Testing links between unfavorable living conditions, fast life-history strategy adoption, and overeating: a four-wave longitudinal study.

Although overeating increases risk for chronic illness and premature mortality, evolutionary life-history theorists posit that such behaviors arise as a potential outcome of using fast life-history strategies to function in environments that are harsh or unpredictable. To test this premise, we examined links between harsh, unpredictable living conditions (HULC), the adoption of fast life-history (LH) strategies, and overeating among early adolescents using a four-wave longitudinal design. Participants were 2547 Chinese adolescents (1202 girls, 1345 boys) who completed baseline questionnaires assessing experiences of HULC, preferences for use of fast LH strategies, and overeating. Measures were re-administered in follow-ups 7, 13, and 20 months later. Analyses indicated HULC predicted increased use of fast LH strategies within each gender. However, fast LH strategy adoption contributed to increases in overeating only among girls. Findings supported specific tenets of life-history theory and underscored gender as an important consideration in understanding links between living conditions, the adoption of fast LH strategies, and risk for overeating. Interventions focused on reducing poverty and increasing stable, nurturing family, and community environments may aid in reducing overeating and obesity for adolescents.

Efficacy and safety of granulocyte-macrophage colony-stimulating factor (GM-CSF) antibodies in COVID-19 patients: a meta-analysis.

OBJECTIVE: This study aims to determine the efficacy and safety of granulocyte-macrophage colony-stimulating factor (GM-CSF) antibodies in COVID-19 patients. METHODS: We searched Cochrane Library, PubMed, Embase, and ClinicalTrials.gov databases until July 27, 2022. Both randomized control trials (RCTs) and cohort studies were included and analyzed separately. The outcomes included mortality, incidence of invasive mechanical ventilation (IMV), ventilation improvement rate (need oxygen therapy to without oxygen therapy), secondary infection, and adverse events (AEs). The odds ratio (OR) with a 95% confidence interval (CI) was calculated by a random-effects meta-analysis model. RESULTS: Five RCTs and 2 cohort studies with 1726 COVID-19 patients were recruited (n = 866 in the GM-CSF antibody group and n = 891 in the control group). GM-CSF antibodies treatment reduced the incidence of IMV, which was supported by two cohort studies (OR 0.16; 95% CI 0.03, 0.74) and three RCTs (OR 0.62; 95% CI 0.41, 0.94). GM-CSF antibodies resulted in slight but not significant reductions in mortality (based on two cohort studies and five RCTs) and ventilation improvement (based on one cohort study and two RCTs). The sensitive analysis further showed the results of mortality and ventilation improvement rate became statistically significant when one included study was removed. Besides, GM-CSF antibodies did not increase the risks of the second infection (based on one cohort study and five RCTs) and AEs (based on five RCTs). CONCLUSION: GM-CSF antibody treatments may be an efficacious and well-tolerant way for the treatment of COVID-19. Further clinical evidence is still warranted.

Effectiveness of an Internet Dissonance-Based Eating Disorder Prevention Intervention Among Body-Dissatisfied Young Chinese Women.

Body image disturbances are widespread in highly populated, rapidly developing Asian nations such as China, but there are severe shortages of practitioners qualified to treat these issues. In such contexts, validated online interventions offer a potentially viable approach for addressing the lack of treatment resources. In this study, we evaluated effects of the eBody Project, an online, dissonance-based eating disorder prevention program, on functioning among body-dissatisfied young Chinese women. Participating women were randomly assigned to the 6-week eBody Project intervention (n = 191) versus an education brochure control condition (n = 181). Self-report assessments of eating disorder risk factors (body dissatisfaction, thin ideal internalization, depressive symptoms, restrained eating), self-esteem, body appreciation, and disordered eating were completed at baseline, posttreatment, and a 6-month follow-up. There were no intervention differences on outcomes before treatment but eBody Project women experienced significantly larger improvements on all outcomes following treatment and/or at follow-up compared to controls; corresponding effect sizes were small to medium. Results indicated the eBody Project program is a promising intervention for young women at risk for eating disorders in China and provide foundations for broad implementation in low- and middle-income countries where resources for in-person therapy and supervision are limited or unavailable altogether.

