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1.
Environ Monit Assess ; 196(10): 905, 2024 Sep 07.
Artigo em Inglês | MEDLINE | ID: mdl-39243344

RESUMO

The apple orchards in Liaoning, one of the four major apple-producing areas in Bohai Bay, Northeast China, play a crucial role in regulating the carbon sink effect. However, there is limited information on the variation in carbon flux and its influential factors in apple orchards in this region. To address this, CO2 flux data were monitored throughout the entire apple growth seasons from April to November in 2017 and 2018 in the apple (Malus pumila Mill. cv Hanfu) orchard in Shenyang, China. The energy closure of the apple orchard was calculated, and variations in net ecosystem exchange (NEE) at different time scales and its response to environmental factors were analyzed. Our results showed that the energy balance ratio of the apple was 0.74 in 2017 and 1.38 in 2018. NEE was generally positive in April and November and negative from May to October, indicating a strong carbon sink throughout the growth season. The daily average NEE ranged from - 0.103 to 0.094 mg m-2 s-1 in 2017 and from - 0.134 to 0.059 mg m-2 s-1 in 2018, with the lowest values observed in June and July. NEE was negatively correlated with net radiation, atmospheric temperature, saturated vapor pressure deficit, and soil temperature. These findings provide valuable insights for predicting carbon flux in orchard ecosystems within the context of global climate change.


Assuntos
Dióxido de Carbono , Ecossistema , Monitoramento Ambiental , Malus , Malus/crescimento & desenvolvimento , China , Dióxido de Carbono/análise , Sequestro de Carbono , Estações do Ano , Poluentes Atmosféricos/análise , Solo/química , Ciclo do Carbono , Agricultura
2.
Breast Cancer Res Treat ; 194(2): 279-295, 2022 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-35666367

RESUMO

PURPOSE: To compare the clinicopathologic features and prognosis of pleomorphic invasive lobular carcinoma (P-ILC) and classic ILC (C-ILC) according to the biomarker profile. METHODS: A total of 667 C-ILCs and 133 P-ILCs between 2011 and 2021 were included. Clinicopathologic features and stromal tumor-infiltrating lymphocytes (sTILs) status were evaluated. P-ILCs were divided into subtypes based on ER/PR and HER2 expression. The overall survival and disease-free survival (DFS) of patients were compared among matched P-ILCs, C-ILCs, and invasive ductal carcinomas (IDCs) with biomarker subtypes. RESULTS: Compared to C-ILCs, P-ILCs had greater tumor sizes and stages, fewer ER-positive, more HER2-positive, triple negative (TN), and Ki-67 > 20% tumors (P < 0.05). P-ILCs were subdivided into ER+ (63.1%), HER2+ (21.1%) and TN (15.8%). ER+ P-ILCs were mainly showed trabecular and solid growth patterns. Apocrine and solid features were more strongly associated with HER2+ P-ILCs and TN-P-ILCs, respectively. The prognosis of each biomarker group (ER+, HER2+ and TN) differed by subtype. The P-ILC biomarker subtypes had worse prognosis than the same subtypes in the IDC group, while there was no difference between the P-ILC and the C-ILC counterparts. Solid variants of P-ILC had the worst prognosis. Bone was the most common metastatic site in ER+ P-ILCs and TN-P-ILCs. HER2+ P-ILCs tended to metastasize to the brain and liver. DFS of HER2+ P-ILCs and TN-P-ILCs were worse than that of ER+ P-ILCs. Lacking lobular carcinoma in situ and sTILs ≤ 10% were associated with worse survival of ER+ P-ILCs and TN-P-ILCs, respectively. For HER2+ P-ILCs, Ki-67 > 20% and sTILs ≤ 10% were significant factors for lower DFS. CONCLUSION: P-ILCs is an aggressive subtype of ILCs. Analyzing the prognostic factors of P-ILCs with heterogeneous morphological and biomarker characteristics is helpful for creating an individualized treatment.


Assuntos
Neoplasias da Mama , Carcinoma Ductal de Mama , Carcinoma Lobular , Carcinoma Ductal de Mama/metabolismo , Carcinoma Lobular/patologia , Feminino , Humanos , Antígeno Ki-67/genética , Prognóstico , Receptor ErbB-2/metabolismo
3.
Bioorg Chem ; 76: 386-391, 2018 02.
Artigo em Inglês | MEDLINE | ID: mdl-29245120

RESUMO

Six new polyoxygenated seco-cyclohexenes, artahongkongenes A-F (1-6), together with six known analogues (7-12) were isolated from the stems and leaves of Artabotrys hongkongensis. Their structures were elucidated by extensive spectroscopic methods. All new compounds were evaluated for their cytotoxicities against five human cancer cell lines: HL-60, SMMC-7721, A-549, MCF-7 and SW480 in vitro. New seco-cyclohexenes 1-6 showed significant inhibitory effects against various human cancer cell lines with IC50 values ranging from 0.26 to 16.58 µM.


