Wound infiltration with local anaesthetic agents for laparoscopic cholecystectomy.

BACKGROUND: While laparoscopic cholecystectomy is generally considered to be less painful than open surgery, pain is one of the important reasons for delayed discharge after day surgery resulting in overnight stay following laparoscopic cholecystectomy. The safety and effectiveness of local anaesthetic wound infiltration in people undergoing laparoscopic cholecystectomy is not known. OBJECTIVES: To assess the benefits and harms of local anaesthetic wound infiltration in patients undergoing laparoscopic cholecystectomy and to identify the best method of local anaesthetic wound infiltration with regards to the type of local anaesthetic, dosage, and time of administration of the local anaesthetic. SEARCH METHODS: We searched the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, EMBASE, and Science Citation Index Expanded until February 2013 to identify studies of relevance to this review. We included randomised clinical trials for benefit and quasi-randomised and comparative non-randomised studies for treatment-related harms. SELECTION CRITERIA: Only randomised clinical trials (irrespective of language, blinding, or publication status) comparing local anaesthetic wound infiltration versus placebo, no intervention, or inactive control during laparoscopic cholecystectomy, trials comparing different local anaesthetic agents for local anaesthetic wound infiltration, and trials comparing the different times of local anaesthetic wound infiltration were considered for the review. DATA COLLECTION AND ANALYSIS: Two review authors collected the data independently. We analysed the data with both fixed-effect and random-effects meta-analysis models using RevMan. For each outcome, we calculated the risk ratio (RR) or mean difference (MD) with 95% confidence interval (CI). MAIN RESULTS: Twenty-six trials fulfilled the inclusion criteria of the review. All the 26 trials except one trial of 30 participants were at high risk of bias. Nineteen of the trials with 1263 randomised participants provided data for this review. Ten of the 19 trials compared local anaesthetic wound infiltration versus inactive control. One of the 19 trials compared local anaesthetic wound infiltration with two inactive controls, normal saline and no intervention. Two of the 19 trials had four arms comparing local anaesthetic wound infiltration with inactive controls in the presence and absence of co-interventions to decrease pain after laparoscopic cholecystectomy. Four of the 19 trials had three or more arms that could be included for the comparison of local anaesthetic wound infiltration versus inactive control and different methods of local anaesthetic wound infiltration. The remaining two trials compared different methods of local anaesthetic wound infiltration.Most trials included only low anaesthetic risk people undergoing elective laparoscopic cholecystectomy. Seventeen trials randomised a total of 1095 participants to local anaesthetic wound infiltration (587 participants) versus no local anaesthetic wound infiltration (508 participants). Various anaesthetic agents were used but bupivacaine was the commonest local anaesthetic used. There was no mortality in either group in the seven trials that reported mortality (0/280 (0%) in local anaesthetic infiltration group versus 0/259 (0%) in control group). The effect of local anaesthetic on the proportion of people who developed serious adverse events was imprecise and compatible with increase or no difference in serious adverse events (seven trials; 539 participants; 2/280 (0.8%) in local anaesthetic group versus 1/259 (0.4%) in control; RR 2.00; 95% CI 0.19 to 21.59; very low quality evidence). None of the serious adverse events were related to local anaesthetic wound infiltration. None of the trials reported patient quality of life. The proportion of participants who were discharged as day surgery patients was higher in the local anaesthetic infiltration group than in the no local anaesthetic infiltration group (one trial; 97 participants; 33/50 (66.0%) in the local anaesthetic group versus 20/47 (42.6%) in the control group; RR 1.55; 95% CI 1.05 to 2.28; very low quality evidence). The effect of local anaesthetic on the length of hospital stay was compatible with a decrease, increase, or no difference in the length of hospital stay between the two groups (four trials; 327 participants; MD -0.26 days; 95% CI -0.67 to 0.16; very low quality evidence). The pain scores as measured by the visual analogue scale (0 to 10 cm) were lower in the local anaesthetic infiltration group than the control group at 4 to 8 hours (13 trials; 806 participants; MD -1.33 cm on the VAS; 95% CI -1.54 to -1.12; very low quality evidence) and 9 to 24 hours (12 trials; 756 participants; MD -0.36 cm on the VAS; 95% CI -0.53 to -0.20; very low quality evidence). The effect of local anaesthetic on the time taken to return to normal activity between the two groups was imprecise and compatible with a decrease, increase, or no difference in the time taken to return to normal activity (two trials; 195 participants; MD 0.14 days; 95% CI -0.59 to 0.87; very low quality evidence). None of the trials reported on return to work.Four trials randomised a total of 149 participants to local anaesthetic wound infiltration prior to skin incision (74 participants) versus local anaesthetic wound infiltration at the end of surgery (75 participants). Two trials randomised a total of 176 participants to four different local anaesthetics (bupivacaine, levobupivacaine, ropivacaine, neosaxitoxin). Although there were differences between the groups in some outcomes the changes were not consistent. There was no evidence to support the preference of one local anaesthetic over another or to prefer administration of local anaesthetic at a specific time compared with another. AUTHORS' CONCLUSIONS: Serious adverse events were rare in studies evaluating local anaesthetic wound infiltration (very low quality evidence). There is very low quality evidence that infiltration reduces pain in low anaesthetic risk people undergoing elective laparoscopic cholecystectomy. However, the clinical importance of this reduction in pain is likely to be small. Further randomised clinical trials at low risk of systematic and random errors are necessary. Such trials should include important clinical outcomes such as quality of life and time to return to work in their assessment.

