Detalhe da pesquisa
1.
Optimizing tuberculosis treatment efficacy: Comparing the standard regimen with Moxifloxacin-containing regimens.
PLoS Comput Biol
; 19(6): e1010823, 2023 06.
Artigo
Inglês
| MEDLINE | ID: mdl-37319311
2.
Optimizing Solid Tumor Treatment with Antibody-drug Conjugates Using Agent-Based Modeling: Considering the Role of a Carrier Dose and Payload Class.
Pharm Res
; 2024 May 28.
Artigo
Inglês
| MEDLINE | ID: mdl-38806889
3.
Simulating the Selection of Resistant Cells with Bystander Killing and Antibody Coadministration in Heterogeneous Human Epidermal Growth Factor Receptor 2-Positive Tumors.
Drug Metab Dispos
; 50(1): 8-16, 2022 01.
Artigo
Inglês
| MEDLINE | ID: mdl-34649966
4.
Computational modeling implicates protein scaffolding in p38 regulation of Akt.
J Theor Biol
; 555: 111294, 2022 12 21.
Artigo
Inglês
| MEDLINE | ID: mdl-36195198
5.
A virtual host model of Mycobacterium tuberculosis infection identifies early immune events as predictive of infection outcomes.
J Theor Biol
; 539: 111042, 2022 04 21.
Artigo
Inglês
| MEDLINE | ID: mdl-35114195
6.
Dynamic balance of pro- and anti-inflammatory signals controls disease and limits pathology.
Immunol Rev
; 285(1): 147-167, 2018 09.
Artigo
Inglês
| MEDLINE | ID: mdl-30129209
7.
A computational model tracks whole-lung Mycobacterium tuberculosis infection and predicts factors that inhibit dissemination.
PLoS Comput Biol
; 16(5): e1007280, 2020 05.
Artigo
Inglês
| MEDLINE | ID: mdl-32433646
8.
A Two-Pulse Cellular Stimulation Test Elucidates Variability and Mechanisms in Signaling Pathways.
Biophys J
; 116(5): 962-973, 2019 03 05.
Artigo
Inglês
| MEDLINE | ID: mdl-30782397
9.
Fluoroquinolone Efficacy against Tuberculosis Is Driven by Penetration into Lesions and Activity against Resident Bacterial Populations.
Antimicrob Agents Chemother
; 63(5)2019 05.
Artigo
Inglês
| MEDLINE | ID: mdl-30803965
10.
Data-Driven Model Validation Across Dimensions.
Bull Math Biol
; 81(6): 1853-1866, 2019 06.
Artigo
Inglês
| MEDLINE | ID: mdl-30830675
11.
Comparing efficacies of moxifloxacin, levofloxacin and gatifloxacin in tuberculosis granulomas using a multi-scale systems pharmacology approach.
PLoS Comput Biol
; 13(8): e1005650, 2017 Aug.
Artigo
Inglês
| MEDLINE | ID: mdl-28817561
12.
Identifying mechanisms driving formation of granuloma-associated fibrosis during Mycobacterium tuberculosis infection.
J Theor Biol
; 429: 1-17, 2017 09 21.
Artigo
Inglês
| MEDLINE | ID: mdl-28642013
13.
Computational and Empirical Studies Predict Mycobacterium tuberculosis-Specific T Cells as a Biomarker for Infection Outcome.
PLoS Comput Biol
; 12(4): e1004804, 2016 Apr.
Artigo
Inglês
| MEDLINE | ID: mdl-27065304
14.
Computational modeling predicts IL-10 control of lesion sterilization by balancing early host immunity-mediated antimicrobial responses with caseation during mycobacterium tuberculosis infection.
J Immunol
; 194(2): 664-77, 2015 Jan 15.
Artigo
Inglês
| MEDLINE | ID: mdl-25512604
15.
Multiscale Model of Mycobacterium tuberculosis Infection Maps Metabolite and Gene Perturbations to Granuloma Sterilization Predictions.
Infect Immun
; 84(5): 1650-1669, 2016 05.
Artigo
Inglês
| MEDLINE | ID: mdl-26975995
16.
Macrophage polarization drives granuloma outcome during Mycobacterium tuberculosis infection.
Infect Immun
; 83(1): 324-38, 2015 Jan.
Artigo
Inglês
| MEDLINE | ID: mdl-25368116
17.
A computational tool integrating host immunity with antibiotic dynamics to study tuberculosis treatment.
J Theor Biol
; 367: 166-179, 2015 Feb 21.
Artigo
Inglês
| MEDLINE | ID: mdl-25497475
18.
Identifying Mechanisms of Homeostatic Signaling in Fibroblast Differentiation.
Bull Math Biol
; 77(8): 1556-82, 2015 Aug.
Artigo
Inglês
| MEDLINE | ID: mdl-26384829
19.
In silico models of M. tuberculosis infection provide a route to new therapies.
Drug Discov Today Dis Models
; 15: 37-41, 2015.
Artigo
Inglês
| MEDLINE | ID: mdl-26904139
20.
Differential risk of tuberculosis reactivation among anti-TNF therapies is due to drug binding kinetics and permeability.
J Immunol
; 188(7): 3169-78, 2012 Apr 01.
Artigo
Inglês
| MEDLINE | ID: mdl-22379032