Detalhe da pesquisa
1.
Na+ controls hypoxic signalling by the mitochondrial respiratory chain.
Nature
; 586(7828): 287-291, 2020 10.
Artigo
Inglês
| MEDLINE | ID: mdl-32728214
2.
Innovative pathological network-based multitarget approaches for Alzheimer's disease treatment.
Med Res Rev
; 2024 Apr 28.
Artigo
Inglês
| MEDLINE | ID: mdl-38678582
3.
KEAP1-NRF2 protein-protein interaction inhibitors: Design, pharmacological properties and therapeutic potential.
Med Res Rev
; 43(1): 237-287, 2023 01.
Artigo
Inglês
| MEDLINE | ID: mdl-36086898
4.
From single drug targets to synergistic network pharmacology in ischemic stroke.
Proc Natl Acad Sci U S A
; 116(14): 7129-7136, 2019 04 02.
Artigo
Inglês
| MEDLINE | ID: mdl-30894481
5.
Transcription Factor NRF2 as a Therapeutic Target for Chronic Diseases: A Systems Medicine Approach.
Pharmacol Rev
; 70(2): 348-383, 2018 04.
Artigo
Inglês
| MEDLINE | ID: mdl-29507103
6.
Central Activation of Alpha7 Nicotinic Signaling Attenuates LPS-Induced Neuroinflammation and Sickness Behavior in Adult but Not in Aged Animals.
Molecules
; 26(8)2021 Apr 07.
Artigo
Inglês
| MEDLINE | ID: mdl-33916910
7.
Melatonin-sulforaphane hybrid ITH12674 attenuates glial response in vivo by blocking LPS binding to MD2 and receptor oligomerization.
Pharmacol Res
; 152: 104597, 2020 02.
Artigo
Inglês
| MEDLINE | ID: mdl-31838078
8.
NOX4-dependent neuronal autotoxicity and BBB breakdown explain the superior sensitivity of the brain to ischemic damage.
Proc Natl Acad Sci U S A
; 114(46): 12315-12320, 2017 11 14.
Artigo
Inglês
| MEDLINE | ID: mdl-29087944
9.
Protective Effects of Ursolic Acid Against Cytotoxicity Induced by Corticosterone: Role of Protein Kinases.
Neurochem Res
; 2019 Nov 11.
Artigo
Inglês
| MEDLINE | ID: mdl-31713091
10.
Pharmacological doses of melatonin impede cognitive decline in tau-related Alzheimer models, once tauopathy is initiated, by restoring the autophagic flux.
J Pineal Res
; 67(1): e12578, 2019 Aug.
Artigo
Inglês
| MEDLINE | ID: mdl-30943316
11.
Chromaffin cells as a model to evaluate mechanisms of cell death and neuroprotective compounds.
Pflugers Arch
; 470(1): 187-198, 2018 01.
Artigo
Inglês
| MEDLINE | ID: mdl-28823085
12.
The APPswe/PS1A246E mutations in an astrocytic cell line leads to increased vulnerability to oxygen and glucose deprivation, Ca2+ dysregulation, and mitochondrial abnormalities.
J Neurochem
; 145(2): 170-182, 2018 04.
Artigo
Inglês
| MEDLINE | ID: mdl-29315575
13.
Positive allosteric modulation of alpha-7 nicotinic receptors promotes cell death by inducing Ca(2+) release from the endoplasmic reticulum.
J Neurochem
; 133(3): 309-19, 2015 May.
Artigo
Inglês
| MEDLINE | ID: mdl-25650007
14.
The modulation of NMDA receptors and L-arginine/nitric oxide pathway is implicated in the anti-immobility effect of creatine in the tail suspension test.
Amino Acids
; 47(4): 795-811, 2015 Apr.
Artigo
Inglês
| MEDLINE | ID: mdl-25555469
15.
Inhibition of calpain-regulated p35/cdk5 plays a central role in sildenafil-induced protection against chemical hypoxia produced by malonate.
Biochim Biophys Acta
; 1832(6): 705-17, 2013 Jun.
Artigo
Inglês
| MEDLINE | ID: mdl-23415811
16.
Neuroprotective effect of melatonin against ischemia is partially mediated by alpha-7 nicotinic receptor modulation and HO-1 overexpression.
J Pineal Res
; 56(2): 204-12, 2014 Mar.
Artigo
Inglês
| MEDLINE | ID: mdl-24350834
17.
Adipose tissue as a therapeutic target for vascular damage in Alzheimer's disease.
Br J Pharmacol
; 181(6): 840-878, 2024 03.
Artigo
Inglês
| MEDLINE | ID: mdl-37706346
18.
Guanosine controls inflammatory pathways to afford neuroprotection of hippocampal slices under oxygen and glucose deprivation conditions.
J Neurochem
; 126(4): 437-50, 2013 Aug.
Artigo
Inglês
| MEDLINE | ID: mdl-23713463
19.
Cytotoxicity Models in Chromaffin Cells to Evaluate Neuroprotective Compounds.
Methods Mol Biol
; 2565: 361-370, 2023.
Artigo
Inglês
| MEDLINE | ID: mdl-36205906
20.
Small Synthetic Hyaluronan Disaccharide BIS014 Mitigates Neuropathic Pain in Mice.
J Pain
; 24(1): 68-83, 2023 01.
Artigo
Inglês
| MEDLINE | ID: mdl-36087908