Brain-derived neurotrophic factor overexpression in taste buds diminishes chemotherapy induced taste loss.

Vismodegib is used in patients suffering from advanced basal cell carcinoma (BCC), but 100% of the patients taking it report dysgeusia and 50% discontinue the treatment. Treatment with neurotrophic factors can stimulate neuronal survival and functional improvement in injured organs. Here, we analysed novel transgenic mouse lines in which brain-derived neurotrophic factor (BDNF) is overexpressed in taste buds, to examine whether higher levels of BDNF would reduce or prevent negative side effects of vismodegib in the taste system. BDNF plays crucial roles for development, target innervation, and survival of gustatory neurons and taste buds. The behavioural test in this study showed that vehicle-treated wild-type mice prefered 10 mM sucrose over water, whereas vismodegib treatment in wild-type mice caused total taste loss. Gustducin-BDNF mice had a significantly increased preference for low concentration of sucrose solution over water compared to wild-type mice, and most importantly the transgenic mice were able to detect low concentrations of sucrose following vismodegib treatment. We evaluated taste cell morphology, identity, innervation and proliferation using immunohistochemistry. All drug-treated mice exhibited deficits, but because of a possible functional upcycled priming of the peripheral gustatory system, GB mice demonstrated better morphological preservation of the peripheral gustatory system. Our study indicates that overexpression of BDNF in taste buds plays a role in preventing degeneration of taste buds. Counteracting the negative side effects of vismodegib treatment might improve compliance and achieve better outcome in patients suffering from advanced BCC.

Post-traumatic growth as positive personality change: Challenges, opportunities, and recommendations.

OBJECTIVE: Post-traumatic growth typically refers to enduring positive psychological change experienced as a result of adversity, trauma, or highly challenging life circumstances. Critics have challenged insights from much of the prior research on this topic, pinpointing its significant methodological limitations. In response to these critiques, we propose that post-traumatic growth can be more accurately captured in terms of personality change-an approach that affords a more rigorous examination of the phenomenon. METHOD: We outline a set of conceptual and methodological questions and considerations for future work on the topic of post-traumatic growth. RESULTS: We provide a series of recommendations for researchers from across the disciplines of clinical/counseling, developmental, health, personality, and social psychology and beyond, who are interested in improving the quality of research examining resilience and growth in the context of adversity. CONCLUSION: We are hopeful that these recommendations will pave the way for a more accurate understanding of the ubiquity, durability, and causal processes underlying post-traumatic growth.

Cultural differences in coping with interpersonal tensions lead to divergent shorter- and longer-term affective consequences.

Culture influences how people cope with interpersonal tensions, with those from more collectivistic contexts (e.g. Chinese Americans (CA)) generally opting for strategies promoting social harmony whereas those from more individualistic contexts (e.g. European Americans (EA)) preferring confrontational strategies. The current study examined cultural differences in coping strategy choices and their linkages to immediate affective reactions and subsequent affective memories. Participants (N = 159) discussed hypothetical dilemmas with a disagreeable confederate matched by age group, gender, and cultural group. CA exhibited less positive affect reactivity (i.e. smaller decreases in positive affect) and greater positive affect recovery (i.e. greater increases in post-task positive affect) compared to EA, which was explained by CAs' appraisals of greater emotional support from the confederate and lower endorsement of defending one's opinions. In contrast, one week later, EA, but not CA, recalled experiencing more task positive affect and less task negative affect than originally reported. Cultural differences in negative affect memory discrepancies were explained by EAs' greater tendency to defend their opinions, relative to CA. Culture shapes coping choices, which predict affective consequences over different time scales.

Enduring Bonds: Duration and Contact in Close Relationships in Late Life.

BACKGROUND AND OBJECTIVES: Older adults maintain ties to long-duration social partners, some with whom have regular contact and some with whom have little contact. We asked whether these ties with little contact still offer a sense of connection and security, and buffer the effects of interpersonal stress in daily life. Helping older adults foster these ties may improve their mental health. RESEARCH DESIGN AND METHODS: Participants (n = 313) aged 65+ completed a baseline interview reporting duration and contact frequency of their closest ties. Then, participants completed ecological momentary assessments every 3 hr for 5-6 days, reporting their social encounters and mood. RESULTS: We classified ties according to duration (10+ years = long vs shorter duration) and frequency of contact (at least once a month = active vs dormant). Throughout the day, participants were more likely to have stressful encounters with long-duration active ties. Encounters with active ties were associated with more positive mood (regardless of duration) and encounters with long-duration dormant ties with more negative mood. Having more active ties buffered effects of interpersonal stress on mood, but more long-duration dormant ties exacerbated these effects. DISCUSSION AND IMPLICATIONS: Supporting social integration theory, ties with frequent contact were associated with positive mood. Surprisingly, long-duration ties with infrequent contact exacerbated effects of interpersonal stress on mood. Older adults who lack contact with long-duration social partners may be more sensitive to interpersonal stress. Future interventions might focus on phone or electronic media to increase contact with long-duration social partners.