Pathology reporting of pelvic exenteration specimens for locally recurrent rectal cancer.

INTRODUCTION: Reporting of pelvic exenteration specimens for locally recurrent rectal cancer (LRRC) can be challenging for structured pathological analysis and currently, there is a lack of specific guidelines. The aim of this study was to assess the quality of pathology reporting in a cohort of patients who underwent pelvic exenteration for LRRC in a high-volume tertiary unit. MATERIALS AND METHODS: In a retrospective analysis of histopathology reports of consecutive patients who underwent pelvic exenteration for LRRC from 1996 to 2018, the quality of pathology reporting was assessed using the Structure Reporting Protocol for Colorectal Cancer. The primary endpoint was the completeness of pathology reporting, secondary endpoints were the association between the reporting style (narrative versus synoptic), reporting period (the first half versus the second half), as well as the activity of the pathologists with the completeness of pathology reporting. RESULTS: 221 patients who underwent pelvic exenteration for LRRC were included into the study. There was a high variability in completeness of pathology reporting within the cohort, ranging from 9.5% to 100%. Notably, microscopic clearance was reported in only 92.4% of the reports. Overall, a significantly higher rate of completeness was observed in synoptic reports when compared to narrative reports and in more recent compared to earlier reports. There was no significant association between the activity of pathologists and the completeness of reporting. CONCLUSIONS: This study shows a significant variability in the quality of reporting in pelvic exenteration for LRRC. The use of synoptic reporting clearly resulted in more complete reports.

Hiatal hernia repair with mesh: a survey of SAGES members.

BACKGROUND: Primary repair of large hiatal hernia is associated with a high recurrence rate. The use of mesh may reduce this recurrence rate. The indication for mesh use, the type of mesh to use, and the placement technique are controversial. A survey of surgeon practice was undertaken to obtain a better understanding of the controversies surrounding this clinical problem. METHODS: A questionnaire on the technique and results of mesh hiatal herniorrhaphy was sent to 1,192 members of the Society of Gastrointestinal and Endoscopic Surgeons (SAGES). RESULTS: There were 275 responses; 261 of these were analyzed. A total of 5,486 hiatal hernia repairs with mesh were reported; 77% and 23% were performed laparoscopically vs open, respectively. The most common indication for mesh usage was an increased size hiatal defect (46% of respondents). The most common mesh types were biomaterial (28%), polytetrafluoroethylene (25%), and polypropylene (21%). Suture anchorage was the most common fixation technique (56% of respondents). The findings showed a failure rate of 3%, a stricture rate of 0.2%, and an erosion rate of 0.3%. Biomaterial tended to be associated with failure, whereas nonabsorbable mesh tended to be associated with stricture and erosion. CONCLUSIONS: The use of mesh during hiatal hernia repair resulted in a reported recurrence rate which appeared to be lower than that obtained historically without mesh. No one mesh type was clearly superior in terms of avoiding failure and complication.

Simultaneous transurethral resection of bladder tumour and prostate: is it safe?

