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1.
Chemistry ; 29(55): e202302160, 2023 Oct 02.
Artigo em Inglês | MEDLINE | ID: mdl-37434274

RESUMO

Water electrolysis has been considered a promising technology for the conversion of renewables to hydrogen. However, preventing mixing of products (H2 and O2 ) and exploring cost-efficient electrolysis components remains challenging for conventional water electrolyzers. Herein, we designed a membrane-free decoupled water electrolysis system by using graphite felt supported nickel-cobalt phosphate (GF@Nix Coy -P) material as a tri-functional (redox mediator, hydrogen evolution reaction (HER), oxygen evolution reaction (OER)) electrode. The versatile GF@Ni1 Co1 -P electrode obtained by a one-step electrodeposition not only exhibits high specific capacity (176 mAh g-1 at 0.5 A g-1 ) and long cycle life (80 % capacity retention after 3000 cycles) as a redox mediator, but also has relatively outstanding catalytic activities for HER and OER. The excellent properties of the GF@Nix Coy -P electrode endow this decoupled system with more flexibility for H2 production by fluctuating renewable energies. This work provides guidance for multifunctional applications of transition metal compounds between energy storage and electrocatalysis.

2.
Am J Bot ; 110(10): e16227, 2023 10.
Artigo em Inglês | MEDLINE | ID: mdl-37561668

RESUMO

PREMISE: The ever-increasing temperatures of the Anthropocene may facilitate plant invasions. To date, studies of temperature effects on alien plants have mainly focused on aboveground plant traits but ignored belowground traits, which may confound predictions of plant invasion risks. METHODS: The temperature effects on the root growth dynamics of two alien shrubs, invasive Mimosa sepiaria and naturalized Corchorus capsulari, were studied using a 3D, transparent growth system under five temperature treatments (day/night: 18°C/13°C to 34°C/29°C) that cover the present and future warming temperature scenarios in China. We measured root depth and width growth in response to temperature treatments over 84 days. We also investigated intra- and interspecific competition of paired plants of the two species grown together at the five temperatures. RESULTS: Shoot growth of M. sepiaria and C. capsularis was optimal at the mid-range temperature. Root growth, however, was faster at the highest temperature (34°C/29°C) for M. sepiaria, but decreased for C. capsularis as temperatures increased. Root depth growth was more sensitive than root width for both species during neighbor competition. Compared to C. capsularis, M. sepiaria had relatively greater advantage during intra- and interspecific competition with increasing temperature, possibly because of its better root growth at high temperatures. CONCLUSIONS: These results suggest that temperature increases can improve the performance of some alien plants by facilitating width and depth growth of their roots. This enhancement requires serious attention when managing and predicting invasion risk.


Assuntos
Plantas , Temperatura , China
3.
J Surg Oncol ; 127(6): 905-920, 2023 May.
Artigo em Inglês | MEDLINE | ID: mdl-36826370

RESUMO

BACKGROUND AND OBJECTIVES: We aim to evaluate the analgesic efficacy and safety of erector spinae plane block (ESPB) for postoperative analgesia in breast cancer surgeries. METHODS: PubMed, Web of Science, CBM, Embase, Cochrane, Wanfang, VIPP, and CNKI were searched to identify published eligible randomized controlled trials. The primary results were the postoperative 24 h morphine consumption and pain scores, while the secondary outcomes included pain scores at other times, press times of patient-controlled intravenous analgesia (PCIA), times to request for first rescue analgesia, the incidence of request for rescue analgesia, opioid-related complications, nerve blocks related complications and patient satisfaction. RESULTS: We included 20 studies meeting the inclusion criteria, which involved 1293 participants. The morphine consumption and the pain scores during 24 h postoperatively were significantly decreased in the ESPB group versus the control group (p < 0.00001). Furthermore, ESPB also reduced pain scores at other time points, press times of PCIA, and times to first rescue analgesia requirement. Meanwhile, there was a lower incidence of postoperative nausea and vomiting, and skin pruritus in the ESPB group than in the control group. CONCLUSIONS: Compared to general anesthesia alone, ESPB combined with general anesthesia can effectively reduce the postoperative pain intensity within 48 h and opioid consumption within 24 h after breast cancer surgery, and reduce the incidence of opioid and nerve blocks related complications.


