise are superimposed on the data such that the effect of noise on the stability and results of inversion can be determined. Computational results show that the application of the IMC technique to inversion of spectral extinction or backscatter data or both can produce good estimates of aerosol size distributions. Specifically, for inversions for which both spectral extinction and backscatter data are used, the IMC technique was extremely accurate in determining particle size distributions well outside the wavelength range. Also, the IMC inversion results proved to be stable and accurate even when the data had significant noise, with a signal-to-noise ratio of 3.

The effect of electrode size on transvenous defibrillation energy requirements: a prospective evaluation.

Recent technological advances have resulted in high success rates for implantation of nonthoracotomy defibrillation lead systems. Further decreases in defibrillator size, facilitating pectoral placement, will depend in part on lowering defibrillation energy requirements. The purpose of this study was to determine if endocardial defibrillation energy requirements are influenced by electrode size. Thirteen adult mongrel dogs were studied under general anesthesia. A 9 Fr integrated bipolar pace/sense/defibrillation electrode (cathode) was positioned transvenously at the RV apex. The second defibrillation electrode (anode) was positioned at the junction of the RA and SVC. Two diameters of the proximal electrode, 7 Fr and 11 Fr, were sequentially tested in random order in each animal. The DFT for each electrode was determined using a 50-V up-down method. Energy, leading edge voltage, and current, current distribution, and total resistance were measured. The mean defibrillation voltage threshold with the 11 Fr proximal electrode was significantly less than with the 7 Fr proximal electrode (551.1 +/- 76.5 V vs 588.5 +/- 54.6 V, P < 0.01). Similarly, the mean DFT with the 11 Fr electrode was less than with the 7 Fr electrode (20.7 +/- 5.7 J vs 23.3 +/- 4.4 J, P < 0.01). Lower DFTs were found using the larger electrode in 11 of the 13 animals studied. However, there was no difference in defibrillation lead impedance between the two electrode systems. Endocardial defibrillation energy requirements may be lowered with a larger diameter proximal electrode. The mechanism by which this occurs may be due to a more even distribution of current gradients with the larger electrode. Determination of the optimal electrode size requires evaluation in humans, as this may allow further reduction in defibrillation energy requirements and defibrillator size.