1.
Nucleosides Nucleotides Nucleic Acids
; 20(4-7): 1067-78, 2001.
Artigo
em Inglês
| MEDLINE
| ID: mdl-11562960
RESUMO
Cyclin-dependent kinases (CDKs) belong to a class of enzymes that control the ability of a cell to enter into and proceed through the cell division cycle. Using purine as a scaffold, we have synthesized a number of nanomolar inhibitors of CDK-2/cyclin E. In this report, the synthesis of a series of piperidine-substituted purine analogs will be presented, as well as some of their in vitro and in vivo biological effects.