Pesquisa | Secretaria de Estado da Saúde

1.

Regulatory T Cells Restrain Interleukin-2- and Blimp-1-Dependent Acquisition of Cytotoxic Function by CD4⁺ T Cells.

Sledzinska, Anna; Vila de Mucha, Maria; Bergerhoff, Katharina; Hotblack, Alastair; Demane, Dafne Franz; Ghorani, Ehsan; Akarca, Ayse U; Marzolini, Maria A V; Solomon, Isabelle; Vargas, Frederick Arce; Pule, Martin; Ono, Masahiro; Seddon, Benedict; Kassiotis, George; Ariyan, Charlotte E; Korn, Thomas; Marafioti, Teresa; Lord, Graham M; Stauss, Hans; Jenner, Richard G; Peggs, Karl S; Quezada, Sergio A.

Immunity ; 52(1): 151-166.e6, 2020 01 14.

Artigo Inglês | MEDLINE | ID: mdl-31924474

2.

Role and species-specific expression of colon T cell homing receptor GPR15 in colitis.

Nguyen, Linh P; Pan, Junliang; Dinh, Theresa Thanh; Hadeiba, Husein; O'Hara, Edward; Ebtikar, Ahmad; Hertweck, Arnulf; Gökmen, M Refik; Lord, Graham M; Jenner, Richard G; Butcher, Eugene C; Habtezion, Aida.

Nat Immunol ; 16(2): 207-213, 2015 Feb.

Artigo Inglês | MEDLINE | ID: mdl-25531831

3.

Transcription factor-driven regulation of ILC1 and ILC3.

Schroeder, Jan-Hendrik; Howard, Jane K; Lord, Graham M.

Trends Immunol ; 43(7): 564-579, 2022 07.

Artigo Inglês | MEDLINE | ID: mdl-35618586

4.

Retinoic acid is essential for Th1 cell lineage stability and prevents transition to a Th17 cell program.

Brown, Chrysothemis C; Esterhazy, Daria; Sarde, Aurelien; London, Mariya; Pullabhatla, Venu; Osma-Garcia, Ines; Al-Bader, Raya; Ortiz, Carla; Elgueta, Raul; Arno, Matthew; de Rinaldis, Emanuele; Mucida, Daniel; Lord, Graham M; Noelle, Randolph J.

Immunity ; 42(3): 499-511, 2015 Mar 17.

Artigo Inglês | MEDLINE | ID: mdl-25769610

5.

The TH1 cell lineage-determining transcription factor T-bet suppresses TH2 gene expression by redistributing GATA3 away from TH2 genes.

Hertweck, Arnulf; Vila de Mucha, Maria; Barber, Paul R; Dagil, Robert; Porter, Hayley; Ramos, Andres; Lord, Graham M; Jenner, Richard G.

Nucleic Acids Res ; 50(8): 4557-4573, 2022 05 06.

Artigo Inglês | MEDLINE | ID: mdl-35438764

6.

A population of naive-like CD4⁺ T cells stably polarized to the T_H 1 lineage.

Lo, Jonathan W; de Mucha, Maria Vila; Henderson, Stephen; Roberts, Luke B; Constable, Laura E; Garrido-Mesa, Natividad; Hertweck, Arnulf; Stolarczyk, Emilie; Houlder, Emma L; Jackson, Ian; MacDonald, Andrew S; Powell, Nick; Neves, Joana F; Howard, Jane K; Jenner, Richard G; Lord, Graham M.

Eur J Immunol ; 52(4): 566-581, 2022 04.

Artigo Inglês | MEDLINE | ID: mdl-35092032

7.

Monocyte migration profiles define disease severity in acute COVID-19 and unique features of long COVID.

Scott, Nicholas A; Pearmain, Laurence; Knight, Sean B; Brand, Oliver; Morgan, David J; Jagger, Christopher; Harbach, Sarah; Khan, Saba; Shuwa, Halima A; Franklin, Miriam; Kästele, Verena; Williams, Thomas; Prise, Ian; McClure, Flora A; Hackney, Pamela; Smith, Lara; Menon, Madhvi; Konkel, Joanne E; Lawless, Criag; Wilson, James; Mathioudakis, Alexander G; Stanel, Stefan C; Ustianowski, Andrew; Lindergard, Gabriella; Brij, Seema; Diar Bakerly, Nawar; Dark, Paul; Brightling, Christopher; Rivera-Ortega, Pilar; Lord, Graham M; Horsley, Alex; Piper Hanley, Karen; Felton, Timothy; Simpson, Angela; Grainger, John R; Hussell, Tracy; Mann, Elizabeth R.

Eur Respir J ; 61(5)2023 05.

