Detalhe da pesquisa
1.
Characterization of Enzymes Involved in Nintedanib Metabolism in Humans.
Drug Metab Dispos
; 51(6): 733-742, 2023 06.
Artigo
Inglês
| MEDLINE | ID: mdl-36927840
2.
Sex-, Species-, and Tissue-Specific Metabolism of Empagliflozin in Male Mouse Kidney Forms an Unstable Hemiacetal Metabolite (M466/2) That Degrades to 4-Hydroxycrotonaldehyde, a Reactive and Cytotoxic Species.
Chem Res Toxicol
; 28(1): 103-15, 2015 Jan 20.
Artigo
Inglês
| MEDLINE | ID: mdl-25489797
3.
In vitro predictability of drug-drug interaction likelihood of P-glycoprotein-mediated efflux of dabigatran etexilate based on [I]2/IC50 threshold.
Drug Metab Dispos
; 42(2): 257-63, 2014 Feb.
Artigo
Inglês
| MEDLINE | ID: mdl-24212378
4.
Impact of endogenous esterase activity on in vitro p-glycoprotein profiling of dabigatran etexilate in Caco-2 monolayers.
Drug Metab Dispos
; 42(2): 250-6, 2014 Feb.
Artigo
Inglês
| MEDLINE | ID: mdl-24212377
5.
Simultaneous absolute protein quantification of transporters, cytochromes P450, and UDP-glucuronosyltransferases as a novel approach for the characterization of individual human liver: comparison with mRNA levels and activities.
Drug Metab Dispos
; 40(1): 83-92, 2012 Jan.
Artigo
Inglês
| MEDLINE | ID: mdl-21994437
6.
The metabolism and disposition of the oral dipeptidyl peptidase-4 inhibitor, linagliptin, in humans.
Drug Metab Dispos
; 38(4): 667-78, 2010 Apr.
Artigo
Inglês
| MEDLINE | ID: mdl-20086031
7.
The metabolism and disposition of the oral direct thrombin inhibitor, dabigatran, in humans.
Drug Metab Dispos
; 36(2): 386-99, 2008 Feb.
Artigo
Inglês
| MEDLINE | ID: mdl-18006647
8.
Hepatic differentiation of human iPSCs in different 3D models: A comparative study.
Int J Mol Med
; 40(6): 1759-1771, 2017 Dec.
Artigo
Inglês
| MEDLINE | ID: mdl-29039463
9.
Usefulness of A Model-Based Approach for Estimating In Vitro P-Glycoprotein Inhibition Potency in a Transcellular Transport Assay.
J Pharm Sci
; 105(2): 891-896, 2016 Feb.
Artigo
Inglês
| MEDLINE | ID: mdl-26869433