Detalhe da pesquisa
1.
Stereoselective Synthesis of ß, γ-Fused Bicyclic γ-Ureasultams via an Intramolecular Mannich and aza-Michael Addition Cascade.
Chemistry
; 30(28): e202400438, 2024 May 17.
Artigo
Inglês
| MEDLINE | ID: mdl-38470414
2.
Design, synthesis and mechanism studies of dual EZH2/BRD4 inhibitors for cancer therapy.
Bioorg Med Chem
; 91: 117386, 2023 08 15.
Artigo
Inglês
| MEDLINE | ID: mdl-37379621
3.
Harmine-based dual inhibitors targeting histone deacetylase (HDAC) and DNA as a promising strategy for cancer therapy.
Bioorg Chem
; 120: 105604, 2022 03.
Artigo
Inglês
| MEDLINE | ID: mdl-35051708
4.
Reductive C-C Coupling from Molecular Au(I) Hydrocarbyl Complexes: A Mechanistic Study.
J Am Chem Soc
; 143(6): 2509-2522, 2021 02 17.
Artigo
Inglês
| MEDLINE | ID: mdl-33544575
5.
Heterochromatin protects retinal pigment epithelium cells from oxidative damage by silencing p53 target genes.
Proc Natl Acad Sci U S A
; 115(17): E3987-E3995, 2018 04 24.
Artigo
Inglês
| MEDLINE | ID: mdl-29622681
6.
Progress in approved drugs from natural product resources.
Chin J Nat Med
; 22(3): 195-211, 2024 Mar.
Artigo
Inglês
| MEDLINE | ID: mdl-38553188
7.
Regioselective Olefination and Arylation of Arene-Tethered Diols Using the Easily Foldable Directing Groups.
Org Lett
; 26(7): 1463-1467, 2024 Feb 23.
Artigo
Inglês
| MEDLINE | ID: mdl-38349252
8.
Dual target PARP1/EZH2 inhibitors inducing excessive autophagy and producing synthetic lethality for triple-negative breast cancer therapy.
Eur J Med Chem
; 265: 116054, 2024 Feb 05.
Artigo
Inglês
| MEDLINE | ID: mdl-38134746
9.
Improving tumor sensitivity by the introduction of an ester chain to triaryl derivatives targeting PD-1/PD-L1.
Eur J Med Chem
; 271: 116433, 2024 May 05.
Artigo
Inglês
| MEDLINE | ID: mdl-38678826
10.
Discovery of Sibiriline derivatives as novel receptor-interacting protein kinase 1 inhibitors.
Eur J Med Chem
; 250: 115190, 2023 Mar 15.
Artigo
Inglês
| MEDLINE | ID: mdl-36801518
11.
Oxazole-4-carboxamide/butylated hydroxytoluene hybrids with GSK-3ß inhibitory and neuroprotective activities against Alzheimer's disease.
Eur J Med Chem
; 256: 115415, 2023 Aug 05.
Artigo
Inglês
| MEDLINE | ID: mdl-37172476
12.
Indirubin derivatives as bifunctional molecules inducing DNA damage and targeting PARP for the treatment of cancer.
Eur J Med Chem
; 261: 115843, 2023 Dec 05.
Artigo
Inglês
| MEDLINE | ID: mdl-37832229
13.
Aryl Halides as Halogenation Reagents in the Bromination and Iodination of Arene-Tethered Diols.
Org Lett
; 24(36): 6510-6514, 2022 09 16.
Artigo
Inglês
| MEDLINE | ID: mdl-36052998
14.
Discovery of precision targeting EZH2 degraders for triple-negative breast cancer.
Eur J Med Chem
; 238: 114462, 2022 Aug 05.
Artigo
Inglês
| MEDLINE | ID: mdl-35623249
15.
Heterochromatin inhibits cGAS and STING during oxidative stress-induced retinal pigment epithelium and retina degeneration.
Free Radic Biol Med
; 178: 147-160, 2022 01.
Artigo
Inglês
| MEDLINE | ID: mdl-34875339
16.
Histone Deacetylase and Enhancer of Zeste Homologue 2 Dual Inhibitors Presenting a Synergistic Effect for the Treatment of Hematological Malignancies.
J Med Chem
; 65(19): 12838-12859, 2022 10 13.
Artigo
Inglês
| MEDLINE | ID: mdl-36153841
17.
Parthenolide Derivatives as PKM2 Activators Showing Potential in Colorectal Cancer.
J Med Chem
; 64(23): 17304-17325, 2021 12 09.
Artigo
Inglês
| MEDLINE | ID: mdl-34847663
18.
The E3 Ligase PIAS1 Regulates p53 Sumoylation to Control Stress-Induced Apoptosis of Lens Epithelial Cells Through the Proapoptotic Regulator Bax.
Front Cell Dev Biol
; 9: 660494, 2021.
Artigo
Inglês
| MEDLINE | ID: mdl-34195189
19.
Standardized treatment and determinants on 9,059 syphilis-infected pregnant women during 2015-2018 in Hunan, China.
Sci Rep
; 10(1): 12026, 2020 07 21.
Artigo
Inglês
| MEDLINE | ID: mdl-32694571
20.
Paeoniae radix alba polysaccharides obtained via optimized extraction treat experimental autoimmune hepatitis effectively.
Int J Biol Macromol
; 164: 1554-1564, 2020 Dec 01.
Artigo
Inglês
| MEDLINE | ID: mdl-32735927