Assuntos
Neoplasias da Mama , Humanos , Feminino , Analgésicos Opioides , Dor Pós-Operatória , Analgesia Controlada pelo Paciente , Derivados da Morfina
4.
Sichuan Da Xue Xue Bao Yi Xue Ban ; 54(4): 798-803, 2023 Jul.
Artigo em Chinês | MEDLINE | ID: mdl-37545077

RESUMO

Objective: To examine the application effect of body mechanics principles in the process of health workers doffing personal protective equipment (PPE). Methods: A total of 360 health workers from a Fangcang shelter hospital, also known as alternate care site, in Shanghai were involved in a centralized 1-day training concerning essential skills for taking off PPE. The training was focused on integrating body mechanics principles, including expanding the support surface, lowering the center of gravity, reducing the shift in the the center of gravity, using the principle of leverage, and creating the appropriate operating space, in the PPE doffing process. Through remote video monitoring and recording, observations were made of the physical stability, pollution risks, and operational smoothness of the health workers when they applied body mechanics principles in their actions. Results: The results of binary logistic regression showed that, compared with the actions taken without applying body mechanics principles, performing the operation of the body leaning forward and then slightly leaning backward was positively correlated with stability in the doffing process (odds ratio [O R]=3.291, 95% confidence interval [ CI]: 1.627-6.656), negatively correlated with pollution risks ( OR=0.203, 95% CI: 0.100-0.412), and positively correlated with operational smoothness ( OR=20.847, 95% CI: 8.061-53.916); performing the operation of taking off the boot sleeve in a horse-riding stance, with one foot standing ahead of the other, was positively correlated with stability ( OR=5.299, 95% CI: 1.041-26.957), negatively correlated with pollution risks ( OR=0.079, 95% CI: 0.009-0.692), and positive correlated with operational smoothness ( OR=16.729, 95% CI: 1.238-226.077); performing the operation of taking off the boot sleeve by lifting the heel and then the toes was positively correlated with stability ( OR=19.361, 95% CI: 8.391-44.671), negatively correlated with pollution risks ( OR=0.181, 95% CI: 0.084-0.393), and positively correlated with operational smoothness ( OR=10.977, 95% CI: 3.764-32.008); performing the operation of the leaning forward and keeping the face looking forward when taking off the mask was positively correlated with stability ( OR=2.935, 95% CI: 1.412-6.101), negatively correlated with pollution risks ( OR=0.123, 95% CI: 0.059-0.258), and positively correlated with operational smoothness ( OR=18.126, 95% CI: 6.665-49.297). Conclusion: In the process of medical staffs doffing PPE, correct and proper mechanical postures and actions can effectively assist medical staffs to maintain balance and stability and reduce the risks of infection, which has major significance and should be widely incorporated in personal protection skills training and applied in clinical practice.


Assuntos
Doença pelo Vírus Ebola , Hospitais Especializados , Animais , Cavalos , Doença pelo Vírus Ebola/prevenção & controle , Transmissão de Doença Infecciosa do Paciente para o Profissional/prevenção & controle , Unidades Móveis de Saúde , China , Equipamento de Proteção Individual
5.
Angew Chem Int Ed Engl ; 62(5): e202217071, 2023 Jan 26.
Artigo em Inglês | MEDLINE | ID: mdl-36468671

RESUMO

The electrochemical nitrate reduction reaction (NO3 RR) is an appealing technology for regulating the nitrogen cycle. Metallic iron is one of the well-known electrocatalysts for NO3 RR, but it suffers from poor durability due to leaching and oxidation of iron during the electrocatalytic process. In this work, a graphene-nanochainmail-protected iron nanoparticle (Fe@Gnc) electrocatalyst is reported. It displays superior nitrate removal efficiency and high nitrogen selectivity. Notably, the catalyst delivers exceptional stability and durability, with the nitrate removal rate and nitrogen selectivity remained ≈96 % of that of the first time after up to 40 cycles (24 h for one cycle). As expected, the conductive graphene nanochainmail provides robust protection for the internal iron active sites, allowing Fe@Gnc to maintain its long-lasting electrochemical nitrate catalytic activity. This research proposes a workable solution for the scientific challenge of poor lasting ability of iron-based electrocatalysts in large-scale industrialization.

