Detalhe da pesquisa
1.
From Quinoxaline, Pyrido[2,3-b]pyrazine and Pyrido[3,4-b]pyrazine to Pyrazino-Fused Carbazoles and Carbolines.
Molecules
; 23(11)2018 Nov 13.
Artigo
Inglês
| MEDLINE | ID: mdl-30428591
2.
Marine-Derived 2-Aminoimidazolone Alkaloids. Leucettamine B-Related Polyandrocarpamines Inhibit Mammalian and Protozoan DYRK & CLK Kinases.
Mar Drugs
; 15(10)2017 Oct 17.
Artigo
Inglês
| MEDLINE | ID: mdl-29039762
3.
cdc-like/dual-specificity tyrosine phosphorylation-regulated kinases inhibitor leucettine L41 induces mTOR-dependent autophagy: implication for Alzheimer's disease.
Mol Pharmacol
; 85(3): 441-50, 2014 Mar.
Artigo
Inglês
| MEDLINE | ID: mdl-24366666
4.
Design and Synthesis of Novel N-Benzylidene Derivatives of 3-Amino-4-imino-3,5-dihydro-4H-chromeno[2,3-d]pyrimidine under Microwave, In Silico ADME Predictions, In Vitro Antitumoral Activities and In Vivo Toxicity.
Pharmaceuticals (Basel)
; 17(4)2024 Apr 02.
Artigo
Inglês
| MEDLINE | ID: mdl-38675418
5.
Structure-Activity Relationship in the Leucettine Family of Kinase Inhibitors.
J Med Chem
; 65(2): 1396-1417, 2022 01 27.
Artigo
Inglês
| MEDLINE | ID: mdl-34928152
6.
Design and Microwave Synthesis of New (5Z) 5-Arylidene-2-thioxo-1,3-thiazolinidin-4-one and (5Z) 2-Amino-5-arylidene-1,3-thiazol-4(5H)-one as New Inhibitors of Protein Kinase DYRK1A.
Pharmaceuticals (Basel)
; 14(11)2021 Oct 27.
Artigo
Inglês
| MEDLINE | ID: mdl-34832868
7.
Electron Transfer Kinetics in a Deep Eutectic Solvent.
J Phys Chem B
; 124(6): 1025-1032, 2020 Feb 13.
Artigo
Inglês
| MEDLINE | ID: mdl-31972091
8.
Inhibition of DYRK1A proteolysis modifies its kinase specificity and rescues Alzheimer phenotype in APP/PS1 mice.
Acta Neuropathol Commun
; 7(1): 46, 2019 03 18.
Artigo
Inglês
| MEDLINE | ID: mdl-30885273
9.
Correction of cognitive deficits in mouse models of Down syndrome by a pharmacological inhibitor of DYRK1A.
Dis Model Mech
; 11(9)2018 09 27.
Artigo
Inglês
| MEDLINE | ID: mdl-30115750
10.
Chemical synthesis and biological validation of immobilized protein kinase inhibitory Leucettines.
Eur J Med Chem
; 62: 728-37, 2013 Apr.
Artigo
Inglês
| MEDLINE | ID: mdl-23454515