Pesquisa | Secretaria de Estado da Saúde

1.

Broad neutralization of SARS-CoV-2 variants by an inhalable bispecific single-domain antibody.

Li, Cheng; Zhan, Wuqiang; Yang, Zhenlin; Tu, Chao; Hu, Gaowei; Zhang, Xiang; Song, Wenping; Du, Shujuan; Zhu, Yuanfei; Huang, Keke; Kong, Yu; Zhang, Meng; Mao, Qiyu; Gu, Xiaodan; Zhang, Yi; Xie, Youhua; Deng, Qiang; Song, Yuanlin; Chen, Zhenguo; Lu, Lu; Jiang, Shibo; Wu, Yanling; Sun, Lei; Ying, Tianlei.

Cell ; 185(8): 1389-1401.e18, 2022 04 14.

Artigo Inglês | MEDLINE | ID: mdl-35344711

2.

Antivirals with common targets against highly pathogenic viruses.

Lu, Lu; Su, Shan; Yang, Haitao; Jiang, Shibo.

Cell ; 184(6): 1604-1620, 2021 03 18.

Artigo Inglês | MEDLINE | ID: mdl-33740455

3.

Identification of Required Host Factors for SARS-CoV-2 Infection in Human Cells.

Daniloski, Zharko; Jordan, Tristan X; Wessels, Hans-Hermann; Hoagland, Daisy A; Kasela, Silva; Legut, Mateusz; Maniatis, Silas; Mimitou, Eleni P; Lu, Lu; Geller, Evan; Danziger, Oded; Rosenberg, Brad R; Phatnani, Hemali; Smibert, Peter; Lappalainen, Tuuli; tenOever, Benjamin R; Sanjana, Neville E.

Cell ; 184(1): 92-105.e16, 2021 01 07.

Artigo Inglês | MEDLINE | ID: mdl-33147445

4.

Androgen receptor-mediated CD8⁺ T cell stemness programs drive sex differences in antitumor immunity.

Yang, Chao; Jin, Jingsi; Yang, Yuanqin; Sun, Hongxiang; Wu, Lingling; Shen, Mingyi; Hong, Xiaochuan; Li, Wenwen; Lu, Lu; Cao, Dongqing; Wang, Xinran; Sun, Jing; Ye, Youqiong; Su, Bing; Deng, Liufu.

Immunity ; 55(7): 1268-1283.e9, 2022 07 12.

Artigo Inglês | MEDLINE | ID: mdl-35700739

5.

Inhibition of viral suppressor of RNAi proteins by designer peptides protects from enteroviral infection in vivo.

Fang, Yuan; Liu, Zezhong; Qiu, Yang; Kong, Jing; Fu, Yuhong; Liu, Yujie; Wang, Chong; Quan, Jia; Wang, Qian; Xu, Wei; Yin, Lei; Cui, Jie; Xu, Yi; Curry, Stephen; Jiang, Shibo; Lu, Lu; Zhou, Xi.

Immunity ; 54(10): 2231-2244.e6, 2021 10 12.

Artigo Inglês | MEDLINE | ID: mdl-34555337

6.

A natural mutator allele shapes mutation spectrum variation in mice.

Sasani, Thomas A; Ashbrook, David G; Beichman, Annabel C; Lu, Lu; Palmer, Abraham A; Williams, Robert W; Pritchard, Jonathan K; Harris, Kelley.

Nature ; 605(7910): 497-502, 2022 05.

Artigo Inglês | MEDLINE | ID: mdl-35545679

7.

A genome-scale screen for synthetic drivers of T cell proliferation.

Legut, Mateusz; Gajic, Zoran; Guarino, Maria; Daniloski, Zharko; Rahman, Jahan A; Xue, Xinhe; Lu, Congyi; Lu, Lu; Mimitou, Eleni P; Hao, Stephanie; Davoli, Teresa; Diefenbach, Catherine; Smibert, Peter; Sanjana, Neville E.

Nature ; 603(7902): 728-735, 2022 03.

Artigo Inglês | MEDLINE | ID: mdl-35296855

8.

Molecular landscapes of human hippocampal immature neurons across lifespan.

Zhou, Yi; Su, Yijing; Li, Shiying; Kennedy, Benjamin C; Zhang, Daniel Y; Bond, Allison M; Sun, Yusha; Jacob, Fadi; Lu, Lu; Hu, Peng; Viaene, Angela N; Helbig, Ingo; Kessler, Sudha K; Lucas, Timothy; Salinas, Ryan D; Gu, Xiaosong; Chen, H Isaac; Wu, Hao; Kleinman, Joel E; Hyde, Thomas M; Nauen, David W; Weinberger, Daniel R; Ming, Guo-Li; Song, Hongjun.

Nature ; 607(7919): 527-533, 2022 07.

Artigo Inglês | MEDLINE | ID: mdl-35794479

9.

Attenuated replication and pathogenicity of SARS-CoV-2 B.1.1.529 Omicron.