Artigo Inglês | MEDLINE | ID: mdl-36922030

8.

MicroRNA-142 Critically Regulates Group 2 Innate Lymphoid Cell Homeostasis and Function.

Roberts, Luke B; Jowett, Geraldine M; Read, Emily; Zabinski, Tomas; Berkachy, Rita; Selkirk, Murray E; Jackson, Ian; Niazi, Umar; Anandagoda, Nelomi; Araki, Masatake; Araki, Kimi; Kasturiarachchi, Jagath; James, Chela; Enver, Tariq; Nimmo, Rachael; Reis, Rita; Howard, Jane K; Neves, Joana F; Lord, Graham M.

J Immunol ; 206(11): 2725-2739, 2021 06 01.

Artigo Inglês | MEDLINE | ID: mdl-34021046

9.

Mortality risk prediction of high-sensitivity C-reactive protein in suspected acute coronary syndrome: A cohort study.

Kaura, Amit; Hartley, Adam; Panoulas, Vasileios; Glampson, Ben; Shah, Anoop S V; Davies, Jim; Mulla, Abdulrahim; Woods, Kerrie; Omigie, Joe; Shah, Anoop D; Thursz, Mark R; Elliott, Paul; Hemmingway, Harry; Williams, Bryan; Asselbergs, Folkert W; O'Sullivan, Michael; Lord, Graham M; Trickey, Adam; Sterne, Jonathan Ac; Haskard, Dorian O; Melikian, Narbeh; Francis, Darrel P; Koenig, Wolfgang; Shah, Ajay M; Kharbanda, Rajesh; Perera, Divaka; Patel, Riyaz S; Channon, Keith M; Mayet, Jamil; Khamis, Ramzi.

PLoS Med ; 19(2): e1003911, 2022 02.

Artigo Inglês | MEDLINE | ID: mdl-35192610

10.

ILC1 drive intestinal epithelial and matrix remodelling.

Jowett, Geraldine M; Norman, Michael D A; Yu, Tracy T L; Rosell Arévalo, Patricia; Hoogland, Dominique; Lust, Suzette T; Read, Emily; Hamrud, Eva; Walters, Nick J; Niazi, Umar; Chung, Matthew Wai Heng; Marciano, Daniele; Omer, Omer S; Zabinski, Tomasz; Danovi, Davide; Lord, Graham M; Hilborn, Jöns; Evans, Nicholas D; Dreiss, Cécile A; Bozec, Laurent; Oommen, Oommen P; Lorenz, Christian D; da Silva, Ricardo M P; Neves, Joana F; Gentleman, Eileen.

Nat Mater ; 20(2): 250-259, 2021 02.

Artigo Inglês | MEDLINE | ID: mdl-32895507

11.

Exhausted CD4⁺ T Cells during Malaria Exhibit Reduced mTORc1 Activity Correlated with Loss of T-bet Expression.

Villegas-Mendez, Ana; Khandelwal, Garima; McGowan, Lucy M; Dookie, Rebecca S; Haley, Michael J; George, Charlotte; Sims, David; Lord, Graham M; Sinclair, Linda V; Jenner, Richard G; Couper, Kevin N.

J Immunol ; 205(6): 1608-1619, 2020 09 15.

Artigo Inglês | MEDLINE | ID: mdl-32817333

12.

Invasive versus non-invasive management of older patients with non-ST elevation myocardial infarction (SENIOR-NSTEMI): a cohort study based on routine clinical data.

Kaura, Amit; Sterne, Jonathan A C; Trickey, Adam; Abbott, Sam; Mulla, Abdulrahim; Glampson, Benjamin; Panoulas, Vasileios; Davies, Jim; Woods, Kerrie; Omigie, Joe; Shah, Anoop D; Channon, Keith M; Weber, Jonathan N; Thursz, Mark R; Elliott, Paul; Hemingway, Harry; Williams, Bryan; Asselbergs, Folkert W; O'Sullivan, Michael; Lord, Graham M; Melikian, Narbeh; Johnson, Thomas; Francis, Darrel P; Shah, Ajay M; Perera, Divaka; Kharbanda, Rajesh; Patel, Riyaz S; Mayet, Jamil.

Lancet ; 396(10251): 623-634, 2020 08 29.

Artigo Inglês | MEDLINE | ID: mdl-32861307

13.

The transcription factor T-bet regulates intestinal inflammation mediated by interleukin-7 receptor+ innate lymphoid cells.

Powell, Nick; Walker, Alan W; Stolarczyk, Emilie; Canavan, James B; Gökmen, M Refik; Marks, Ellen; Jackson, Ian; Hashim, Ahmed; Curtis, Michael A; Jenner, Richard G; Howard, Jane K; Parkhill, Julian; MacDonald, Thomas T; Lord, Graham M.