6.
Angew Chem Int Ed Engl ; 62(38): e202310383, 2023 Sep 18.
Artigo em Inglês | MEDLINE | ID: mdl-37550249

RESUMO

One-dimensional fiber architecture serves as an excellent catalyst support. The orderly arrangement of active materials on such a fiber substrate can enhance catalytic performance by exposing more active sites and facilitating mass diffusion; however, this remains a challenge. We developed an interfacial assembly strategy for the orderly distribution of metal nanocrystals on different fiber substrates to optimize their electrocatalytic performance. Using electrochemical nitrate reduction reaction (NO3 - RR) as a representative reaction, the iron-based nanofibers (Fe/NFs) assembly structure achieved an excellent nitrate removal capacity of 2317 mg N/g Fe and N2 selectivity up to 97.2 %. This strategy could promote the rational design and synthesis of fiber-based electrocatalysts.

7.
Int J Clin Pract ; 75(4): e13860, 2021 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-33236451

RESUMO

OBJECTIVE: This study aimed to compare the diagnostic performance of vital touch tissue quantification (VTQ) and virtual touch tissue imaging quantification (VTIQ) in diagnosing infants with biliary atresia (BA) from jaundiced infants. METHODS: In this study, 26 jaundiced infants with BA, 33 jaundiced infants without BA, and 40 normal infants were enrolled. The hepatic shear wave velocity (SWV) of each infant was determined by VTQ and VTIQ examinations, respectively. Then, the receiver operating characteristic (ROC) curves were drawn and the area under the curve (AUC) and optimal cut-off values were calculated to evaluate the sensitivities and specificities of VTIQ and VTQ for BA. RESULTS: The mean values of SWV of the control group measured by VTQ and VTIQ were (1.09 ± 0.18) m/s and (1.36 ± 0.21) m/s, respectively. The mean values of SWV of the non-BA group measured by VTQ and VTIQ were (1.30 ± 0.28) m/s and (1.52 ± 0.29) m/s, respectively. The mean values of SWV of the BA group measured by VTQ and VTIQ were (2.36 ± 0.36) m/s and (2.43 ± 0.29) m/s, respectively. The diagnostic threshold of VTQ and VTIQ to diagnose BA was 1.77 and 1.92 m/s. The sensitivities of VTQ and VTIQ to diagnose BA were 90.9% and 95.5%. The specificities of VTQ and VTIQ to diagnose BA were 68.4% and 78.9%. CONCLUSION: Vital touch tissue quantification and VTIQ could help distinguish infants with BA from jaundiced infants by measuring the liver SWV values. VTIQ has higher sensitivity and specificity than VTQ.


Assuntos
Atresia Biliar , Técnicas de Imagem por Elasticidade , Atresia Biliar/diagnóstico por imagem , Diagnóstico Diferencial , Humanos , Lactente , Fígado/diagnóstico por imagem , Curva ROC , Reprodutibilidade dos Testes , Sensibilidade e Especificidade
8.
Prenat Diagn ; 38(11): 829-834, 2018 10.
Artigo em Inglês | MEDLINE | ID: mdl-30035813

RESUMO

OBJECTIVES: The objective of the study is to evaluate the diagnostic value of ultrasonography in cystic lesions of the adrenal gland. METHODS: Twenty-two cases of adrenal cystic lesions found in the foetal period were retrospectively analysed. All foetuses were followed up by ultrasound after birth, and all lesions were confirmed by operation or ultrasound-guided biopsy. RESULTS: Sixteen foetuses displayed anechoic findings, and 6 had patchy mixed echoic findings. Nevertheless, the characteristics of these lesions changed in the neonatal period: 7 cases presented as anechoic and 15 cases presented as mixed echoic. The final pathology revealed simple cysts in 7 cases, intracystic haemorrhage in 9 cases, and 6 cases of spontaneous haemorrhage of the adrenal glands. CONCLUSIONS: The ultrasonographic findings of foetal cystic lesions in the adrenal gland and the change they undergo after birth may provide valuable information for clinical diagnosis.


