Detalhe da pesquisa
1.
Discovery of 2-(1H-indol-5-ylamino)-6-(2,4-difluorophenylsulfonyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one (7ao) as a potent selective inhibitor of Polo like kinase 2 (PLK2).
Bioorg Med Chem
; 24(4): 521-44, 2016 Feb 15.
Artigo
Inglês
| MEDLINE | ID: mdl-26762835
2.
Hydrothiolation of benzyl mercaptan to arylacetylene: application to the synthesis of (E) and (Z)-isomers of ON 01910·Na (Rigosertib®), a phase III clinical stage anti-cancer agent.
Org Biomol Chem
; 11(12): 1964-77, 2013 Mar 28.
Artigo
Inglês
| MEDLINE | ID: mdl-23386308
3.
Design, synthesis and evaluation of (E)-alpha-benzylthio chalcones as novel inhibitors of BCR-ABL kinase.
Bioorg Med Chem
; 18(6): 2317-2326, 2010 Mar 15.
Artigo
Inglês
| MEDLINE | ID: mdl-20188579
4.
Design, synthesis, and biological evaluation of (E)-styrylbenzylsulfones as novel anticancer agents.
J Med Chem
; 51(1): 86-100, 2008 Jan 10.
Artigo
Inglês
| MEDLINE | ID: mdl-18088089
5.
Design, synthesis, and biological evaluation of 1-(4-sulfamylphenyl)-3-trifluoromethyl-5-indolyl pyrazolines as cyclooxygenase-2 (COX-2) and lipoxygenase (LOX) inhibitors.
Bioorg Med Chem
; 16(7): 3907-16, 2008 Apr 01.
Artigo
Inglês
| MEDLINE | ID: mdl-18272371
6.
Discovery of 8-cyclopentyl-2-[4-(4-methyl-piperazin-1-yl)-phenylamino]-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidine-6-carbonitrile (7x) as a potent inhibitor of cyclin-dependent kinase 4 (CDK4) and AMPK-related kinase 5 (ARK5).
J Med Chem
; 57(3): 578-99, 2014 Feb 13.
Artigo
Inglês
| MEDLINE | ID: mdl-24417566
7.
Design, synthesis, and biological evaluation of (E)-N-aryl-2-arylethenesulfonamide analogues as potent and orally bioavailable microtubule-targeted anticancer agents.
J Med Chem
; 56(13): 5562-86, 2013 Jul 11.
Artigo
Inglês
| MEDLINE | ID: mdl-23750455
8.
(Z)-1-aryl-3-arylamino-2-propen-1-ones, highly active stimulators of tubulin polymerization: synthesis, structure-activity relationship (SAR), tubulin polymerization, and cell growth inhibition studies.
J Med Chem
; 55(11): 5174-87, 2012 Jun 14.
Artigo
Inglês
| MEDLINE | ID: mdl-22587519
9.
Discovery of a clinical stage multi-kinase inhibitor sodium (E)-2-{2-methoxy-5-[(2',4',6'-trimethoxystyrylsulfonyl)methyl]phenylamino}acetate (ON 01910.Na): synthesis, structure-activity relationship, and biological activity.
J Med Chem
; 54(18): 6254-76, 2011 Sep 22.
Artigo
Inglês
| MEDLINE | ID: mdl-21812421
10.
Novel coumarin-3-(N-aryl)carboxamides arrest breast cancer cell growth by inhibiting ErbB-2 and ERK1.
Bioorg Med Chem
; 13(9): 3141-7, 2005 May 02.
Artigo
Inglês
| MEDLINE | ID: mdl-15809149