OBJECTIVES: This study aims to review and assess the safety of carrying out transurethral resection of prostate (TURP) and transurethral resection of bladder tumour (TURBT) simultaneously, in men who require TURP for bladder outflow obstruction and are incidentally found to have a transitional cell carcinoma of the bladder. METHODS: A detailed Medline search between 1966 and 2005 identified only five published papers in the English literature addressing this subject. These were retrospective studies of small numbers and were analysed together in order to quantify the risk of bladder cancer recurrence that could be attributed to TURP. The anatomical area of interest for tumour recurrence was hence the bladder neck and prostatic urethra. RESULTS: 424 patients had simultaneous TURBT and TURP, whereas 350 had TURBT alone. The rate of recurrence of bladder tumour in these two groups of patients was 58 and 63%, respectively. The recurrence rate at the bladder neck and prostatic urethra was equally comparable. Tumour grade and multiplicity do not appear to influence the tumour recurrence rate when TURP is carried out at the same time as TURBT. CONCLUSIONS: There is paucity of clinical evidence to support the theoretical risk of tumour cell implantation at the bladder neck and prostatic urethra when TURP is carried out at the time of TURBT.

Laparoscopic management of a cystic artery pseudoaneurysm in a patient with calculus cholecystitis.

INTRODUCTION: Pseudoaneurysm of the cystic artery is very rare. In the majority of cases it has been reported as a post-operative complication of laparoscopic cholecystectomy, however it has also been associated with the presence of acute cholecystitis or pancreatitis. When these pseudoaneurysms rupture they can lead to intraperitoneal bleeding, haemobilia and upper gastrointestinal haemorrhage. Radiological as well as open surgical approaches have been described for control of this rare pathology. PRESENTATION OF CASE: We report the laparoscopic surgical management of an incidental, unruptured cystic artery pseudoaneurysm in a patient presenting with acute cholecystitis. DISCUSSION: Cystic artery pseudoaneurysm is a rare entity and as such there is no consensus on the clinical management of this condition. A variety of treatment strategies have been reported in the literature including radiological selective embolisation and coiling, open cholecystectomy with ligation of the aneurysm, or a two-step approach involving radiological management of the pseudoaneurysm followed by an elective cholecystectomy. CONCLUSION: In this report we have demonstrated that laparoscopic management of a cystic artery pseudoaneurysm with simultaneous laparoscopic cholecystectomy is feasible and safe. This avoids multiple invasive procedures and decreases morbidity associated with open surgery.

Laparoscopic management of Bouveret syndrome.

Bouveret syndrome is a proximal form of gallstone ileus where a large gallstone lodges in the pylorus or proximal duodenum, having passed through a bilioenteric fistula that has formed secondary to previous cholecystitis. We describe the laparoscopic extraction of a giant 'Bouveret' gallstone from the duodenum of an elderly man with morbid obesity.

UK foundation-year 1 doctors--a survey uncovering infrequent theater experience regardless of time, place, or surgical specialty.

INTRODUCTION: Doctors in the United Kingdom are expected to choose a broad career path after approximately 16 months of finishing medical school. We aim to investigate how much surgical exposure foundation-year (FY)1 doctors would have by the end of their first year after finishing medical school and whether this is sufficient to make an informed decision on a career in surgery. METHOD: Cross-sectional survey via a 10-part questionnaire sent to 1341 FY1 doctors at the end of their first clinical year across secondary and tertiary hospitals within 9 foundation schools in the United Kingdom. RESULTS: A total of 389 FY1 doctors responded. More than half (52.2%) of the FY1 doctors were unable to attend theater more than 5 times during their rotation. Length of surgical rotation, surgical specialty, type of hospital, and prior interest in surgery had no significant effect on theater attendance (p > 0.05). More than half (50.9%) of the FY1 doctors did not feel like they had had sufficient experience to make an informed decision about a career in surgery. DISCUSSION: Poor theater attendance is common among FY1 doctors, which may lead to ill-informed specialty career decisions. The Modernising Medical Careers program and European Working Time Directive are likely contributing to this lack of exposure. Protected and logged theater sessions for all FY1 doctors could ensure sufficient exposure. New initiatives need to be employed to increase surgical exposure among FY1 doctors to ensure that specialty choices in their second FY are informed ones. The proposed changes to the United Kingdom's junior doctor's training in the "Shape of Training" report may mean that changes in exposure in the early years are even more pertinent.

Improved patient education facilitates adherence to preoperative fasting guidelines.

Preoperative fasting is recognised as an important factor in perioperative patient care. Implementation of guidelines on preoperative fasting remains sub-optimal. We audited perioperative fasting in a district general hospital, implemented changes to the preoperative information leaflet and improved fasting practices. The manner in which information is presented to patients impacts behavior and adherence to recommendations. Improving this domain of clinical practice requires thorough and conscious effort and repeated reassessment.

Coronary artery disease and HIV; getting to the HAART of the matter.

