Detalhe da pesquisa
1.
Identification of epidermal growth factor receptor-tyrosine kinase inhibitor targeting the VP1 pocket of human rhinovirus.
Antimicrob Agents Chemother
; 68(3): e0106423, 2024 Mar 06.
Artigo
Inglês
| MEDLINE | ID: mdl-38349161
2.
Monitoring drug-target interactions through target engagement-mediated amplification on arrays and in situ.
Nucleic Acids Res
; 50(22): e129, 2022 12 09.
Artigo
Inglês
| MEDLINE | ID: mdl-36189884
3.
Inhibition of Insulin-Regulated Aminopeptidase by Imidazo [1,5-α]pyridines-Synthesis and Evaluation.
Int J Mol Sci
; 25(5)2024 Feb 21.
Artigo
Inglês
| MEDLINE | ID: mdl-38473764
4.
Development of a chemical probe against NUDT15.
Nat Chem Biol
; 16(10): 1120-1128, 2020 10.
Artigo
Inglês
| MEDLINE | ID: mdl-32690945
5.
A FabG inhibitor targeting an allosteric binding site inhibits several orthologs from Gram-negative ESKAPE pathogens.
Bioorg Med Chem
; 30: 115898, 2021 01 15.
Artigo
Inglês
| MEDLINE | ID: mdl-33388594
6.
MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool.
Nature
; 508(7495): 215-21, 2014 Apr 10.
Artigo
Inglês
| MEDLINE | ID: mdl-24695224
7.
Prediction of intracellular exposure bridges the gap between target- and cell-based drug discovery.
Proc Natl Acad Sci U S A
; 114(30): E6231-E6239, 2017 07 25.
Artigo
Inglês
| MEDLINE | ID: mdl-28701380
8.
Quantitative Interpretation of Intracellular Drug Binding and Kinetics Using the Cellular Thermal Shift Assay.
Biochemistry
; 57(48): 6715-6725, 2018 12 04.
Artigo
Inglês
| MEDLINE | ID: mdl-30418016
9.
A drug screening assay on cancer cells chronically adapted to acidosis.
Cancer Cell Int
; 18: 147, 2018.
Artigo
Inglês
| MEDLINE | ID: mdl-30263014
10.
Corrigendum: MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool.
Nature
; 544(7651): 508, 2017 04 26.
Artigo
Inglês
| MEDLINE | ID: mdl-28447629
11.
Diverse heterocyclic scaffolds as dCTP pyrophosphatase 1 inhibitors. Part 2: Pyridone- and pyrimidinone-derived systems.
Bioorg Med Chem Lett
; 27(15): 3219-3225, 2017 08 01.
Artigo
Inglês
| MEDLINE | ID: mdl-28655422
12.
Binding to and Inhibition of Insulin-Regulated Aminopeptidase by Macrocyclic Disulfides Enhances Spine Density.
Mol Pharmacol
; 89(4): 413-24, 2016 Apr.
Artigo
Inglês
| MEDLINE | ID: mdl-26769413
13.
Virtual Screening for Transition State Analogue Inhibitors of IRAP Based on Quantum Mechanically Derived Reaction Coordinates.
J Chem Inf Model
; 55(9): 1984-93, 2015 Sep 28.
Artigo
Inglês
| MEDLINE | ID: mdl-26252078
14.
Immunomodulatory activity of commonly used drugs on Fc-receptor-mediated human natural killer cell activation.
Cancer Immunol Immunother
; 63(6): 627-41, 2014 Jun.
Artigo
Inglês
| MEDLINE | ID: mdl-24682538
15.
All-photonic kinase inhibitors: light-controlled release-and-report inhibition.
Chem Sci
; 15(18): 6897-6905, 2024 May 08.
Artigo
Inglês
| MEDLINE | ID: mdl-38725520
16.
Identification and evaluation of small-molecule inhibitors against the dNTPase SAMHD1 via a comprehensive screening funnel.
iScience
; 27(2): 108907, 2024 Feb 16.
Artigo
Inglês
| MEDLINE | ID: mdl-38318365
17.
In vitro and in vivo activities of 2-aminopyrazines and 2-aminopyridines in experimental models of human African trypanosomiasis.
Antimicrob Agents Chemother
; 57(2): 1012-8, 2013 Feb.
Artigo
Inglês
| MEDLINE | ID: mdl-23254423
18.
Rapid PROTAC Discovery Platform: Nanomole-Scale Array Synthesis and Direct Screening of Reaction Mixtures.
ACS Med Chem Lett
; 14(12): 1882-1890, 2023 Dec 14.
Artigo
Inglês
| MEDLINE | ID: mdl-38116431
19.
Optimization of N-Piperidinyl-Benzimidazolone Derivatives as Potent and Selective Inhibitors of 8-Oxo-Guanine DNA Glycosylase 1.
ChemMedChem
; 18(1): e202200310, 2023 01 03.
Artigo
Inglês
| MEDLINE | ID: mdl-36128847
20.
A high content screening assay for discovery of antimycobacterial compounds based on primary human macrophages infected with virulent Mycobacterium tuberculosis.
Tuberculosis (Edinb)
; 135: 102222, 2022 07.
Artigo
Inglês
| MEDLINE | ID: mdl-35738191