Detalhe da pesquisa
1.
Discovery of a highly selective chemical inhibitor of matrix metalloproteinase-9 (MMP-9) that allosterically inhibits zymogen activation.
J Biol Chem
; 292(43): 17963-17974, 2017 10 27.
Artigo
Inglês
| MEDLINE | ID: mdl-28860188
2.
Discovery and cocrystal structure of benzodiazepinedione HDM2 antagonists that activate p53 in cells.
J Med Chem
; 48(4): 909-12, 2005 Feb 24.
Artigo
Inglês
| MEDLINE | ID: mdl-15715460
3.
Fusion to a highly stable consensus albumin binding domain allows for tunable pharmacokinetics.
Protein Eng Des Sel
; 28(10): 385-93, 2015 Oct.
Artigo
Inglês
| MEDLINE | ID: mdl-26275855
4.
Screening and characterization of human monoglyceride lipase active site inhibitors using orthogonal binding and functional assays.
J Biomol Screen
; 17(5): 629-40, 2012 Jun.
Artigo
Inglês
| MEDLINE | ID: mdl-22496098
5.
Crystal structure of a soluble form of human monoglyceride lipase in complex with an inhibitor at 1.35 Å resolution.
Protein Sci
; 20(4): 670-83, 2011 Apr.
Artigo
Inglês
| MEDLINE | ID: mdl-21308848
6.
Enhanced pharmacokinetic properties of 1,4-benzodiazepine-2,5-dione antagonists of the HDM2-p53 protein-protein interaction through structure-based drug design.
Bioorg Med Chem Lett
; 16(12): 3310-4, 2006 Jun 15.
Artigo
Inglês
| MEDLINE | ID: mdl-16600594
7.
1,4-Benzodiazepine-2,5-diones as small molecule antagonists of the HDM2-p53 interaction: discovery and SAR.
Bioorg Med Chem Lett
; 15(3): 765-70, 2005 Feb 01.
Artigo
Inglês
| MEDLINE | ID: mdl-15664854
8.
Design and synthesis of 4,5-disubstituted-thiophene-2-amidines as potent urokinase inhibitors.
Bioorg Med Chem Lett
; 12(3): 491-5, 2002 Feb 11.
Artigo
Inglês
| MEDLINE | ID: mdl-11814826