Assuntos
Doenças das Glândulas Suprarrenais/diagnóstico por imagem , Cistos/diagnóstico por imagem , Doenças Fetais/diagnóstico por imagem , Ultrassonografia Pré-Natal , Feminino , Humanos , Gravidez , Estudos Retrospectivos
9.
J BUON ; 23(4): 1041-1048, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-30358209

RESUMO

PURPOSE: To investigate the characteristics of lymph node (LN) metastasis of papillary thyroid carcinoma (PTC) with ultrasonography (US) and spiral computed tomography (CT) and the significance of their combination in the diagnosis and prognosis of LN metastasis. METHODS: A total of 93 PTC patients admitted to and treated in the oncology department of our hospital were randomly enrolled in this study. LN imaging signs were explored by US, CT and their combination. Through the comparison with pathological findings, the diagnostic efficiency of three methods in LN metastasis in patients with PTC was analyzed. Postoperatively, all patients were followed up for 1-3 years to analyze the relationship between LN metastasis and the prognosis of PTC. RESULTS: Among 93 PTC patients, 69 (74.19%) had LN metastasis, and 24 (25.81%) had not. US examination revealed that metastatic LN were hypoechoic and obviously calcified, and had aspect ratio >1 and strong blood flow signals. Among them, there were significant differences in calcification and blood flow between LN metastasis group and non-metastasis group (p<0.05). CT images indicated that metastatic LN were swollen, had low-density and were calcified with abundant blood flow signals. In addition, the edge, calcification and CT reinforced examination showed obvious differences between the LN metastasis group and the non-metastasis group (p<0.05). The sensitivity, specificity and accuracy of US alone in the diagnosis of LN metastasis were clearly better than those of CT alone (p<0.05), while their combination was better than both US and CT alone in the sensitivity, specificity and accuracy in the diagnosis of LN metastasis (p<0.05). Follow-up data suggested that the 3-year recurrence or metastasis rates of patients in the metastasis and non-metastasis groups were 4.54 and 11.27%, respectively, showing a statistically significant difference (p<0.05). CONCLUSIONS: US combined with CT can make up for the deficiencies of each examination alone, and improve the sensitivity and specificity of PTC LN metastasis detection. It is worthy of clinical promotion.


Assuntos
Linfonodos/diagnóstico por imagem , Câncer Papilífero da Tireoide/diagnóstico por imagem , Neoplasias da Glândula Tireoide/diagnóstico por imagem , Humanos , Linfonodos/patologia , Metástase Linfática , Imagem Multimodal/métodos , Prognóstico , Câncer Papilífero da Tireoide/patologia , Neoplasias da Glândula Tireoide/patologia , Tomografia Computadorizada por Raios X/métodos , Ultrassonografia/métodos
10.
Artigo em Chinês | MEDLINE | ID: mdl-25997269

RESUMO

Total hip replacement (THR) is replacing the prosthesis stem similar to human bone that takes advantage of the material with both good mechanical properties and biocompatibility to the damaged articular surface. Thus it can not only alleviate or even eliminate the pain but also effectively maintain the joint stability and freedom and restore its normal performance. Finite element analysis was used in this study to establish a 3D model of artificial hip stem, and explore its fatigue properties of different materials to ensure the safety and reliability. The calculating obtained two results of different metal hip prosthesis, including lifetime and deformation. The minimum service life of titanium prosthesis reaches 568 million times, which satisfies ISO standards, while the stainless steel does not suit to be a prosthesis material.


Assuntos
Prótese de Quadril , Teste de Materiais , Falha de Prótese , Artroplastia de Quadril , Análise de Elementos Finitos , Articulação do Quadril , Humanos , Modelos Anatômicos , Reprodutibilidade dos Testes , Aço Inoxidável , Titânio
11.
Angew Chem Int Ed Engl ; 54(16): 4870-5, 2015 Apr 13.
Artigo em Inglês | MEDLINE | ID: mdl-25728521