Disentangling trait and daily experiences of uncertainty and meaning in life: implications for daily anxiety, negative affect, and somatic symptoms.

BACKGROUND: Although there is growing evidence supporting the association between intolerance of uncertainty (IU) and psychopathology, little is known about the covariation of IU and psychological distress day-to-day. The purpose of this ecological momentary assessment (EMA) study was to examine negative emotional and somatic correlates of trait IU and daily uncertainty, while investigating how a source of stability, meaning in life (MIL), might buffer against deleterious effects of IU and uncertainty. DESIGN AND METHODS: Adult community members (n = 62) from a mid-size town in the Rocky Mountain region completed baseline measures of IU and MIL and ecological momentary assessments (EMA) of meaning, uncertainty, affect, and somatic symptoms over the course of one week. RESULTS: Results indicate individuals high in trait IU experience more uncertainty day-to-day and greater distress when they feel uncertain compared to individuals lower in trait IU; however, MIL plays a stronger protective role for high IU compared to low IU individuals. CONCLUSIONS: These findings support and extend previous research showing IU is associated with psychological distress and that MIL may be a critical resource to cultivate. Interventions promoting meaning day-to-day may reduce the effects of uncertainty on the well-being of those highly intolerant of uncertainty.

Interdependencies Between Family and Friends in Daily Life: Personality Differences and Associations with Affective Well-Being Across the Lifespan.

Family and friends are central to human life and well-being. Yet, interdependencies between family and friends have scarcely been examined. How is the relative frequency of daily contact with family and friends (i.e., the friends/family-ratio) related to personality and to well-being? In an experience sampling study with 396 participants (M age= 40 years, range 14-88 years, 52% females), we studied how the friends/family-ratio in contact differed along Big Five personality trait scores and was connected to affective well-being across six daily measurements on nine days (average of 55 assessments). Most participants reported more daily contact with family than friends (i.e. they held a family orientation), but individual differences were substantial. More agreeable individuals reported a greater family orientation. More extraverted individuals reported more positive affect in the company of friends than with family. Age moderated the effect of the friends/family-ratio on positive affect. Younger adults reported less positive affect in the company of family, yet older adults reported more positive affect in the company of family, the more they were friendship oriented. We discuss how examining the friends/family-ratio extends previous knowledge on personality differences in social relationships, and how the friends/family-ratio yields promising, yet challenging, future directions in personality-relationship associations.

Valuing Negative Affect Weakens Affect-Health Linkages: Similarities and Differences Across Affect Valuation Measures.

Negative affect (NA) has been robustly linked to poorer psychological health, including greater depressive symptoms, personal burnout, and perceived stress. These associations, known as affect-health links, have been postulated by our research team to vary with different levels of negative affect valuation (NAV), such that people who evaluate NA states as more pleasant, helpful, appropriate, and/or meaningful may show weaker affect-health links. Another affect valuation construct is ideal NA, which is the degree to which people ideally want to experience NA states (i.e., desirability of affective states). The current study extends previous research by examining these two different measures of affect valuation (NAV and ideal NA) and comparing the extent to which they moderate affect-health links for psychological health and functioning. Participants from the Health and Daily Experiences (HEADE) study (N = 162 comprising of 56 younger adults and 106 older adults) completed questionnaires in a laboratory setting and ecological momentary assessments of NA 6 times a day for 7 consecutive days (i.e., trait NA). The results demonstrated that the two affect valuation constructs were distinct and showed different patterns of buffering effects. NAV attenuated the association between trait NA and depressive symptoms, personal burnout, and intolerance of uncertainty. Ideal NA attenuated affect-health links for depressive symptoms and perceived stress. These findings point to the importance of sharpening the distinctions between various affect valuation constructs to elucidate their unique contributions to attenuating affect-health links.

A domain-differentiated approach to everyday emotion regulation from adolescence to older age.

