Detalhe da pesquisa
1.
Alkene Oxyamination Using Malonoyl Peroxides: Preparation of Pyrrolidines and Isoxazolidines.
J Org Chem
; 83(12): 6728-6740, 2018 06 15.
Artigo
Inglês
| MEDLINE | ID: mdl-29812939
2.
Synthesis of 4-Arylthieno[2,3-b]pyridines and 4-Aminothieno[2,3-b]pyridines via a Regioselective Bromination of Thieno[2,3-b]pyridine.
J Org Chem
; 80(24): 12594-8, 2015 Dec 18.
Artigo
Inglês
| MEDLINE | ID: mdl-26584084
3.
Covalent hits and where to find them.
SLAS Discov
; 29(3): 100142, 2024 Apr.
Artigo
Inglês
| MEDLINE | ID: mdl-38278484
4.
Optimization of Potent Ligands for the E3 Ligase DCAF15 and Evaluation of Their Use in Heterobifunctional Degraders.
J Med Chem
; 67(7): 5538-5566, 2024 Apr 11.
Artigo
Inglês
| MEDLINE | ID: mdl-38513086
5.
Fragment screening at AstraZeneca: developing the next generation biophysics fragment set.
RSC Med Chem
; 13(9): 1052-1057, 2022 Sep 21.
Artigo
Inglês
| MEDLINE | ID: mdl-36324499
6.
Exploration of piperidine 3D fragment chemical space: synthesis and 3D shape analysis of fragments derived from 20 regio- and diastereoisomers of methyl substituted pipecolinates.
RSC Med Chem
; 13(12): 1614-1620, 2022 Dec 14.
Artigo
Inglês
| MEDLINE | ID: mdl-36545433
7.
Put a ring on it: application of small aliphatic rings in medicinal chemistry.
RSC Med Chem
; 12(4): 448-471, 2021 Apr 28.
Artigo
Inglês
| MEDLINE | ID: mdl-33937776
8.
Optimization of a Series of 2,3-Dihydrobenzofurans as Highly Potent, Second Bromodomain (BD2)-Selective, Bromo and Extra-Terminal Domain (BET) Inhibitors.
J Med Chem
; 64(15): 10711-10741, 2021 08 12.
Artigo
Inglês
| MEDLINE | ID: mdl-34260229
9.
Optimization of Potent ATAD2 and CECR2 Bromodomain Inhibitors with an Atypical Binding Mode.
J Med Chem
; 63(10): 5212-5241, 2020 05 28.
Artigo
Inglês
| MEDLINE | ID: mdl-32321240
10.
Cellular Target Engagement Approaches to Monitor Epigenetic Reader Domain Interactions.
SLAS Discov
; 25(2): 163-175, 2020 02.
Artigo
Inglês
| MEDLINE | ID: mdl-31875412
11.
A Qualified Success: Discovery of a New Series of ATAD2 Bromodomain Inhibitors with a Novel Binding Mode Using High-Throughput Screening and Hit Qualification.
J Med Chem
; 62(16): 7506-7525, 2019 08 22.
Artigo
Inglês
| MEDLINE | ID: mdl-31398032