RESUMO

Water oxidation is the key step in natural and artificial photosynthesis for solar-energy conversion. As this process is thermodynamically unfavorable and is challenging from a kinetic point of view, the development of highly efficient catalysts with low energy cost is a subject of fundamental significance. Herein, we report on iron-based films as highly efficient water-oxidation catalysts. The films can be quickly deposited onto electrodes from Fe(II) ions in acetate buffer at pH 7.0 by simple cyclic voltammetry. The extremely low iron loading on the electrodes is critical for improved atom efficiency for catalysis. Our results showed that this film could catalyze water oxidation in neutral phosphate solution with a turnover frequency (TOF) of 756 h(-1) at an applied overpotential of 530 mV. The significance of this approach includes the use of earth-abundant iron, the fast and simple method for catalyst preparation, the low catalyst loading, and the large TOF for O2 evolution in neutral aqueous media.

12.
J Fluoresc ; 24(1): 189-95, 2014 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-23974700

RESUMO

A new daunorubicin has been synthesized and structurally characterized. The interaction of native calf thymus DNA (ctDNA) with 3'-azido-daunorubicin thiosemicarbazone (ADNRT) was investigated under simulated physiological conditions by multi-spectroscopic techniques, viscometric measurements and molecular modeling study. It concluded that ADNRT could intercalate into the base pairs of ctDNA, and the fluorescence quenching by ctDNA was static quenching type. Thermodynamic parameters calculated suggested that the binding of ADNRT to ctDNA was mainly driven by hydrophobic interactions. The relative viscosity of ctDNA increased with the addition of ADNRT, which confirmed the intercalation mode. Furthermore, molecular modeling studies corroborate the above experimental results.


Assuntos
DNA/química , Daunorrubicina/análogos & derivados , Tiossemicarbazonas/química , Animais , Bovinos , Daunorrubicina/química , Modelos Moleculares , Espectrometria de Fluorescência , Viscosidade
13.
Radiol Oncol ; 58(3): 386-396, 2024 Sep 01.
Artigo em Inglês | MEDLINE | ID: mdl-39287160

RESUMO

BACKGROUND: Extrathyroidal extension was related with worse survival for patients with papillary thyroid carcinoma. For its preoperative evaluation, we measured and compared the predicting value of sonographic method and ultrasonic radiomics method in nodules of papillary thyroid carcinoma. PATIENTS AND METHODS: Data from 337 nodules were included and divided into training group and validation group. For ultrasonic radiomics method, a best model was constructed based on clinical characteristics and ultrasonic radiomic features. The predicting value was calculated then. For sonographic method, the results were calculated using all samples. RESULTS: For ultrasonic radiomics method, we constructed 9 models and selected the extreme gradient boosting model for its highest accuracy (0.77) and area under curve (0.813) in validation group. The accuracy and area under curve of sonographic method was 0.70 and 0.569. Meanwhile. We found that the top-6 important features of xgboost model included no clinical characteristics, all of whom were high-dimensional radiomic features. CONCLUSIONS: The study showed the superior value of ultrasonic radiomics method to sonographic method for preoperative detection of extrathyroidal extension in papillary thyroid carcinoma. Furthermore, high-dimensional radiomic features were more important than clinical characteristics.


Assuntos
Câncer Papilífero da Tireoide , Neoplasias da Glândula Tireoide , Ultrassonografia , Humanos , Estudos Retrospectivos , Feminino , Masculino , Neoplasias da Glândula Tireoide/diagnóstico por imagem , Neoplasias da Glândula Tireoide/patologia , Ultrassonografia/métodos , Câncer Papilífero da Tireoide/diagnóstico por imagem , Câncer Papilífero da Tireoide/patologia , Pessoa de Meia-Idade , Adulto , Idoso , Invasividade Neoplásica/diagnóstico por imagem , Valor Preditivo dos Testes , Radiômica
14.
World J Gastroenterol ; 30(7): 705-713, 2024 Feb 21.
Artigo em Inglês | MEDLINE | ID: mdl-38515948