Flexibly using different emotion-regulation (ER) strategies in different situational contexts, such as domains, has been argued to promote effective emotion regulation. Additionally, emotion regulation processes may change with age as narrowing time horizons shift emotion-regulation preferences. The purpose of the present study was to examine the occurrence and effectiveness of flexible emotion regulation in response to daily hassles from different domains within the age range from adolescence to old age. Participants, ranging from 14 to 88 years old (N = 325), completed an experience-sampling study of approximately 9 days over a 3-week period. At each momentary assessment, participants reported on their hassles, emotion-regulation strategies, and affect. As expected, strategy use varied across individuals and domains. For example, emotion expression and suppression were typical responses to interpersonal hassles, whereas social sharing was often used in response to work/school hassles. In situations wherein hassles included multiple life domains, participants reported the use of more emotion-regulation strategies than for single-domain hassles. Although flexible emotion regulation was evident in participants' responses to hassles, the expectation that it would be associated with lower hassle reactivity was not confirmed. These patterns were, for the most part, consistent across ages. This study contributes new insights into situational characteristics that are associated with emotion-regulation flexibility, showing that hassles domains are important for strategy selection, and that this holds from adolescence to old age. It also suggests that such defined emotion-regulation flexibility is not as strongly linked to emotion-regulation effectiveness as has been previously suggested. (PsycInfo Database Record (c) 2022 APA, all rights reserved).

Better With Age: Social Relationships Across Adulthood.

Older adults typically report higher levels of satisfaction with their social relationships than younger adults. The present paper integrates current developmental research to explain why social relationships are generally more positive with age. We discuss actions by older adults that contribute to more positive social experiences. We also include social role changes that may provide advantages for older adults when navigating their relationships. Next, we turn to interactional processes between older adults with their social partners. We review literature indicating that: (a) older adults engage in strategies that optimize positive social experiences and minimize negative ones by avoiding conflicts, and (b) social partners often reciprocate by treating older adults more positively and with greater forgiveness than they do younger adults.

Longitudinal coupling of momentary stress reactivity and trait neuroticism: Specificity of states, traits, and age period.

Personality traits like neuroticism show both continuity and change across adolescence and adulthood, with most pronounced changes occurring in young adulthood. It has been assumed, but insufficiently examined, that trait changes occur gradually over the years through the accumulation of daily experiences. The current longitudinal measurement burst study examined (a) how changes in average momentary stress reactivity are coupled with changes in trait neuroticism, (b) the extent to which this coupling is specific to stress reactivity and neuroticism, and (c) the extent to which there are age differences in the association between changes in stress reactivity and changes in neuroticism. Participants (N = 581; 50% male) between 14 and 86 years of age completed up to 3 waves (T1-T3) of Big Five trait questionnaires and experience-sampling assessments during 6 years. During each three-week experience-sampling period, participants reported their momentary affect and occurrences of hassles on average 55 times. Latent change models showed that increases over time in affective reactivity to daily hassles were associated with increases in neuroticism. This effect was consistent from T1 to T2 as well as from T2 to T3, and most pronounced in young adulthood. Importantly, the results were specific to associations between stress reactivity and neuroticism because changes in frequency of hassles in daily life did not predict changes in neuroticism, and stress reactivity did not consistently predict changes in the other Big Five traits. The findings help to inform theoretical models that outline how short-term states might contribute to gradual longer-term changes in traits like neuroticism. (PsycInfo Database Record (c) 2021 APA, all rights reserved).

Same old, same old? Age differences in the diversity of daily life.

Some research suggests that compared with younger adults, older adults have more homogeneous, less diverse daily life experiences because everyday situations and activities become increasingly stable and routine. However, strong empirical tests of this assumption are scarce. In two complementary studies, we examined whether older age is associated with less diversity in daily life experiences (e.g., regarding social interaction partners, activities, and places across and within days) and, if so, to what extent health limitations account for these age differences. In Study 1, we used daily diaries to investigate diversity across days among younger (N = 246; Mage = 21.8 years, SD = 2.5) and older adults (N = 119; Mage = 67.7 years, SD = 5.3). In Study 2, we investigated diversity within days employing experience sampling methods over three weeks in an adult life span sample (N = 365; range = 14-88 years). Results showed that across and within days, the daily lives of older adults were less diverse regarding their social interaction partners. Yet, older adults reported more diversity in activities within days and across days in the afternoons, whereas younger adults reported less diverse activities partly due to working or studying more often. Age differences remained statistically significant when controlling for health limitations. We conclude that age differences in the diversity of daily life are nuanced, depending on the domain and the level of analysis. (PsycInfo Database Record (c) 2020 APA, all rights reserved).