Shuai, Huiping; Chan, Jasper Fuk-Woo; Hu, Bingjie; Chai, Yue; Yuen, Terrence Tsz-Tai; Yin, Feifei; Huang, Xiner; Yoon, Chaemin; Hu, Jing-Chu; Liu, Huan; Shi, Jialu; Liu, Yuanchen; Zhu, Tianrenzheng; Zhang, Jinjin; Hou, Yuxin; Wang, Yixin; Lu, Lu; Cai, Jian-Piao; Zhang, Anna Jinxia; Zhou, Jie; Yuan, Shuofeng; Brindley, Melinda A; Zhang, Bao-Zhong; Huang, Jian-Dong; To, Kelvin Kai-Wang; Yuen, Kwok-Yung; Chu, Hin.

Nature ; 603(7902): 693-699, 2022 03.

Artigo Inglês | MEDLINE | ID: mdl-35062016

10.

Haplotype-resolved 3D chromatin architecture of the hybrid pig.

Lin, Yu; Li, Jing; Gu, Yiren; Jin, Long; Bai, Jingyi; Zhang, Jiaman; Wang, Yujie; Liu, Pengliang; Long, Keren; He, Mengnan; Li, Diyan; Liu, Can; Han, Ziyin; Zhang, Yu; Li, Xiaokai; Zeng, Bo; Lu, Lu; Kong, Fanli; Sun, Ying; Fan, Yongliang; Wang, Xun; Wang, Tao; Jiang, An'an; Ma, Jideng; Shen, Linyuan; Zhu, Li; Jiang, Yanzhi; Tang, Guoqing; Fan, Xiaolan; Liu, Qingyou; Li, Hua; Wang, Jinyong; Chen, Li; Ge, Liangpeng; Li, Xuewei; Tang, Qianzi; Li, Mingzhou.

Genome Res ; 34(2): 310-325, 2024 Mar 20.

Artigo Inglês | MEDLINE | ID: mdl-38479837

11.

GenomeMUSter mouse genetic variation service enables multitrait, multipopulation data integration and analysis.

Ball, Robyn L; Bogue, Molly A; Liang, Hongping; Srivastava, Anuj; Ashbrook, David G; Lamoureux, Anna; Gerring, Matthew W; Hatoum, Alexander S; Kim, Matthew J; He, Hao; Emerson, Jake; Berger, Alexander K; Walton, David O; Sheppard, Keith; El Kassaby, Baha; Castellanos, Francisco; Kunde-Ramamoorthy, Govindarajan; Lu, Lu; Bluis, John; Desai, Sejal; Sundberg, Beth A; Peltz, Gary; Fang, Zhuoqing; Churchill, Gary A; Williams, Robert W; Agrawal, Arpana; Bult, Carol J; Philip, Vivek M; Chesler, Elissa J.

Genome Res ; 34(1): 145-159, 2024 Feb 07.

Artigo Inglês | MEDLINE | ID: mdl-38290977

12.

SARS-CoV-2 evolution from the BA.2.86 to JN.1 variants: unexpected consequences.

Wang, Xinling; Lu, Lu; Jiang, Shibo.

Trends Immunol ; 45(2): 81-84, 2024 02.

Artigo Inglês | MEDLINE | ID: mdl-38302341

13.

A novel quantitative trait locus implicates Msh3 in the propensity for genome-wide short tandem repeat expansions in mice.

Maksimov, Mikhail O; Wu, Cynthia; Ashbrook, David G; Villani, Flavia; Colonna, Vincenza; Mousavi, Nima; Ma, Nichole; Lu, Lu; Pritchard, Jonathan K; Goren, Alon; Williams, Robert W; Palmer, Abraham A; Gymrek, Melissa.

Genome Res ; 33(5): 689-702, 2023 May.

Artigo Inglês | MEDLINE | ID: mdl-37127331

14.

Efficient combinatorial targeting of RNA transcripts in single cells with Cas13 RNA Perturb-seq.

Wessels, Hans-Hermann; Méndez-Mancilla, Alejandro; Hao, Yuhan; Papalexi, Efthymia; Mauck, William M; Lu, Lu; Morris, John A; Mimitou, Eleni P; Smibert, Peter; Sanjana, Neville E; Satija, Rahul.

Nat Methods ; 20(1): 86-94, 2023 01.

Artigo Inglês | MEDLINE | ID: mdl-36550277

15.

West Nile virus spread in Europe: Phylogeographic pattern analysis and key drivers.

Lu, Lu; Zhang, Feifei; Oude Munnink, Bas B; Munger, Emmanuelle; Sikkema, Reina S; Pappa, Styliani; Tsioka, Katerina; Sinigaglia, Alessandro; Dal Molin, Emanuela; Shih, Barbara B; Günther, Anne; Pohlmann, Anne; Ziegler, Ute; Beer, Martin; Taylor, Rachel A; Bartumeus, Frederic; Woolhouse, Mark; Aarestrup, Frank M; Barzon, Luisa; Papa, Anna; Lycett, Samantha; Koopmans, Marion P G.

