Detalhe da pesquisa
1.
The three cytokines IL-1ß, IL-18, and IL-1α share related but distinct secretory routes.
J Biol Chem
; 294(21): 8325-8335, 2019 05 24.
Artigo
Inglês
| MEDLINE | ID: mdl-30940725
2.
Th1 cytokines are more effective than Th2 cytokines at licensing anti-tumour functions in CD40-activated human macrophages in vitro.
Eur J Immunol
; 44(1): 162-72, 2014 Jan.
Artigo
Inglês
| MEDLINE | ID: mdl-24114634
3.
Deubiquitinases regulate the activity of caspase-1 and interleukin-1ß secretion via assembly of the inflammasome.
J Biol Chem
; 288(4): 2721-33, 2013 Jan 25.
Artigo
Inglês
| MEDLINE | ID: mdl-23209292
4.
Efficacy and pharmacodynamic effect of anti-CD73 and anti-PD-L1 monoclonal antibodies in combination with cytotoxic therapy: observations from mouse tumor models.
Cancer Biol Ther
; 25(1): 2296048, 2024 12 31.
Artigo
Inglês
| MEDLINE | ID: mdl-38206570
5.
Sphingosine regulates the NLRP3-inflammasome and IL-1ß release from macrophages.
Eur J Immunol
; 42(3): 716-25, 2012 Mar.
Artigo
Inglês
| MEDLINE | ID: mdl-22105559
6.
Combinatorial Immunotherapy with Agonistic CD40 Activates Dendritic Cells to Express IL12 and Overcomes PD-1 Resistance.
Cancer Immunol Res
; 11(10): 1332-1350, 2023 10 04.
Artigo
Inglês
| MEDLINE | ID: mdl-37478171
7.
Design and Preclinical Evaluation of a Novel B7-H4-Directed Antibody-Drug Conjugate, AZD8205, Alone and in Combination with the PARP1-Selective Inhibitor AZD5305.
Clin Cancer Res
; 29(6): 1086-1101, 2023 03 14.
Artigo
Inglês
| MEDLINE | ID: mdl-36355054
8.
Local Delivery of SBRT and IL12 by mRNA Technology Overcomes Immunosuppressive Barriers to Eliminate Pancreatic Cancer.
bioRxiv
; 2023 Nov 02.
Artigo
Inglês
| MEDLINE | ID: mdl-37961513
9.
The dynamics and mechanisms of interleukin-1alpha and beta nuclear import.
Traffic
; 10(1): 16-25, 2009 Jan.
Artigo
Inglês
| MEDLINE | ID: mdl-18939951
10.
Interleukin-1α expression precedes IL-1ß after ischemic brain injury and is localised to areas of focal neuronal loss and penumbral tissues.
J Neuroinflammation
; 8: 186, 2011 Dec 29.
Artigo
Inglês
| MEDLINE | ID: mdl-22206506
11.
Activity of murine surrogate antibodies for durvalumab and tremelimumab lacking effector function and the ability to deplete regulatory T cells in mouse models of cancer.
MAbs
; 13(1): 1857100, 2021.
Artigo
Inglês
| MEDLINE | ID: mdl-33397194
12.
Nuclear retention of IL-1 alpha by necrotic cells: a mechanism to dampen sterile inflammation.
Eur J Immunol
; 39(11): 2973-80, 2009 Nov.
Artigo
Inglês
| MEDLINE | ID: mdl-19839011
13.
Intratumoral IL12 mRNA Therapy Promotes TH1 Transformation of the Tumor Microenvironment.
Clin Cancer Res
; 26(23): 6284-6298, 2020 12 01.
Artigo
Inglês
| MEDLINE | ID: mdl-32817076
14.
Structural and functional characterization of C0021158, a high-affinity monoclonal antibody that inhibits Arginase 2 function via a novel non-competitive mechanism of action.
MAbs
; 12(1): 1801230, 2020.
Artigo
Inglês
| MEDLINE | ID: mdl-32880207
15.
Intratumoral immunotherapy with TLR7/8 agonist MEDI9197 modulates the tumor microenvironment leading to enhanced activity when combined with other immunotherapies.
J Immunother Cancer
; 7(1): 244, 2019 09 11.
Artigo
Inglês
| MEDLINE | ID: mdl-31511088
16.
An adaptive signaling network in melanoma inflammatory niches confers tolerance to MAPK signaling inhibition.
J Exp Med
; 214(6): 1691-1710, 2017 06 05.
Artigo
Inglês
| MEDLINE | ID: mdl-28450382
17.
Boron-Based Inhibitors of the NLRP3 Inflammasome.
Cell Chem Biol
; 24(11): 1321-1335.e5, 2017 Nov 16.
Artigo
Inglês
| MEDLINE | ID: mdl-28943355
18.
Transformation of the tumour microenvironment by a CD40 agonist antibody correlates with improved responses to PD-L1 blockade in a mouse orthotopic pancreatic tumour model.
Oncotarget
; 7(14): 18508-20, 2016 Apr 05.
Artigo
Inglês
| MEDLINE | ID: mdl-26918344
19.
Enhancement of antibody-dependent cell-mediated cytotoxicity by endowing IgG with FcαRI (CD89) binding.
MAbs
; 7(4): 743-51, 2015.
Artigo
Inglês
| MEDLINE | ID: mdl-25970007
20.
Understanding the influence of the tumor microenvironment on macrophage responses to CD40 agonists.
Oncoimmunology
; 3(1): e27615, 2014 Jan 01.
Artigo
Inglês
| MEDLINE | ID: mdl-24790792