RESUMO

BACKGROUND: The detection rate of peptic ulcer in children is improving, with development of diagnostic procedures. Gastroscopy is the gold standard for the diagnosis of peptic ulcer, but it is an invasive procedure. Gastrointestinal contrast-enhanced ultrasonography (CEUS) has the advantages of being painless, noninvasive, nonradioactive, easy to use, and safe. AIM: To investigate the clinical value of CEUS for diagnosis and treatment of peptic ulcer in children. METHODS: We investigated 43 children with digestive tract symptoms in our hospital from January 2021 to June 2022. All children were examined by routine ultrasound, gastrointestinal CEUS, and gastroscopy. The pathological results of gastroscopy were taken as the gold standard. Routine ultrasonography was performed before gastrointestinal CEUS. Conventional ultrasound showed the thickness of the gastroduodenal wall, gastric peristalsis, and the adjacent organs and tissues around the abdominal cavity. Gastrointestinal CEUS recorded the thickness of the gastroduodenal wall; the size, location and shape of the ulcer; gastric peristalsis; and adjacent organs and tissues around the abdominal cavity. The results of routine ultrasound and gastrointestinal ultrasound were compared with those of gastroscopy to evaluate the diagnostic results and coincidence rate of routine ultrasound and gastrointestinal CEUS. All children received informed consent from their guardians for CEUS. This study was reviewed and approved by the hospital medical ethics committee. RESULTS: Among the 43 children, 17 (15 male, 2 female) were diagnosed with peptic ulcer by gastroscopy. There were 26 children with nonpeptic ulcer. There were eight cases of peptic ulcer and 35 of nonpeptic ulcer diagnosed by conventional ultrasound. The diagnostic coincidence rate of peptic ulcer in children diagnosed by conventional ultrasound was 79.1% (34/43), which was significantly different from that of gastroscopy (P = 0.033). It indicates that the coincidence rate of gastrointestinal contrast-enhanced ultrasound and gastroscope is low. Fifteen cases of peptic ulcer and 28 of nonpeptic ulcer were diagnosed by CEUS. The diagnostic coincidence rate of peptic ulcer in children was 95.3% (41/43). There was no significant difference between CEUS and gastroscopy (P = 0.655). It indicates that the coincidence rate of gastrointestinal contrast-enhanced ultrasound and gastroscope is high. CONCLUSION: Gastrointestinal CEUS has a high coincidence rate in the diagnosis of peptic ulcer in children, and can be used as a preliminary examination method.


Assuntos
Meios de Contraste , Úlcera Péptica , Criança , Humanos , Masculino , Feminino , Úlcera , Úlcera Péptica/diagnóstico por imagem , Úlcera Péptica/terapia , Ultrassonografia/métodos
15.
Comput Biol Med ; 169: 107898, 2024 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-38176210

RESUMO

Accurate segmentation of the thyroid gland in ultrasound images is an essential initial step in distinguishing between benign and malignant nodules, thus facilitating early diagnosis. Most existing deep learning-based methods to segment thyroid nodules are learned from only a single view or two views, which limits the performance of segmenting nodules at different scales in complex ultrasound scanning environments. To address this limitation, this study proposes a multi-view learning model, abbreviated as MLMSeg. First, a deep convolutional neural network is introduced to encode the features of the local view. Second, a multi-channel transformer module is designed to capture long-range dependency correlations of global view between different nodules. Third, there are semantic relationships of structural view between features of different layers. For example, low-level features and high-level features are endowed with hidden relationships in the feature space. To this end, a cross-layer graph convolutional module is proposed to adaptively learn the correlations of high-level and low-level features by constructing graphs across different layers. In addition, in the view fusion, a channel-aware graph attention block is devised to fuse the features from the aforementioned views for accurate segmentation of thyroid nodules. To demonstrate the effectiveness of the proposed method, extensive comparative experiments were conducted with 14 baseline methods. MLMSeg achieved higher Dice coefficients (92.10% and 83.84%) and Intersection over Union scores (86.60% and 73.52%) on two different thyroid datasets. The exceptional segmentation capability of MLMSeg for thyroid nodules can greatly assist in localizing thyroid nodules and facilitating more precise measurements of their transverse and longitudinal diameters, which is of significant clinical relevance for the diagnosis of thyroid nodules.


