Detalhe da pesquisa
1.
Ring-fused 2-pyridones effective against multidrug-resistant Gram-positive pathogens and synergistic with standard-of-care antibiotics.
Proc Natl Acad Sci U S A
; 119(43): e2210912119, 2022 10 25.
Artigo
Inglês
| MEDLINE | ID: mdl-36252016
2.
THCz: Small molecules with antimicrobial activity that block cell wall lipid intermediates.
Proc Natl Acad Sci U S A
; 118(47)2021 11 23.
Artigo
Inglês
| MEDLINE | ID: mdl-34785593
3.
Chemical disarming of isoniazid resistance in Mycobacterium tuberculosis.
Proc Natl Acad Sci U S A
; 116(21): 10510-10517, 2019 05 21.
Artigo
Inglês
| MEDLINE | ID: mdl-31061116
4.
Intramolecular Povarov Reactions for the Synthesis of Chromenopyridine Fused 2-Pyridone Polyheterocycles Binding to α-Synuclein and Amyloid-ß Fibrils.
J Org Chem
; 85(21): 14174-14189, 2020 11 06.
Artigo
Inglês
| MEDLINE | ID: mdl-33099999
5.
N-acylated derivatives of sulfamethoxazole and sulfafurazole inhibit intracellular growth of Chlamydia trachomatis.
Antimicrob Agents Chemother
; 58(5): 2968-71, 2014 May.
Artigo
Inglês
| MEDLINE | ID: mdl-24566180
6.
The Bactericidal Fatty Acid Mimetic 2CCA-1 Selectively Targets Pneumococcal Extracellular Polyunsaturated Fatty Acid Metabolism.
mBio
; 11(6)2020 12 15.
Artigo
Inglês
| MEDLINE | ID: mdl-33323510
7.
Methyl sulfonamide substituents improve the pharmacokinetic properties of bicyclic 2-pyridone based Chlamydia trachomatis inhibitors.
Medchemcomm
; 10(11): 1966-1987, 2019 Nov 01.
Artigo
Inglês
| MEDLINE | ID: mdl-32206238
8.
Towards small molecule inhibitors of mono-ADP-ribosyltransferases.
Eur J Med Chem
; 95: 546-51, 2015 May 05.
Artigo
Inglês
| MEDLINE | ID: mdl-25847771
9.
Statistical molecular design: a tool to follow up hits from small-molecule screening.
Methods Mol Biol
; 1056: 169-88, 2014.
Artigo
Inglês
| MEDLINE | ID: mdl-24306873
10.
Chemical probes to study ADP-ribosylation: synthesis and biochemical evaluation of inhibitors of the human ADP-ribosyltransferase ARTD3/PARP3.
J Med Chem
; 56(23): 9556-68, 2013 Dec 12.
Artigo
Inglês
| MEDLINE | ID: mdl-24188023
11.
Modulation of curli assembly and pellicle biofilm formation by chemical and protein chaperones.
Chem Biol
; 20(10): 1245-54, 2013 Oct 24.
Artigo
Inglês
| MEDLINE | ID: mdl-24035282
12.
PARP inhibitor with selectivity toward ADP-ribosyltransferase ARTD3/PARP3.
ACS Chem Biol
; 8(8): 1698-703, 2013 Aug 16.
Artigo
Inglês
| MEDLINE | ID: mdl-23742272
13.
Design, synthesis and evaluation of triazole functionalized ring-fused 2-pyridones as antibacterial agents.
Eur J Med Chem
; 54: 637-46, 2012 Aug.
Artigo
Inglês
| MEDLINE | ID: mdl-22749393
14.
Discovery of ligands for ADP-ribosyltransferases via docking-based virtual screening.
J Med Chem
; 55(17): 7706-18, 2012 Sep 13.
Artigo
Inglês
| MEDLINE | ID: mdl-22823910