[The diagnostic detection of sIgE to allergens of trees' pollen by rest-system «Alkor-Bio¼ and Immunocap technique.]

The article presents the results of preliminary analysis of 320 pair results of testing of children with bronchial asthma and/or allergic rhinitis conditioned by tree pollen. The imported and national test-systems ImmunoCAP and Alkor-Bio were applied. The detailed analysis of study results of the mentioned tests demonstrated that detection of levels of allergen-specific IgE in patients using test-systems Alkor-Bio and ImmunoCAP shows high degree of data matching related to a number of tree allergens. The application of national test-system Alkor-Bio can be considered as an alternative to import methods in evaluation of levels of sIgE to allergens of alder tree, birch, hazel, willow, poplar, pine.

[The mode of evaluation of sensibilization of children to grain herbs under respiratory allergy.]

The sensibilization of patients to allergens of grain herbs is characterized by expressed crossed allergic reactions to pollen of various representatives of the given family. The investigation of antibody response to allergens of grain herbs and also data of epidemiological studies, results of world and national studies permitted to develop and propose a new mode of diagnostic of allergy with evaluation of level of sensibilization of patient and also qualitative detection in blood serum the level of specific immunoglobulins E (IgE) to allergens of grain herbs. The parameter «concentration of IgE to allergens of cocksfoot¼ - IgE(g3) - is a key one for evaluating in blood serum of patients content of IgE to allergens of grain herbs matched to cocksfoot: randall, timothy, Kentucky bluegrass, field brome, meadow foxtail, French ryegrass. To calculate concentration of IgE to allergens of the mentioned grasses detection of IgE(g3) is necessary and sufficient. The elaborated prognostic table permits evaluating degree of ensibilization of patient to various grain herbs and also detecting concentration of IgE expressed in units kE per l without application of additional serological analyses. Therefore, the elaborated technique permits reducing number of «in vitro¼ tests and minimizing number of blood sample of patient and also speeding up receiving of information concerning sensibilization profile of patient.

[The clinical significance of determining the HLA-DR4 antigen in patients with breast cancer]. / Klinicheskoe znachenie opredeleniia antigena HLA-DR4 u bol'nykh rakom molochnoi zhelezy.

A study of HLA phenotype in 151 cases of breast cancer showed an increased occurrence of DR4 antigen (46.8%) as compared to general population (16.3%). Some clinical parameters of DR4-positive and DR4-negative patients were compared. Estradiol receptor-negative tumor was observed in 40% of DR4-positive patients and only in 18.5% of estradiol receptor-negative ones. DR4 positivity was associated with poorer prognosis.

[Development of technical aids in ultrasonic diapeutics and experience in their use in public health of Udmurt]. / Razrabotka tekhnicheskikh sredstv ul'trazvukovoi diapevtiki i opyt ikh primeneniia v zdravookhranenii Udmurtii.

Analysing the physicians' comments on ultrasonic diagnostic devices revealed it necessary to adapt the routine transducers of these devices for diapeutical interventions. High-echogenicity needles that direct devices for their performance (holders) and special adapters have been designed.

[Atopic dermatitis. I. Characteristics of the clinical course and state of the immune status in relation to the initial level of serum IgE]. / Atopicheskii dermatit. I. Osobennosti klinicheskogo techeniia i sostoianiia immunnogo statusa v zavisimosti ot iskhodnogo urovnia IgE syvorotki.

Altogether 97 patients with atopic dermatitis have been examined to follow this relationship, 72 patients presented with disseminated efflorescence, 25 patients with local rash. Measurements of immunoglobulins A, M, G, and D, of the C3c complement components, of the total and allergen-specific IgE C4, inactivators have been carried out, as well as of the total lymphocyte, B lymphocyte, and CD3+, CD4+, and CD8+ lymphocyte subpopulations; the lymphocyte response to ConA mitogenic stimulation has been also under study. The patients with normal and elevated levels of IgE differed by the clinical picture of the disease and by case histories, as well as by the immunity parameters and by the results of zaditen therapy. Cases with very low IgE levels may be indicative of alternative pathogenetic mechanisms.