Assuntos
Nódulo da Glândula Tireoide , Humanos , Ultrassonografia , Redes Neurais de Computação , Semântica , Processamento de Imagem Assistida por Computador
16.
Med Image Anal ; 91: 103039, 2024 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-37992495

RESUMO

Ultrasound has become the most widely used modality for thyroid nodule diagnosis, due to its portability, real-time feedback, lack of toxicity, and low cost. Recently, the computer-aided diagnosis (CAD) of thyroid nodules has attracted significant attention. However, most existing techniques can only be applied to either static images with prominent features (manually selected from scanning videos) or rely on 'black boxes' that cannot provide interpretable results. In this study, we develop a user-friendly framework for the automated diagnosis of thyroid nodules in ultrasound videos, by simulating the typical diagnostic workflow used by radiologists. This process consists of two orderly part-to-whole tasks. The first interprets the characteristics of each image using prior knowledge, to obtain corresponding frame-wise TI-RADS scores. Associated embedded representations not only provide diagnostic information for radiologists but also reduce computational costs. The second task models temporal contextual information in an embedding vector sequence and selectively enhances important information to distinguish benign and malignant thyroid nodules, thereby improving the efficiency and generalizability of the proposed framework. Experimental results demonstrated this approach outperformed other state-of-the-art video classification methods. In addition to assisting radiologists in understanding model predictions, these CAD results could further ease diagnostic workloads and improve patient care.


Assuntos
Nódulo da Glândula Tireoide , Humanos , Nódulo da Glândula Tireoide/diagnóstico por imagem , Nódulo da Glândula Tireoide/patologia , Sensibilidade e Especificidade , Diagnóstico Diferencial , Ultrassonografia/métodos , Diagnóstico por Computador/métodos
17.
Environ Sci Pollut Res Int ; 30(13): 36485-36501, 2023 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-36543991

RESUMO

Improving carbon emission efficiency (CEE) has emerged as a critical way for Regional Comprehensive Economic Partnership (RCEP) members to promote carbon reduction in the context of climate change mitigation and carbon neutrality. The super-efficiency slacks-based measure (SBM) model, which considers non-desired outputs, is adopted to comprehensively assess the current state and trend of CEE in 15 RCEP countries from a spatio-temporal dynamic perspective, and the global Malmquist-Luenberger (GML) index is coupled to quantify the spatial and temporal differences and dynamic changes. Following that, taking into account the spatial characteristics of CEE, the extended STIRPAT model and the spatial Durbin model are combined to further investigate the primary influencing factors of CEE. It is found that (1) the CEE of RCEP members is generally poor and unevenly distributed in temporal and spatial dimensions, with significant room for improvement and an overall positive spatial autocorrelation; (2) CEE varies considerably among RCEP members, with developed countries far outstripping developing countries in terms of both the current status and trend of CEE; (3) on a dynamic level, the GML index exhibits W-shaped fluctuations, with technological progress acting as the dominant force; and (4) in terms of spillover effects, affluence and economic agglomeration inhibit CEE enhancement, whereas technology level and investment capacity facilitate it. The findings will be useful in developing carbon-neutral plans for various countries as well as coordinated sustainable development for RCEP regions.


Assuntos
Investimentos em Saúde , Condições Sociais , Carbono , Mudança Climática , Análise Espacial , China , Desenvolvimento Econômico , Eficiência
18.
World J Gastrointest Surg ; 15(3): 346-361, 2023 Mar 27.
Artigo em Inglês | MEDLINE | ID: mdl-37032802