Premature coronary disease is an important emerging paradigm affecting contemporary HIV patients. Through immune reconstruction HIV causes multisystem pathology. Recent advances in the treatment of AIDS, mainly highly active retroviral therapy (HAART), have transformed this previously terminal illness to a chronic disease. However, an interplay between traditional risk factors in a high risk predominantly male population together with the effect of the long term use of HAART in inducing a metabolic syndrome is leading to a premature and aggressive coronary artery disease phenotype not previously recognised. An association between HAART and increased cardiovascular events appears to exist. However, currently this risk appears to be low, and HAART is vital to maintain adequate viral suppression and disease control. HAART- and viral-associated dyslipidaemia can pose a significant challenge to the clinician as drug interactions may precipitate drug toxicity. In our institution a varied phenotypic pattern of coronary disease is seen angiographically from severe atherosclerotic calcific disease through to aneurysm formation and thrombotic occlusion. This is illustrated by case studies. There is a need for aggressive primary and secondary prevention strategies in this important sub-group of patients with a multi-disciplinary approach required in the management including cardiologists, metabolic physicians and lipidologists.

Evaluation of patient's understanding and recall of the consent process after open inguinal hernia repairs.

INTRODUCTION: Open inguinal Hernia repair is one of the most commonly performed operative procedure. Despite this, hernia repair can cause considerable morbidity and rarely mortality. Some of these complications such as chronic pain and testicular complications can be easily disregarded, thereby leading to medico-legal claims being made. As a result, the quality of consent process is crucial in increasing patient satisfaction after inguinal hernia repair. This is a prospective study exploring patient's recall of the consenting practice after elective open inguinal hernia repairs at our institute. METHODS: Patients who had an elective, Lichtenstein inguinal hernia repair between January to October 2009 were identified. Patients were contacted by telephone after 3 days and a questionnaire was completed. RESULTS: There were 86 patients included in our study. The male:female ratio was 70:16 whilst the average age was 63.2+/-19.2 years. 42 patients stated pain relief as the main indication for having the operation whilst 30 patients feared incarceration or strangulation as the main indication. Infection was the complication recalled most by patients in our study (31 patients), followed by bleeding (30 patients). Only 2 patients were aware of developing potential chronic pain and 10 patients realised the potential for testicular problems. 57 patients were aware of having a mesh inside their groin. There were 61 patients who were aware of laparoscopic approach as an alternative to open inguinal hernia repair. CONCLUSIONS: Recall of consent is very poor. As a result, repeating the information stated and providing additional resource may reinforce the consent process.

Chaperone policy in accident and emergency departments: a national survey.

BACKGROUND: Medico-legal societies and the General Medical Council have been urging a greater use of chaperones during intimate examinations. However, research into the use of chaperones has been limited only to general practice. The objectives of this national survey were to find out: (1) whether formal chaperone policy exists in accident and emergency (A&E) departments; (2) the frequency of chaperone use; and (3) clinical applications. METHODS: A simple questionnaire was submitted to the lead clinicians/clinical directors of 460 A&E departments in the UK. The departments were identified through the British Association of Accident and Emergency Medicine Directory. The completed questionnaires were either posted or faxed back to our department. RESULTS: In total, 270 of 460 forms were returned (58.7%), of which only 246 were useable. Although 81.71% of A&E lead clinicians/clinical directors believe that formal policies are needed, only 3.65% of the departments have a formal policy. The highest percentage of chaperone use was observed for male doctors examining female patients (91.46%), while the lowest percentage was observed for male doctors examining male patients (7.32%). Worryingly, 25.61% reported incidents of complaints regarding inappropriate examination by doctors. CONCLUSION: We have demonstrated deficiencies in chaperone use and have identified specific factors that render A&E departments particularly vulnerable to allegations of inappropriate practice. We believe that policies should be designed and implemented focusing on the specific needs of A&E departments to counteract the rising numbers of medico-legal cases, thus safeguarding patient care and protecting the health providers.

Gynefix tales: cervical perforation and repeated late expulsion with the Gynefix device.

We describe two unusual cases; both patients wish to continue using the Gynefix despite experiencing difficulty with the device. In case A, the marker string of the Gynefix(R) perforated the full thickness of the cervix and was visualized on the left lateral aspect of the cervix. Three months later the string had moved again and could no longer be visualized, but an ultrasound scan confirmed fundal implantation of the device. Case B demonstrates repeated late expulsion and failure of implantation of Gynefix. Appropriateness of ultrasound with reference to measurement of the distance SS (between the peritoneal surface of the uterine fundus and the first copper sleeve of the Gynefix), failure of implantation and problems with the new Gynefix introducer are discussed.