Immunity ; 37(4): 674-84, 2012 Oct 19.

Artigo Inglês | MEDLINE | ID: mdl-23063332

14.

Regulatory T-cell therapy in Crohn's disease: challenges and advances.

Clough, Jennie N; Omer, Omer S; Tasker, Scott; Lord, Graham M; Irving, Peter M.

Gut ; 69(5): 942-952, 2020 05.

Artigo Inglês | MEDLINE | ID: mdl-31980447

15.

Interleukin-22 orchestrates a pathological endoplasmic reticulum stress response transcriptional programme in colonic epithelial cells.

Powell, Nick; Pantazi, Eirini; Pavlidis, Polychronis; Tsakmaki, Anastasia; Li, Katherine; Yang, Feifei; Parker, Aimee; Pin, Carmen; Cozzetto, Domenico; Minns, Danielle; Stolarczyk, Emilie; Saveljeva, Svetlana; Mohamed, Rami; Lavender, Paul; Afzali, Behdad; Digby-Bell, Jonathan; Tjir-Li, Tsui; Kaser, Arthur; Friedman, Joshua; MacDonald, Thomas T; Bewick, Gavin A; Lord, Graham M.

Gut ; 69(3): 578-590, 2020 03.

Artigo Inglês | MEDLINE | ID: mdl-31792136

16.

Dominant regulation of long-term allograft survival is mediated by microRNA-142.

Anandagoda, Nelomi; Roberts, Luke B; Willis, Joanna C D; Sarathchandra, Padmini; Xiao, Fang; Jackson, Ian; Hertweck, Arnulf; Kapoor, Puja; Jenner, Richard G; Howard, Jane K; Lord, Graham M.

Am J Transplant ; 20(10): 2715-2727, 2020 10.

Artigo Inglês | MEDLINE | ID: mdl-32277570

17.

Correction of Defective T-Regulatory Cells From Patients With Crohn's Disease by Ex Vivo Ligation of Retinoic Acid Receptor-α.

Goldberg, Rimma; Scotta, Cristiano; Cooper, Dianne; Nissim-Eliraz, Einat; Nir, Eilam; Tasker, Scott; Irving, Peter M; Sanderson, Jeremy; Lavender, Paul; Ibrahim, Fowzia; Corcoran, Jonathan; Prevost, Toby; Shpigel, Nahum Y; Marelli-Berg, Federica; Lombardi, Giovanna; Lord, Graham M.

Gastroenterology ; 156(6): 1775-1787, 2019 05.

Artigo Inglês | MEDLINE | ID: mdl-30710527

18.

Genetic variants alter T-bet binding and gene expression in mucosal inflammatory disease.

Soderquest, Katrina; Hertweck, Arnulf; Giambartolomei, Claudia; Henderson, Stephen; Mohamed, Rami; Goldberg, Rimma; Perucha, Esperanza; Franke, Lude; Herrero, Javier; Plagnol, Vincent; Jenner, Richard G; Lord, Graham M.

PLoS Genet ; 13(2): e1006587, 2017 02.

Artigo Inglês | MEDLINE | ID: mdl-28187197

19.

The impact of donor and recipient common clinical and genetic variation on estimated glomerular filtration rate in a European renal transplant population.

Stapleton, Caragh P; Heinzel, Andreas; Guan, Weihua; van der Most, Peter J; van Setten, Jessica; Lord, Graham M; Keating, Brendan J; Israni, Ajay K; de Borst, Martin H; Bakker, Stephan J L; Snieder, Harold; Weale, Michael E; Delaney, Florence; Hernandez-Fuentes, Maria P; Reindl-Schwaighofer, Roman; Oberbauer, Rainer; Jacobson, Pamala A; Mark, Patrick B; Chapman, Fiona A; Phelan, Paul J; Kennedy, Claire; Sexton, Donal; Murray, Susan; Jardine, Alan; Traynor, Jamie P; McKnight, Amy Jayne; Maxwell, Alexander P; Smyth, Laura J; Oetting, William S; Matas, Arthur J; Mannon, Roslyn B; Schladt, David P; Iklé, David N; Cavalleri, Gianpiero L; Conlon, Peter J.

Am J Transplant ; 19(8): 2262-2273, 2019 08.

Artigo Inglês | MEDLINE | ID: mdl-30920136

20.

Reply.

Goldberg, Rimma; Lord, Graham M.

Gastroenterology ; 164(6): 1031-1032, 2023 May.

Artigo Inglês | MEDLINE | ID: mdl-31593699

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