Daily interpersonal tensions and well-being among older adults: The role of emotion regulation strategies.

Interpersonal tensions are more strongly associated with well-being than other types of stressors in late life. Yet, there is little understanding of how older adults' preferences for different emotion regulation strategies may buffer or exacerbate effects of daily interpersonal tensions on emotional well-being. The present study examined links between interpersonal tensions and daily emotional well-being and whether those links were exacerbated or buffered by general emotion regulation strategy preferences. Participants were from the Daily Experiences and Well-Being Study, which included 293 older adults (aged 65 + years old) who completed baseline interviews, followed by 5-6 days of ecological momentary assessments, and a leave-behind questionnaire regarding emotion regulation strategies. Interpersonal tensions predicted poorer emotional well-being throughout the day and even more so for oldest-old individuals (aged 80 +) compared to young-old individuals. The effects of tensions on emotional well-being were attenuated among adults who generally preferred reappraisal and exacerbated among people who generally preferred avoidance. Reappraisal was particularly important for buffering the effects of tensions among individuals with poorer self-reported health. The findings regarding active coping were more nuanced and varied by age. The current study advances previous research on emotion regulation and social relations by examining older adults and revealing that links between interpersonal tensions, emotion regulation strategies, and emotional well-being vary on the basis of age and self-rated health. This study highlights the importance of considering how personal characteristics may shape later-life well-being in the context of coping with interpersonal tensions. (PsycInfo Database Record (c) 2020 APA, all rights reserved).

Conscientiousness, career success, and longevity: a lifespan analysis.

BACKGROUND: Markers of executive functioning, such as prudent planning for the future and impulse control, are related to conscientiousness and may be central to both occupational success and health outcomes. PURPOSE: The aim of the study was to examine relations among conscientiousness, career success, and mortality risk across a 65-year period. METHODS: Using data derived from 693 male participants in the Terman Life Cycle Study, we examined associations among childhood personality, midlife objective career success, and lifelong mortality risk through 2006. RESULTS: Conscientiousness and career success each predicted lower mortality risk (N = 693, relative hazard (rh) = 0.82 [95% confidence interval = 0.74, 0.91] and rh = 0.80 [0.71, 0.91], respectively), with both shared and unique variance. Importantly, childhood personality moderated the success-longevity link; conscientiousness was most relevant for least successful individuals. CONCLUSION: Conscientiousness and career success predicted longevity, but not in a straightforward manner. Findings highlight the importance of lifespan processes.

Now you see it, now you don't: age differences in affective reactivity to social tensions.

When faced with interpersonal conflict, older adults report using passive strategies more often than do young adults. They also report less affective reactivity in response to these tensions. We examined whether the use of passive strategies may explain age-related reductions in affective reactivity to interpersonal tensions. Over 8 consecutive evenings, participants (N = 1,031; 25-74 years-old) reported daily negative affect and the occurrence of tense situations resulting in an argument or avoidance of an argument. Older age was related to less affective reactivity when people decided to avoid an argument but was unrelated to affective reactivity when people engaged in arguments. Findings suggest that avoidance of negative situations may largely underlie age-related benefits in affective well-being.

Better Off Alone: Daily Solitude Is Associated With Lower Negative Affect in More Conflictual Social Networks.

BACKGROUND AND OBJECTIVES: Older adults are often considered at risk for social isolation. Little is known, however, about how often older adults lack social contact (in person, phone, electronic) throughout the day, the implications of lacking contact (i.e., solitude), and whether the effects of solitude vary by the broader social context. RESEARCH DESIGN AND METHODS: Participants were from the Daily Experiences and Well-being Study (DEWS) which included 313 older adults (aged 65+) who completed baseline interviews followed by 5-6 days of ecological momentary assessments approximately every 3 hr. RESULTS: Individuals reported having no social contact (i.e., solitude) on 11% of the occasions. Solitude predicted lower negative and positive affect on those occasions. The solitude-negative affect link varied by social network quality. Solitude predicted lower negative affect among individuals with more conflictual social networks but not among those with less conflictual networks. DISCUSSION AND IMPLICATIONS: Overall, solitude may serve as an adaptive strategy for individuals embedded in demanding or irritating social contexts.

Neuroticism and Extraversion Share Genetic and Environmental Effects with Negative and Positive Mood Spillover in a Nationally Representative Sample.