Resting-state functional network connectivity underlying eating disorder symptoms in healthy young adults.

Previous neuroimaging research of eating disorders such as anorexia nervosa and bulimia nervosa has mainly focused on clinical patients, indicating the crucial role of intrinsic connectivity networks involved in aberrant behavioral control (i.e., executive control network), reward reactivity (i.e., basal ganglia network), and excessive self-focused and body-focused ruminations (i.e., default mode network) in the onset and maintenance of eating disturbances. However, examinations of large-scale resting-state networks that support the role of cognitive control, reward sensitivity, and self-directed thinking in disordered eating have rarely involved non-clinical samples from the general population. This study, involving a total of 693 healthy young adults (68.69% females; mean age, 18.37 years), investigated these issues by using pre-defined functional regions of interest from the executive control network, basal ganglia network, default mode network, and a seed-based region of interest-to-region of interest approach. After statistically controlling for differences in age, sex, body mass index, and head motion, we observed significant associations of higher levels of eating disorder symptoms, especially bulimia-type eating (i.e., binge eating and a combination of binge eating and compensatory behaviors, such as purging via self-induced vomiting or laxative use, and compulsive exercise), with weaker intra-network and inter-network functional synchrony. These results remained significant after excluding underweight, overweight, and obese participants. These findings suggest that these neural circuits may play a key role in the symptoms of disordered eating in healthy adults. They further reveal that the less efficient information exchange within and between intrinsic networks associated with self-referential thinking, inhibitory control, and reward sensitivity are strongly related to eating disorder symptoms.

Online interpersonal sexual objectification experiences and Chinese adolescent girls' intuitive eating: The role of broad conceptualization of beauty and body appreciation.

Interpersonal sexual objectification experiences are pervasive in online communication contexts, and their influence on positive eating behaviors should not be ignored. Broad conceptualization of beauty refers to how widely women and girls define female beauty in terms of both internal and external characteristics, and body appreciation refers to loving, respecting, and holding a positive attitude toward the body. This study examined the association between online interpersonal sexual objectification (OISO) experiences and intuitive eating, as well as the mediating role of broad conceptualization of beauty and body appreciation. Participants were 1152 Chinese adolescent girls aged 11 to 15 years who completed a questionnaire survey measuring OISO experiences, broad conceptualization of beauty, body appreciation, and intuitive eating. The results showed a negative association of OISO experiences with broad conceptualization of beauty and intuitive eating. Mediation analysis using structural equation modeling showed a negative association of OISO experiences with intuitive eating through broad conceptualization of beauty and body appreciation. These results suggest that programs aiming to improve healthy eating behaviors could direct adolescent girls to criticize the appearance-focused mindset in online interaction and encourage them to focus on body functionality, such as health, creative endeavors, and communication with others.

Qzone use and depression among Chinese adolescents: A moderated mediation model.

BACKGROUND: Social networking sites (SNSs), which provide abundant social comparison opportunities, are ubiquitous around the world, especially among adolescents. In China, Qzone stands out as the most popular SNS. Due to the opportunity it provides for meticulous self-presentation, SNS may give the impression that others are doing better, which is detrimental to individuals' well-being. Based on social comparison theory, the current study aimed to investigate the association between Chinese adolescents' SNS (Qzone) use and depression, as well as the mediating role of negative social comparison and the moderating role of self-esteem. METHOD: A total of 764 adolescents (aged 12-18 years, M = 14.23, SD = 1.75), who had an active Qzone account, were recruited voluntarily to complete questionnaires on Qzone use intensity, negative social comparison on Qzone, self-esteem, and depression. RESULTS: More intense Qzone use was associated with higher level of negative social comparison on Qzone, which fully mediated the association between Qzone use and depression. Moreover, the mediating effect of negative social comparison on Qzone was moderated by self-esteem. The specific link between Qzone use and negative social comparison was weaker among adolescents with high self-esteem than those with low self-esteem. LIMITATIONS: As all the data in this study were self-reported and cross-sectional, causal associations cannot be identified. Additionally, the specific activities on SNS were not identified. CONCLUSIONS: Negative social comparison may be a key factor and mechanism accounting for the positive association between SNS use and depression, while self-esteem could protect adolescents from the adverse outcome of SNS use.