Detalhe da pesquisa
1.
A first-in-human, open-label Phase 1b and a randomised, double-blind Phase 2a clinical trial in recent-onset type 1 diabetes with AG019 as monotherapy and in combination with teplizumab.
Diabetologia
; 67(1): 27-41, 2024 Jan.
Artigo
Inglês
| MEDLINE | ID: mdl-37782353
2.
Impact on in-depth immunophenotyping of delay to peripheral blood processing.
Clin Exp Immunol
; 2024 May 02.
Artigo
Inglês
| MEDLINE | ID: mdl-38693758
3.
High proinsulin:C-peptide ratio identifies individuals with stage 2 type 1 diabetes at high risk for progression to clinical diagnosis and responses to teplizumab treatment.
Diabetologia
; 66(12): 2283-2291, 2023 12.
Artigo
Inglês
| MEDLINE | ID: mdl-37667106
4.
Th2 cell clonal expansion at diagnosis in human type 1 diabetes.
Clin Immunol
; 257: 109829, 2023 12.
Artigo
Inglês
| MEDLINE | ID: mdl-37907122
5.
Guidelines for standardizing T-cell cytometry assays to link biomarkers, mechanisms, and disease outcomes in type 1 diabetes.
Eur J Immunol
; 52(3): 372-388, 2022 03.
Artigo
Inglês
| MEDLINE | ID: mdl-35025103
6.
Chemokines, soluble PD-L1, and immune cell hyporesponsiveness are distinct features of SARS-CoV-2 critical illness.
Am J Physiol Lung Cell Mol Physiol
; 323(1): L14-L26, 2022 07 01.
Artigo
Inglês
| MEDLINE | ID: mdl-35608267
7.
An Anti-CD3 Antibody, Teplizumab, in Relatives at Risk for Type 1 Diabetes.
N Engl J Med
; 381(7): 603-613, 2019 08 15.
Artigo
Inglês
| MEDLINE | ID: mdl-31180194
8.
Single Nucleotide Variant in FAS Associates With Organ Failure and Soluble Fas Cell Surface Death Receptor in Critical Illness.
Crit Care Med
; 50(3): e284-e293, 2022 03 01.
Artigo
Inglês
| MEDLINE | ID: mdl-34593707
9.
Clinical and experimental treatment of type 1 diabetes.
Clin Exp Immunol
; 210(2): 105-113, 2022 12 15.
Artigo
Inglês
| MEDLINE | ID: mdl-35980300
10.
A simple strategy for sample annotation error detection in cytometry datasets.
Cytometry A
; 101(4): 351-360, 2022 04.
Artigo
Inglês
| MEDLINE | ID: mdl-34967113
11.
Weekly injection of IL-2 using an injectable hydrogel reduces autoimmune diabetes incidence in NOD mice.
Diabetologia
; 64(1): 152-158, 2021 01.
Artigo
Inglês
| MEDLINE | ID: mdl-33125521
12.
Efficient CRISPR/Cas9 Disruption of Autoimmune-Associated Genes Reveals Key Signaling Programs in Primary Human T Cells.
J Immunol
; 203(12): 3166-3178, 2019 12 15.
Artigo
Inglês
| MEDLINE | ID: mdl-31722988
13.
Treatment of type 1 diabetes with teplizumab: clinical and immunological follow-up after 7 years from diagnosis.
Diabetologia
; 62(4): 655-664, 2019 04.
Artigo
Inglês
| MEDLINE | ID: mdl-30569273
14.
Circulating integrin alpha4/beta7+ lymphocytes targeted by vedolizumab have a pro-inflammatory phenotype.
Clin Immunol
; 193: 24-32, 2018 08.
Artigo
Inglês
| MEDLINE | ID: mdl-29842945
15.
Attenuated IL-2R signaling in CD4 memory T cells of T1D subjects is intrinsic and dependent on activation state.
Clin Immunol
; 181: 67-74, 2017 08.
Artigo
Inglês
| MEDLINE | ID: mdl-28645874
16.
Remodeling T cell compartments during anti-CD3 immunotherapy of type 1 diabetes.
Cell Immunol
; 319: 3-9, 2017 Sep.
Artigo
Inglês
| MEDLINE | ID: mdl-28844471
17.
Low-dose interleukin-2 fosters a dose-dependent regulatory T cell tuned milieu in T1D patients.
J Autoimmun
; 58: 48-58, 2015 Apr.
Artigo
Inglês
| MEDLINE | ID: mdl-25634360
18.
Renegade homeostatic cytokine responses in T1D: drivers of regulatory/effector T cell imbalance.
Clin Immunol
; 151(2): 146-54, 2014 Apr.
Artigo
Inglês
| MEDLINE | ID: mdl-24576418
19.
ECM components guide IL-10 producing regulatory T-cell (TR1) induction from effector memory T-cell precursors.
Proc Natl Acad Sci U S A
; 108(19): 7938-43, 2011 May 10.
Artigo
Inglês
| MEDLINE | ID: mdl-21518860
20.
Integrating Omics into Functional Biomarkers of Type 1 Diabetes.
Cold Spring Harb Perspect Med
; 2024 May 21.
Artigo
Inglês
| MEDLINE | ID: mdl-38772709