RESUMO

BACKGROUND: The relationship between hepatitis B surface antigen (HBsAg)-positive carrier status and liver cancer has been extensively studied. However, the epigenetic changes that occur during progression from HBsAg-positive carrier status or cirrhosis to liver cancer are unknown. The epigenetic modification of DNA hydroxymethylation is critical in tumor development. Further, 5-hydroxymethylcytosine (5hmC) is an important base for DNA demethylation and epigenetic regulation. It is also involved in the assembly of chromosomes and the regulation of gene expression. However, the mechanism of action of 5hmC in HBsAg-positive carriers or patients with cirrhosis who develop liver cancer has not been fully elucidated. AIM: To investigate the possible epigenetic mechanism of HBsAg-positive carriers and hepatocellular carcinoma (HCC) progression from cirrhosis. METHODS: Forty HBsAg-positive carriers, forty patients with liver cirrhosis, and forty patients with liver cancer admitted to the First People's Hospital of Yongkang between March 2020 and November 2021 were selected as participants. Free DNA was extracted using a cf-DNA kit. cfDNA was extracted by 5hmC DNA sequencing for principal component analysis, the expression profiles of the three groups of samples were detected, and the differentially expressed genes (DEGs) modified by hydroxymethylation were screened. Bioinformatic analysis was used to enrich DEGs, such as in biological pathways. RESULTS: A total of 16455 hydroxymethylated genes were identified. Sequencing results showed that 32 genes had significant 5hmC modification differences between HBsAg carriers and liver cancer patients, of which 30 were upregulated and 2 downregulated in patients with HCC compared with HBsAg-positive carriers. Significant 5hmC modification differences between liver cirrhosis and liver cancer patients were identified in 20 genes, of which 17 were upregulated and 3 were downregulated in patients with HCC compared with those with cirrhosis. These genes may have potential loci that are undiscovered or unelucidated, which contribute to the development and progression of liver cancer. Analysis of gene ontology enrichment and Kyoto Encyclopedia of Genes and Genomes showed that the major signaling pathways involved in the differential genes were biliary secretion and insulin secretion. The analysis of protein interactions showed that the important genes in the protein-protein interaction network were phosphoenolpyruvate carboxykinase and solute carrier family 2. CONCLUSION: The occurrence and development of liver cancer involves multiple genes and pathways, which may be potential targets for preventing hepatitis B carriers from developing liver cancer.

19.
Adv Mater ; 35(46): e2304695, 2023 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-37488087

RESUMO

The electrocatalytic reduction of nitrate (NO3 - ) to nitrogen (N2 ) is an environmentally friendly approach for efficient N-cycle management (toward a nitrogen-neutral cycle). However, poor catalyst durability and the competitive hydrogen evolution reaction significantly impede its practical application. Interface-chemistry engineering, utilizing the close relationship between the catalyst surface/interface microenvironment and electron/proton transfer process, has facilitated the development of catalysts with high intrinsic activity and physicochemical durability. This study reports the synthesis of a nitrogen-doped carbon-coated rice-like iron nitride (RL-Fe2 N@NC) electrocatalyst with excellent electrocatalytic nitrate-reduction reaction activity (high N2 selectivity (≈96%) and NO3 - conversion (≈86%)). According to detailed mechanistic investigations by in situ tests and theoretical calculations, the strong hydrogenation ability of iron nitride and enhanced nitrate enrichment of the system synergistically contribute to the rapid hydrogenation of nitrogen-containing species, increasing the intrinsic activity of the catalyst and reducing the occurrence of the competing hydrogen-evolution side reaction. Moreover, RL-Fe2 N@NC shows excellent stability, retaining good NO3 - -to-N2 electrocatalysis activity for more than 40 cycles (one cycle per day). This paper could guide the interfacial design of Fe-based composite nanostructures for electrocatalytic nitrate reduction, facilitating a shift toward nitrogen neutrality.

20.
Environ Sci Pollut Res Int ; 29(39): 59190-59210, 2022 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-35380325

RESUMO

Rapid urban expansion and energy transformation are two major challenges facing China. Many researchers have explored urban compactness and energy efficiency, but there is little literature on the coordinated development of the two. Therefore, this paper takes 35 cities in China as research object: The urban compactness evaluation index system is established, and the score is calculated using the entropy weight method; considering the bad output, SBM is used to calculate the green total factor energy efficiency (GTFEE); and the coupling coordination degree model is used to calculate their coordinated degree. The following conclusions can be inferred: (1) Although China's urban compactness has increased, it has not maintained a steady upward trend. Some more developed cities have the phenomenon of compactness rising first and then falling; (2) The overall GTFEE shows a continuous upward trend, but there is still much room for improvement, and regional disparities are significant; (3) The degree of coordination between the two maintains a steady upward trend, and the city's compactness lags behind GTFEE. Based on the findings of the study, this paper proposes policy recommendations that can serve as a reference for key decision-makers and are critical in promoting China's urbanization and energy transformation.


Assuntos
Conservação de Recursos Energéticos , Desenvolvimento Econômico , China , Cidades , Eficiência , Urbanização
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