PLoS Pathog ; 20(1): e1011880, 2024 Jan.

Artigo Inglês | MEDLINE | ID: mdl-38271294

16.

Androgen receptor-mediated CD8⁺ T cell stemness programs drive sex differences in antitumor immunity.

Yang, Chao; Jin, Jingsi; Yang, Yuanqin; Sun, Hongxiang; Wu, Lingling; Shen, Mingyi; Hong, Xiaochuan; Li, Wenwen; Lu, Lu; Cao, Dongqing; Wang, Xinran; Sun, Jing; Ye, Youqiong; Su, Bing; Deng, Liufu.

Immunity ; 55(9): 1747, 2022 Sep 13.

Artigo Inglês | MEDLINE | ID: mdl-36103859

17.

A pan-sarbecovirus vaccine based on RBD of SARS-CoV-2 original strain elicits potent neutralizing antibodies against XBB in non-human primates.

Liu, Zezhong; Zhou, Jie; Wang, Xinling; Xu, Wei; Teng, Zheng; Chen, Hongyou; Chen, Min; Zhang, Guangxu; Wang, Yuanzhou; Huang, Jinghe; Wang, Qian; Jiang, Shibo; Lu, Lu.

Proc Natl Acad Sci U S A ; 120(11): e2221713120, 2023 03 14.

Artigo Inglês | MEDLINE | ID: mdl-36897979

18.

An inducible hACE2 transgenic mouse model recapitulates SARS-CoV-2 infection and pathogenesis in vivo.

Liu, Kuo; Tang, Muxue; Xu, Wei; Meng, Xinfeng; Jin, Hengwei; Han, Maoying; Pu, Jing; Li, Yutang; Jiao, Fanke; Sun, Ruilin; Shen, Ruling; Lui, Kathy O; Lu, Lu; Zhou, Bin.

Proc Natl Acad Sci U S A ; 120(25): e2207210120, 2023 06 20.

Artigo Inglês | MEDLINE | ID: mdl-37307455

19.

Systems genetics analyses reveals key genes related to behavioral traits in the striatum of CFW mice.

Han, Zhe; Yang, Chunhua; He, Hongjie; Huang, Tingting; Yin, Quanting; Tian, Geng; Wu, Yuyong; Hu, Wei; Lu, Lu; Bajpai, Akhilesh Kumar; Mi, Jia; Xu, Fuyi.

J Neurosci ; 2024 May 22.

Artigo Inglês | MEDLINE | ID: mdl-38777602

20.

Temporal Dynamics, Discovery, and Emergence of Human-Transmissible RNA Viruses.

Lu, Lu; Zhang, Feifei; Brierley, Liam; Robertson, Gail; Chase-Topping, Margo; Lycett, Samantha; Woolhouse, Mark.

Mol Biol Evol ; 41(1)2024 Jan 03.

Artigo Inglês | MEDLINE | ID: mdl-38241079

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Broad neutralization of SARS-CoV-2 variants by an inhalable bispecific single-domain antibody.

Antivirals with common targets against highly pathogenic viruses.

Identification of Required Host Factors for SARS-CoV-2 Infection in Human Cells.

Androgen receptor-mediated CD8⁺ T cell stemness programs drive sex differences in antitumor immunity.

Inhibition of viral suppressor of RNAi proteins by designer peptides protects from enteroviral infection in vivo.

A natural mutator allele shapes mutation spectrum variation in mice.

A genome-scale screen for synthetic drivers of T cell proliferation.

Molecular landscapes of human hippocampal immature neurons across lifespan.

Attenuated replication and pathogenicity of SARS-CoV-2 B.1.1.529 Omicron.

Haplotype-resolved 3D chromatin architecture of the hybrid pig.

GenomeMUSter mouse genetic variation service enables multitrait, multipopulation data integration and analysis.

SARS-CoV-2 evolution from the BA.2.86 to JN.1 variants: unexpected consequences.

A novel quantitative trait locus implicates Msh3 in the propensity for genome-wide short tandem repeat expansions in mice.

Efficient combinatorial targeting of RNA transcripts in single cells with Cas13 RNA Perturb-seq.

West Nile virus spread in Europe: Phylogeographic pattern analysis and key drivers.

Androgen receptor-mediated CD8⁺ T cell stemness programs drive sex differences in antitumor immunity.

A pan-sarbecovirus vaccine based on RBD of SARS-CoV-2 original strain elicits potent neutralizing antibodies against XBB in non-human primates.

An inducible hACE2 transgenic mouse model recapitulates SARS-CoV-2 infection and pathogenesis in vivo.

Systems genetics analyses reveals key genes related to behavioral traits in the striatum of CFW mice.

Temporal Dynamics, Discovery, and Emergence of Human-Transmissible RNA Viruses.