1.
Bioorg Med Chem
; 24(7): 1480-7, 2016 Apr 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-26906473
RESUMO
A flexible and efficient synthesis of the neuroprotective alkaloid, dictyoquinazol A, is reported. Several structural analogues of the target molecule were produced, and the neuroprotective activity of this series of compounds was investigated using three different cell-based models of stroke. Several of the new compounds were found to have superior activity compared to the natural product. This work has established a new molecular scaffold that holds promise for a novel pharmaceutical treatment for stroke.