Detalhe da pesquisa
1.
SPINT2 mutations in the Kunitz domain 2 found in SCSD patients inactivate HAI-2 as prostasin inhibitor via abnormal protein folding and N-glycosylation.
Hum Mol Genet
; 33(9): 752-767, 2024 Apr 18.
Artigo
Inglês
| MEDLINE | ID: mdl-38271183
2.
N-glycosylation on Asn-57 is required for the correct HAI-2 protein folding and protease inhibitory activity.
Glycobiology
; 33(3): 203-214, 2023 04 19.
Artigo
Inglês
| MEDLINE | ID: mdl-36637420
3.
Targeted HAI-2 deletion causes excessive proteolysis with prolonged active prostasin and depletion of HAI-1 monomer in intestinal but not epidermal epithelial cells.
Hum Mol Genet
; 30(19): 1833-1850, 2021 09 15.
Artigo
Inglês
| MEDLINE | ID: mdl-34089062
4.
Aberrant regulation favours matriptase proteolysis in neoplastic B-cells that co-express HAI-2.
J Enzyme Inhib Med Chem
; 34(1): 692-702, 2019 Dec.
Artigo
Inglês
| MEDLINE | ID: mdl-30777474
5.
Deregulated matriptase activity in oral squamous cell carcinoma promotes the infiltration of cancer-associated fibroblasts by paracrine activation of protease-activated receptor 2.
Int J Cancer
; 140(1): 130-141, 2017 Jan 01.
Artigo
Inglês
| MEDLINE | ID: mdl-27615543
6.
Matriptase activation and shedding through PDGF-D-mediated extracellular acidosis.
Am J Physiol Cell Physiol
; 310(4): C293-304, 2016 Feb 15.
Artigo
Inglês
| MEDLINE | ID: mdl-26157007
7.
Hepatocyte growth factor activator inhibitor type 1 maintains the assembly of keratin into desmosomes in keratinocytes by regulating protease-activated receptor 2-dependent p38 signaling.
Am J Pathol
; 185(6): 1610-23, 2015 Jun.
Artigo
Inglês
| MEDLINE | ID: mdl-25842366
8.
A matriptase-prostasin reciprocal zymogen activation complex with unique features: prostasin as a non-enzymatic co-factor for matriptase activation.
J Biol Chem
; 288(26): 19028-39, 2013 Jun 28.
Artigo
Inglês
| MEDLINE | ID: mdl-23673661
9.
Loss of hepatocyte growth factor activator inhibitor type 1 participates in metastatic spreading of human pancreatic cancer cells in a mouse orthotopic transplantation model.
Cancer Sci
; 105(1): 44-51, 2014 Jan.
Artigo
Inglês
| MEDLINE | ID: mdl-24147538
10.
Imbalanced matriptase pericellular proteolysis contributes to the pathogenesis of malignant B-cell lymphomas.
Am J Pathol
; 183(4): 1306-17, 2013 Oct.
Artigo
Inglês
| MEDLINE | ID: mdl-24070417
11.
Hepatocyte growth factor activator inhibitor-2 prevents shedding of matriptase.
Exp Cell Res
; 319(6): 918-29, 2013 Apr 01.
Artigo
Inglês
| MEDLINE | ID: mdl-23333561
12.
Loss of membrane-bound serine protease inhibitor HAI-1 induces oral squamous cell carcinoma cells' invasiveness.
J Pathol
; 228(2): 181-92, 2012 Oct.
Artigo
Inglês
| MEDLINE | ID: mdl-22262311
13.
Membrane-anchored serine protease matriptase regulates epithelial barrier formation and permeability in the intestine.
Proc Natl Acad Sci U S A
; 107(9): 4200-5, 2010 Mar 02.
Artigo
Inglês
| MEDLINE | ID: mdl-20142489
14.
HAI-1 is required for the novel role of FGFBP1 in maintenance of cell morphology and F-actin rearrangement in human keratinocytes.
Hum Cell
; 36(4): 1403-1415, 2023 Jul.
Artigo
Inglês
| MEDLINE | ID: mdl-37076641
15.
Mechanisms for the control of matriptase activity in the absence of sufficient HAI-1.
Am J Physiol Cell Physiol
; 302(2): C453-62, 2012 Jan 15.
Artigo
Inglês
| MEDLINE | ID: mdl-22031598
16.
Transport via the transcytotic pathway makes prostasin available as a substrate for matriptase.
J Biol Chem
; 286(7): 5793-802, 2011 Feb 18.
Artigo
Inglês
| MEDLINE | ID: mdl-21148558
17.
Antimetastatic activity isolated from Colocasia esculenta (taro).
Anticancer Drugs
; 23(2): 200-11, 2012 Feb.
Artigo
Inglês
| MEDLINE | ID: mdl-21934603
18.
Role of the polycystic kidney disease domain in matriptase chaperone activity and localization of hepatocyte growth factor activator inhibitor-1.
FEBS J
; 289(12): 3422-3439, 2022 06.
Artigo
Inglês
| MEDLINE | ID: mdl-35020274
19.
Differential subcellular distribution renders HAI-2 a less effective protease inhibitor than HAI-1 in the control of extracellular matriptase proteolytic activity.
Genes Dis
; 9(4): 1049-1061, 2022 Jul.
Artigo
Inglês
| MEDLINE | ID: mdl-35685459
20.
The difference in the intracellular Arg/Lys-rich and EHLVY motifs contributes to distinct subcellular distribution of HAI-1 versus HAI-2.
Hum Cell
; 35(1): 163-178, 2022 Jan.
Artigo
Inglês
| MEDLINE | ID: mdl-34643933