Detalhe da pesquisa
1.
Development of a Small Molecule Downmodulator for the Transcription Factor Brachyury.
Angew Chem Int Ed Engl
; 63(14): e202316496, 2024 Apr 02.
Artigo
Inglês
| MEDLINE | ID: mdl-38348945
2.
Unexpected specificity within dynamic transcriptional protein-protein complexes.
Proc Natl Acad Sci U S A
; 117(44): 27346-27353, 2020 11 03.
Artigo
Inglês
| MEDLINE | ID: mdl-33077600
3.
Conservation of coactivator engagement mechanism enables small-molecule allosteric modulators.
Proc Natl Acad Sci U S A
; 115(36): 8960-8965, 2018 09 04.
Artigo
Inglês
| MEDLINE | ID: mdl-30127017
4.
Flexible, symmetry-directed approach to assembling protein cages.
Proc Natl Acad Sci U S A
; 113(31): 8681-6, 2016 08 02.
Artigo
Inglês
| MEDLINE | ID: mdl-27432965
5.
Increased slow dynamics defines ligandability of BTB domains.
Nat Commun
; 13(1): 6989, 2022 11 16.
Artigo
Inglês
| MEDLINE | ID: mdl-36384931
6.
Development of potent dimeric inhibitors of GAS41 YEATS domain.
Cell Chem Biol
; 28(12): 1716-1727.e6, 2021 12 16.
Artigo
Inglês
| MEDLINE | ID: mdl-34289376
7.
Targeting epigenetic protein-protein interactions with small-molecule inhibitors.
Future Med Chem
; 12(14): 1305-1326, 2020 07.
Artigo
Inglês
| MEDLINE | ID: mdl-32551894
8.
Covalent and noncovalent constraints yield a figure eight-like conformation of a peptide inhibiting the menin-MLL interaction.
Eur J Med Chem
; 207: 112748, 2020 Dec 01.
Artigo
Inglês
| MEDLINE | ID: mdl-32882610
9.
Menin inhibitor MI-3454 induces remission in MLL1-rearranged and NPM1-mutated models of leukemia.
J Clin Invest
; 130(2): 981-997, 2020 02 03.
Artigo
Inglês
| MEDLINE | ID: mdl-31855575
10.
GAS41 Recognizes Diacetylated Histone H3 through a Bivalent Binding Mode.
ACS Chem Biol
; 13(9): 2739-2746, 2018 09 21.
Artigo
Inglês
| MEDLINE | ID: mdl-30071723
11.
Identification of Thiourea-Based Inhibitors of the B-Cell Lymphoma 6 BTB Domain via NMR-Based Fragment Screening and Computer-Aided Drug Design.
J Med Chem
; 61(17): 7573-7588, 2018 09 13.
Artigo
Inglês
| MEDLINE | ID: mdl-29969259
12.
Complexity of Blocking Bivalent Protein-Protein Interactions: Development of a Highly Potent Inhibitor of the Menin-Mixed-Lineage Leukemia Interaction.
J Med Chem
; 61(11): 4832-4850, 2018 06 14.
Artigo
Inglês
| MEDLINE | ID: mdl-29738674