Detalhe da pesquisa
1.
Interleukin-6 mediates PSAT1 expression and serine metabolism in TSC2-deficient cells.
Proc Natl Acad Sci U S A
; 118(39)2021 09 28.
Artigo
Inglês
| MEDLINE | ID: mdl-34544857
2.
PtdIns(3,4,5)P3-dependent Rac exchanger 1 (P-Rex1) promotes mammary tumor initiation and metastasis.
Proc Natl Acad Sci U S A
; 117(45): 28056-28067, 2020 11 10.
Artigo
Inglês
| MEDLINE | ID: mdl-33097662
3.
Protease activity sensors enable real-time treatment response monitoring in lymphangioleiomyomatosis.
Eur Respir J
; 59(4)2022 04.
Artigo
Inglês
| MEDLINE | ID: mdl-34561286
4.
TSC2 regulates microRNA biogenesis via mTORC1 and GSK3ß.
Hum Mol Genet
; 27(9): 1654-1663, 2018 05 01.
Artigo
Inglês
| MEDLINE | ID: mdl-29509898
5.
PtdIns(3,4,5)P3-dependent Rac Exchanger 1 (PREX1) Rac-Guanine Nucleotide Exchange Factor (GEF) Activity Promotes Breast Cancer Cell Proliferation and Tumor Growth via Activation of Extracellular Signal-regulated Kinase 1/2 (ERK1/2) Signaling.
J Biol Chem
; 291(33): 17258-70, 2016 08 12.
Artigo
Inglês
| MEDLINE | ID: mdl-27358402
6.
The Phosphatidylinositol (3,4,5)-Trisphosphate-dependent Rac Exchanger 1·Ras-related C3 Botulinum Toxin Substrate 1 (P-Rex1·Rac1) Complex Reveals the Basis of Rac1 Activation in Breast Cancer Cells.
J Biol Chem
; 290(34): 20827-20840, 2015 Aug 21.
Artigo
Inglês
| MEDLINE | ID: mdl-26112412
7.
Vitamin D binding protein: a new biomarker of disease severity in lymphangioleiomyomatosis.
Eur Respir J
; 52(5)2018 11.
Artigo
Inglês
| MEDLINE | ID: mdl-30385604
8.
mTORC1 upregulates B7-H3/CD276 to inhibit antitumor T cells and drive tumor immune evasion.
Nat Commun
; 14(1): 1214, 2023 03 03.
Artigo
Inglês
| MEDLINE | ID: mdl-36869048
9.
Bi-steric mTORC1 inhibitors induce apoptotic cell death in tumor models with hyperactivated mTORC1.
J Clin Invest
; 133(21)2023 11 01.
Artigo
Inglês
| MEDLINE | ID: mdl-37909334
10.
TSC2 regulates lysosome biogenesis via a non-canonical RAGC and TFEB-dependent mechanism.
Nat Commun
; 12(1): 4245, 2021 07 12.
Artigo
Inglês
| MEDLINE | ID: mdl-34253722
11.
MITF is a driver oncogene and potential therapeutic target in kidney angiomyolipoma tumors through transcriptional regulation of CYR61.
Oncogene
; 40(1): 112-126, 2021 01.
Artigo
Inglês
| MEDLINE | ID: mdl-33082558
12.
Immunotherapy for Lymphangioleiomyomatosis and Tuberous Sclerosis: Progress and Future Directions.
Chest
; 156(6): 1062-1067, 2019 12.
Artigo
Inglês
| MEDLINE | ID: mdl-31437431
13.
Rapamycin-upregulated miR-29b promotes mTORC1-hyperactive cell growth in TSC2-deficient cells by downregulating tumor suppressor retinoic acid receptor ß (RARß).
Oncogene
; 38(49): 7367-7383, 2019 12.
Artigo
Inglês
| MEDLINE | ID: mdl-31420607
14.
TSC2-deficient tumors have evidence of T cell exhaustion and respond to anti-PD-1/anti-CTLA-4 immunotherapy.
JCI Insight
; 3(8)2018 04 19.
Artigo
Inglês
| MEDLINE | ID: mdl-29669930
15.
Rapamycin-induced miR-21 promotes mitochondrial homeostasis and adaptation in mTORC1 activated cells.
Oncotarget
; 8(39): 64714-64727, 2017 Sep 12.
Artigo
Inglês
| MEDLINE | ID: mdl-29029388
16.
p62/SQSTM1 Cooperates with Hyperactive mTORC1 to Regulate Glutathione Production, Maintain Mitochondrial Integrity, and Promote Tumorigenesis.
Cancer Res
; 77(12): 3255-3267, 2017 06 15.
Artigo
Inglês
| MEDLINE | ID: mdl-28512249
17.
Correction: p62/SQSTM1 Cooperates with Hyperactive mTORC1 to Regulate Glutathione Production, Maintain Mitochondrial Integrity, and Promote Tumorigenesis.
Cancer Res
; 80(23): 5424, 2020 Dec 01.
Artigo
Inglês
| MEDLINE | ID: mdl-33268556
18.
INPP4A/INPP4B and P-Rex proteins: related but different?
Adv Biol Regul
; 52(1): 265-79, 2012 Jan.
Artigo
Inglês
| MEDLINE | ID: mdl-21925199