Work-family spillover research focuses on how negative and positive moods in one life domain carry over to another domain. Domain-specific etiologies (e.g., family conflict) are often emphasized to explain spillover. Yet, strong correlations exist between spillover variables of the same emotional valence and originating from different domains, suggesting individual differences in the tendencies to prolong mood-states. The current study (N=1143 individuals) examined whether these general tendencies are associated with neuroticism and extraversion, and how genetic and environmental effects contribute to these associations. Findings revealed that neuroticism and extraversion are related to these tendencies through genetic and environmental pathways.

Shall we marry? Legal marriage as a commitment event in same-sex relationships.

This study is a part of an exploratory study of 50 married and unmarried same-sex couples in Massachusetts conducted by the Wellesley Centers for Women following legalization of same-sex marriage in Massachusetts in 2004. This article examines whether and how legalization of same-sex marriage impacted same-sex partners' commitment to one another, presentation to others as a couple, and treatment as a couple by others. Roughly one-quarter of the couples studied chose not to mark their commitment with ceremonies of any kind, while nearly three-fourths of the couples had either commitment (non-legal) ceremonies, legal weddings, or both. While decisions to legally marry largely were based on gaining legal protections, unforeseen impacts on self and relationships with family, friends, and the larger society revealed multiple layers of meaning. Implications of the study for public policy and social change are discussed.

When bad moods may not be so bad: Valuing negative affect is associated with weakened affect-health links.

Bad moods are considered "bad" not only because they may be aversive experiences in and of themselves, but also because they are associated with poorer psychosocial functioning and health. We propose that people differ in their negative affect valuation (NAV; the extent to which negative affective states are valued as pleasant, useful/helpful, appropriate, and meaningful experiences) and that affect-health links are moderated by NAV. These predictions were tested in a life span sample of 365 participants ranging from 14-88 years of age using reports of momentary negative affect and physical well-being (via experience sampling) and assessments of NAV and psychosocial and physical functioning (via computer-assisted personal interviews and behavioral measures of hand grip strength). Our study demonstrated that the more individuals valued negative affect, the less pronounced (and sometimes even nonexistent) were the associations between everyday experiences of negative affect and a variety of indicators of poorer psychosocial functioning (i.e., emotional health problems, social integration) and physical health (i.e., number of health conditions, health complaints, hand grip strength, momentary physical well-being). Exploratory analyses revealed that valuing positive affect was not associated with the analogous moderating effects as NAV. These findings suggest that it may be particularly important to consider NAV in models of affect-health links.

Diurnal coupling between testosterone and cortisol from adolescence to older adulthood.

The hypothalamic-pituitary-adrenal (HPA) and hypothalamic-pituitary-gonadal (HPG) axes are typically conceptualized as mutually inhibitory systems; however, previous studies have found evidence for positive within-person associations (i.e., coupling) between cortisol and testosterone. One developmental hypothesis is that positive testosterone-cortisol coupling is unique to the adolescent period and that coupling becomes attenuated, or even switches direction, in adulthood. This study used a lifespan sample (N=292, ages 11-88) to test for age-related differences in coupling between cortisol and testosterone in daily life. Participants provided salivary hormone samples at waking, 30min after waking, and during the evening for two days. Hierarchical linear modeling was used to test the within-person and between-person associations between testosterone and cortisol. Within-person associations were further decomposed into associations due to coupled diurnal change versus coupled variability around diurnal change. Results indicated positive associations between cortisol and testosterone at all levels of analysis. Additionally, positive coupling was evident across the lifespan, even in older adults who are no longer expected to reproduce, but further investigation of developmental differences with a larger sample is necessary. Potential mechanisms and functions for positive coupling are discussed.

One size fits all? Applying theoretical predictions about age and emotional experience to people with functional disabilities.

The current study examined whether commonly observed age differences in affective experience among community samples of healthy adults would generalize to a group of adults who live with significant functional disability. Age differences in daily affect and affective reactivity to daily stressors among a sample of participants with spinal cord injury (SCI) were compared with a noninjured sample. Results revealed that patterns of affective experience varied by sample. Among noninjured adults, older age was associated with lower levels of daily negative affect, higher levels of daily positive affect, and less negative affective reactivity in response to daily stressors. In contrast, among the sample with SCI, no age differences emerged. Findings, which support the model of Strength and Vulnerability Integration, underscore the importance of taking life context into account when predicting age differences in affective well-being.