Detalhe da pesquisa
1.
An open-label, phase 1, randomized, three treatments, three-period, crossover, relative bioavailability study of CC-292, a potent and orally available inhibitor of bruton tyrosine kinase.
J Clin Pharm Ther
; 47(8): 1186-1193, 2022 Aug.
Artigo
Inglês
| MEDLINE | ID: mdl-35307850
2.
Evaluation of iberdomide and cytochrome p450 drug-drug interaction potential in vitro and in a phase 1 study in healthy subjects.
Eur J Clin Pharmacol
; 77(2): 223-231, 2021 Feb.
Artigo
Inglês
| MEDLINE | ID: mdl-32965548
3.
Cereblon modulator iberdomide induces degradation of the transcription factors Ikaros and Aiolos: immunomodulation in healthy volunteers and relevance to systemic lupus erythematosus.
Ann Rheum Dis
; 77(10): 1516-1523, 2018 10.
Artigo
Inglês
| MEDLINE | ID: mdl-29945920
4.
The effects of apremilast on the QTc interval in healthy male volunteers: a formal, thorough QT study.
Int J Clin Pharmacol Ther
; 54(8): 613-21, 2016 Aug.
Artigo
Inglês
| MEDLINE | ID: mdl-27285466
5.
A Phase I, Open-Label, Mass Balance Study of [14C]-Iberdomide in Healthy Subjects.
Eur J Drug Metab Pharmacokinet
; 49(3): 355-365, 2024 May.
Artigo
Inglês
| MEDLINE | ID: mdl-38521893
6.
Relative bioavailability of fedratinib through various alternative oral administration methods in healthy adults.
Cancer Chemother Pharmacol
; 93(4): 307-317, 2024 Apr.
Artigo
Inglês
| MEDLINE | ID: mdl-37955741
7.
Exposure-Response Analysis to Assess the Concentration-QTc Relationship of Iberdomide.
Clin Pharmacol Drug Dev
; 12(8): 819-825, 2023 08.
Artigo
Inglês
| MEDLINE | ID: mdl-37079714
8.
Model based assessment of food and acid reducing agent effects on oral absorption of mezigdomide (CC-92480), a novel cereblon E3 ligase modulator.
CPT Pharmacometrics Syst Pharmacol
; 12(10): 1473-1484, 2023 10.
Artigo
Inglês
| MEDLINE | ID: mdl-37705327
9.
Safety, Pharmacokinetics, and Antifibrotic Activity of CC-90001 (BMS-986360), a c-Jun N-Terminal Kinase Inhibitor, in Pulmonary Fibrosis.
Clin Pharmacol Drug Dev
; 12(8): 779-789, 2023 Aug.
Artigo
Inglês
| MEDLINE | ID: mdl-37378860
10.
An Open Label, Phase 1, Randomized, Seven-treatment, Seven-period, Crossover Study to Assess the Relative Bioavailability, pH Effect, Food Effect, and Dose Proportionality of CC-292, a Potent and Orally Available Bruton's Tyrosine Kinase Inhibitor.
Eur J Drug Metab Pharmacokinet
; 47(4): 579-592, 2022 Jul.
Artigo
Inglês
| MEDLINE | ID: mdl-35657581
11.
Effect of fluconazole on the pharmacokinetics of a single dose of fedratinib in healthy adults.
Cancer Chemother Pharmacol
; 90(4): 325-334, 2022 10.
Artigo
Inglês
| MEDLINE | ID: mdl-36001108
12.
Safety, Pharmacokinetics, and Pharmacodynamics of CC-90001 (BMS-986360), a c-Jun N-terminal Kinase Inhibitor, in Phase 1 Studies in Healthy Participants.
Clin Pharmacol Drug Dev
; 11(12): 1394-1404, 2022 12.
Artigo
Inglês
| MEDLINE | ID: mdl-36256505
13.
Pharmacokinetics and tolerability of apremilast in healthy Korean adult men.
Clin Transl Sci
; 14(4): 1505-1511, 2021 07.
Artigo
Inglês
| MEDLINE | ID: mdl-33932093
14.
First-in-Human, Single- and Multiple-Ascending-Dose Studies in Healthy Subjects to Assess Pharmacokinetics, Pharmacodynamics, and Safety/Tolerability of Iberdomide, a Novel Cereblon E3 Ligase Modulator.
Clin Pharmacol Drug Dev
; 10(5): 471-485, 2021 05.
Artigo
Inglês
| MEDLINE | ID: mdl-32969202
15.
Effects of strong and moderate CYP3A4 inducers on the pharmacokinetics of fedratinib in healthy adult participants.
Cancer Chemother Pharmacol
; 88(3): 369-377, 2021 09.
Artigo
Inglês
| MEDLINE | ID: mdl-34019108
16.
Impact of fedratinib on the pharmacokinetics of transporter probe substrates using a cocktail approach.
Cancer Chemother Pharmacol
; 88(6): 941-952, 2021 12.
Artigo
Inglês
| MEDLINE | ID: mdl-34477937
17.
Single-Dose Pharmacokinetics, Safety, and Tolerability of Avadomide (CC-122) in Subjects With Mild, Moderate, or Severe Renal Impairment.
Clin Pharmacol Drug Dev
; 9(7): 785-796, 2020 10.
Artigo
Inglês
| MEDLINE | ID: mdl-31891240
18.
Single-Dose Pharmacokinetics of Ozanimod and its Major Active Metabolites Alone and in Combination with Gemfibrozil, Itraconazole, or Rifampin in Healthy Subjects: A Randomized, Parallel-Group, Open-Label Study.
Adv Ther
; 37(10): 4381-4395, 2020 10.
Artigo
Inglês
| MEDLINE | ID: mdl-32857315
19.
An Open-Label, Phase 1 Study to Assess the Effects of Hepatic Impairment on Pomalidomide Pharmacokinetics.
Clin Pharmacol Drug Dev
; 8(3): 346-354, 2019 04.
Artigo
Inglês
| MEDLINE | ID: mdl-29746728
20.
Drug-Drug Interaction Study to Assess the Effect of Cytochrome P450 Inhibition and Induction on the Pharmacokinetics of the Novel Cereblon Modulator Avadomide (CC-122) in Healthy Adult Subjects.
J Clin Pharmacol
; 59(12): 1620-1631, 2019 12.
Artigo
Inglês
| MEDLINE | ID: mdl-31172535