Assuntos
Annonaceae/química , Antineoplásicos Fitogênicos/farmacologia , Cicloexenos/farmacologia , Antineoplásicos Fitogênicos/química , Antineoplásicos Fitogênicos/isolamento & purificação , Linhagem Celular Tumoral , Cicloexenos/química , Cicloexenos/isolamento & purificação , Ensaios de Seleção de Medicamentos Antitumorais , Humanos , Estrutura Molecular , Folhas de Planta/química , Caules de Planta/química
4.
Abdom Radiol (NY) ; 2024 Sep 13.
Artigo em Inglês | MEDLINE | ID: mdl-39269504

RESUMO

PURPOSE: This meta-analysis was conducted to assess the relative diagnostic effectiveness of [18F]FDG PET/CT and MRI in the initial detection of ovarian cancer. METHODS: A thorough literature search was conducted using PubMed, Embase, and Web of Science databases to locate relevant studies published up to April 2024. The selected studies were those that evaluated diagnostic performance of [18F]FDG PET/CT and MRI for the initial detection of ovarian cancer. Sensitivity and specificity metrics were analyzed employing the DerSimonian and Laird random-effects model, with further transformation utilizing the Freeman-Tukey double arcsine method. The quality of included studies was appraised using the Quality Assessment of Diagnostic Accuracy Studies (QUADAS-2) tool. RESULTS: The meta-analysis included 23 articles encompassing a total of 1973 patients. The sensitivity of [18F]FDG PET/CT was found to be higher than that of MRI (0.94 vs. 0.87, P = 0.02). In terms of specificity, [18F]FDG PET/CT and MRI demonstrated similar values (0.87 vs. 0.86, P = 0.90). An assessment of publication bias using the funnel plot asymmetry test revealed no significant bias for any outcomes (Egger's test: all P > 0.05). CONCLUSIONS: Our meta-analysis reveals that [18F]FDG PET/CT exhibits higher sensitivity while maintaining similar specificity compared to MRI for the initial detection of ovarian cancer. However, the substantial heterogeneity observed across studies may influence these findings. Consequently, larger-scale prospective studies are necessary to validate these results.

5.
Medicine (Baltimore) ; 100(12): e25174, 2021 Mar 26.
Artigo em Inglês | MEDLINE | ID: mdl-33761697

RESUMO

INTRODUCTION: Immune dysregulation, polyendocrinopathy, enteropathy, and X-linked (IPEX) syndrome is a rare monogenic autoimmune disease, which is caused by mutations in the forkhead box protein 3 gene, can affect various systems. The typical clinical manifestations of IPEX are enteropathy, type 1 diabetes mellitus, and skin diseases. However, some atypical phenotypes can easily be misdiagnosed clinically. PATIENT CONCERNS: A 9-year-and-7-month old patient suffered from recurrent wheezing, hematochezia, and eczematous dermatitis at the age of six months, but did not have any manifestations of autoimmune endocrinopathy. The patient was treated with glucocorticoids for more than six years, and he developed bronchiectasis. DIAGNOSIS: Whole exome sequencing revealed a hemizygous pathogenic mutation c.1010G>A, p. (Arg337Gln) in Forkhead box protein 3 gene (NM_014009.3). INTERVENTIONS: The patient was treated with oral mycophenolate mofetil combined with inhaled budesonide formoterol for six months after diagnosis. OUTCOMES: The respiratory symptoms of the patient seemed to be controlled but eczematous dermatitis progressed, which led the patient to give up the treatment. CONCLUSION: Early diagnosis and treatment of IPEX are crucial. Lung injury may be a major problem in the later stages of atypical IPEX, and mycophenolate mofetil seems to control the respiratory symptoms, but could induce significant skin side effects.


Assuntos
Diabetes Mellitus Tipo 1/congênito , Diarreia/diagnóstico , Doenças Genéticas Ligadas ao Cromossomo X/diagnóstico , Doenças do Sistema Imunitário/congênito , Combinação Budesonida e Fumarato de Formoterol/efeitos adversos , Combinação Budesonida e Fumarato de Formoterol/uso terapêutico , Criança , Diagnóstico Tardio , Diabetes Mellitus Tipo 1/diagnóstico , Diabetes Mellitus Tipo 1/tratamento farmacológico , Diabetes Mellitus Tipo 1/genética , Diarreia/tratamento farmacológico , Diarreia/genética , Proteína Forkhead Box O3/genética , Doenças Genéticas Ligadas ao Cromossomo X/tratamento farmacológico , Doenças Genéticas Ligadas ao Cromossomo X/genética , Humanos , Doenças do Sistema Imunitário/diagnóstico , Doenças do Sistema Imunitário/tratamento farmacológico , Doenças do Sistema Imunitário/genética , Masculino , Ácido Micofenólico/efeitos adversos , Ácido Micofenólico/uso terapêutico , Mutação Puntual , Medicamentos para o Sistema Respiratório/efeitos adversos , Medicamentos para o Sistema Respiratório/uso terapêutico
6.
Nat Prod Res ; 32(14): 1727-1732, 2018 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-29115148

RESUMO

A new polyoxygenated cyclohexene derivative, artahainanol A (1), together with three known analogues (2-4), was isolated from the stems and leaves of Artabotrys hainanensis. Among them, 1 is an unusual polyoxygenated cyclohexene containing 14 carbon atoms on the carbon skeleton. All known compounds (2-4) were isolated from the genus Artabotrys for the first time. The structure of 1 was elucidated by extensive spectroscopic methods and the known compounds were identified by comparisons with data reported in the literature. All isolated compounds were evaluated for their cytotoxicities against five human cancer cell lines: HL-60, SMMC-7721, A-549, MCF-7 and SW480 in vitro. Compounds 1-4 showed significant inhibitory effects against various human cancer cell lines with IC50 values ranging from 2.68 to 18.32 µM.


Assuntos
Annonaceae/química , Antineoplásicos Fitogênicos/química , Antineoplásicos Fitogênicos/farmacologia , Cicloexenos/química , Cicloexenos/farmacologia , Linhagem Celular Tumoral , Ensaios de Seleção de Medicamentos Antitumorais , Células HL-60 , Humanos , Concentração Inibidora 50 , Células MCF-7 , Espectroscopia de Ressonância Magnética , Estrutura Molecular , Folhas de Planta/química
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