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1.
AJNR Am J Neuroradiol ; 37(7): 1347-53, 2016 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-26988814

RESUMO

BACKGROUND AND PURPOSE: Cerebral palsy is frequently associated with both motor and nonmotor symptoms. DTI can characterize the damage at the level of motor tracts but provides less consistent results in nonmotor areas. We used a standardized pipeline of analysis to describe and quantify the pattern of DTI white matter abnormalities of the whole brain in a group of children with chronic bilateral cerebral palsy and periventricular leukomalacia. We also explored potential correlations between DTI and clinical scale metrics. MATERIALS AND METHODS: Twenty-five patients (mean age, 11.8 years) and 25 healthy children (mean age, 11.8 years) were studied at 3T with a 2-mm isotropic DTI sequence. Differences between patients and controls were assessed both voxelwise and in ROIs obtained from an existing DTI atlas. Clinical metrics included the Gross Motor Function Classification System, the Manual Ability Classification System, and intelligence quotient. RESULTS: The voxel-level and ROI-level analyses demonstrated highly significant (P < .001) modifications of DTI measurements in patients at several levels: cerebellar peduncles, corticospinal tracts and posterior thalamic radiations, posterior corpus callosum, external capsule, anterior thalamic radiation, superior longitudinal fasciculi and corona radiata, optic nerves, and chiasm. The reduction of fractional anisotropy values in significant tracts was between 8% and 30%. Statistically significant correlations were found between motor impairment and fractional anisotropy in corticospinal tracts and commissural and associative tracts of the supratentorial brain. CONCLUSIONS: We demonstrated the involvement of several motor and nonmotor areas in the chronic damage associated with periventricular leukomalacia and showed new correlations between motor skills and DTI metrics.


Assuntos
Encéfalo/diagnóstico por imagem , Paralisia Cerebral/diagnóstico por imagem , Imagem de Tensor de Difusão/métodos , Substância Branca/diagnóstico por imagem , Anisotropia , Encéfalo/patologia , Paralisia Cerebral/etiologia , Paralisia Cerebral/patologia , Criança , Feminino , Humanos , Leucomalácia Periventricular/complicações , Leucomalácia Periventricular/diagnóstico por imagem , Leucomalácia Periventricular/patologia , Masculino , Substância Branca/patologia
2.
Methods Inf Med ; 55(1): 84-8, 2016.
Artigo em Inglês | MEDLINE | ID: mdl-26640835

RESUMO

INTRODUCTION: This article is part of the Focus Theme of Methods of Information in Medicine on "Methodologies, Models and Algorithms for Patients Rehabilitation". OBJECTIVES: The great potential of robots in extracting quantitative and meaningful data is not always exploited in clinical practice. The aim of the present work is to describe a simple parameter to assess the performance of subjects during upper limb robotic training exploiting data automatically recorded by the robot, with no additional effort for patients and clinicians. METHODS: Fourteen children affected by cerebral palsy (CP) performed a training with Armeo®Spring. Each session was evaluated with P, a simple parameter that depends on the overall performance recorded, and median and interquartile values were computed to perform a group analysis. RESULTS: Median (interquartile) values of P significantly increased from 0.27 (0.21) at T0 to 0.55 (0.27) at T1 . This improvement was functionally validated by a significant increase of the Melbourne Assessment of Unilateral Upper Limb Function. CONCLUSIONS: The parameter described here was able to show variations in performance over time and enabled a quantitative evaluation of motion abilities in a way that is reliable with respect to a well-known clinical scale.


Assuntos
Paralisia Cerebral/reabilitação , Reabilitação/métodos , Robótica , Extremidade Superior/fisiopatologia , Adolescente , Paralisia Cerebral/diagnóstico , Criança , Humanos , Pacientes Internados , Modalidades de Fisioterapia , Reprodutibilidade dos Testes , Tamanho da Amostra , Extremidade Superior/fisiologia
3.
Artigo em Inglês | MEDLINE | ID: mdl-26738003

RESUMO

The Gait Real-time Analysis Interactive Lab (GRAIL) is an instrumented multi-sensor platform based on immersive virtual reality for gait training and rehabilitation. Few studies have been included GRAIL to evaluate gait patterns in normal and disabled people and to improve gait in adults, while at our knowledge no evidence on its use for the rehabilitation of children is available. In this study, 4 children suffering from acquired brain injury (ABI) underwent a 5 session treatment with GRAIL, to improve walking and balance ability in engaging VR environments. The first and the last sessions were partially dedicated to gait evaluation. Results are promising: improvements were recorded at the ankle level, selectively at the affected side, and at the pelvic level, while small changes were measured at the hip and knee joints, which were already comparable to healthy subjects. All these changes also conveyed advances in the symmetry of the walking pattern. In the next future, a longer intervention will be proposed and more children will be enrolled to strongly prove the effectiveness of GRAIL in the rehabilitation of children with ABI.


Assuntos
Lesões Encefálicas/reabilitação , Marcha/fisiologia , Reabilitação/métodos , Interface Usuário-Computador , Caminhada/fisiologia , Tornozelo/fisiologia , Criança , Humanos , Pelve/fisiologia
4.
Annu Int Conf IEEE Eng Med Biol Soc ; 2015: 3590-3, 2015 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-26737069

RESUMO

Cerebral palsy (CP), one of the most common neurological disorders in childhood, features affected individual's motor skills and muscle actions. This results in elevated heart rate and rate of oxygen uptake during sub-maximal exercise, thus indicating a mean energy expenditure higher than healthy subjects. Rehabilitation, currently involving also robot-based devices, may have an impact also on these aspects. In this study, an ecological setting has been proposed to evaluate the energy expenditure of 4 children with CP before and after a robot-assisted gait training. Even if the small sample size makes it difficult to give general indications, results presented here are promising. Indeed, children showed an increasing trend of the energy expenditure per minute and a decreasing trend of the energy expenditure per step, in accordance to the control group. These data suggest a metabolic benefit of the treatment that may increase the locomotion efficiency of disabled children.


Assuntos
Paralisia Cerebral/terapia , Transtornos Neurológicos da Marcha/terapia , Atividades Cotidianas , Adolescente , Estudos de Casos e Controles , Paralisia Cerebral/metabolismo , Paralisia Cerebral/fisiopatologia , Criança , Crianças com Deficiência , Metabolismo Energético , Terapia por Exercício/instrumentação , Feminino , Marcha , Transtornos Neurológicos da Marcha/metabolismo , Transtornos Neurológicos da Marcha/fisiopatologia , Humanos , Masculino , Monitorização Ambulatorial , Destreza Motora , Robótica , Caminhada
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