Detalhe da pesquisa
1.
Glucocorticoids promote breast cancer metastasis.
Nature
; 567(7749): 540-544, 2019 03.
Artigo
Inglês
| MEDLINE | ID: mdl-30867597
2.
Molecular characterization of chronic cutaneous wounds reveals subregion- and wound type-specific differential gene expression.
Int Wound J
; 21(4): e14447, 2024 Apr.
Artigo
Inglês
| MEDLINE | ID: mdl-38149752
3.
Drug Design and Success of Prospective Mouse In Vitro-In Vivo Extrapolation (IVIVE) for Predictions of Plasma Clearance (CLp) from Hepatocyte Intrinsic Clearance (CLint).
Mol Pharm
; 20(7): 3438-3459, 2023 07 03.
Artigo
Inglês
| MEDLINE | ID: mdl-37235687
4.
Computational Predictions of Nonclinical Pharmacokinetics at the Drug Design Stage.
J Chem Inf Model
; 63(2): 442-458, 2023 01 23.
Artigo
Inglês
| MEDLINE | ID: mdl-36595708
5.
Can We Predict Clinical Pharmacokinetics of Highly Lipophilic Compounds by Integration of Machine Learning or In Vitro Data into Physiologically Based Models? A Feasibility Study Based on 12 Development Compounds.
Mol Pharm
; 19(11): 3858-3868, 2022 11 07.
Artigo
Inglês
| MEDLINE | ID: mdl-36150125
6.
Evaluation of In Vitro Models for Assessment of Human Intestinal Metabolism in Drug Discovery.
Drug Metab Dispos
; 48(11): 1169-1182, 2020 11.
Artigo
Inglês
| MEDLINE | ID: mdl-32862146
7.
Qualification of impurities based on metabolite data.
Regul Toxicol Pharmacol
; 110: 104524, 2020 Feb.
Artigo
Inglês
| MEDLINE | ID: mdl-31734179
8.
Functional assessment of rat pulmonary flavin-containing monooxygenase activity.
Xenobiotica
; 49(5): 503-512, 2019 May.
Artigo
Inglês
| MEDLINE | ID: mdl-29694257
9.
Assessment of the pulmonary CYP1A1 metabolism of mavoglurant (AFQ056) in rat.
Xenobiotica
; 48(8): 793-803, 2018 Aug.
Artigo
Inglês
| MEDLINE | ID: mdl-28879796
10.
Discovery of an MLLT1/3 YEATS Domain Chemical Probe.
Angew Chem Int Ed Engl
; 57(50): 16302-16307, 2018 12 10.
Artigo
Inglês
| MEDLINE | ID: mdl-30288907
11.
A UGT2B10 splicing polymorphism common in african populations may greatly increase drug exposure.
J Pharmacol Exp Ther
; 352(2): 358-67, 2015 Feb.
Artigo
Inglês
| MEDLINE | ID: mdl-25503386
12.
Phase II metabolism in human skin: skin explants show full coverage for glucuronidation, sulfation, N-acetylation, catechol methylation, and glutathione conjugation.
Drug Metab Dispos
; 43(1): 126-39, 2015 Jan.
Artigo
Inglês
| MEDLINE | ID: mdl-25339109
13.
Aldehyde oxidase activity in fresh human skin.
Drug Metab Dispos
; 42(12): 2049-57, 2014 Dec.
Artigo
Inglês
| MEDLINE | ID: mdl-25249692
14.
Another string to your bow: machine learning prediction of the pharmacokinetic properties of small molecules.
Expert Opin Drug Discov
; 19(6): 683-698, 2024 Jun.
Artigo
Inglês
| MEDLINE | ID: mdl-38727016
15.
Discovery of Orally Available and Brain Penetrant AEP Inhibitors.
J Med Chem
; 66(24): 17026-17043, 2023 12 28.
Artigo
Inglês
| MEDLINE | ID: mdl-38090813
16.
UDP-glucuronic acid binds first and the aglycone substrate binds second to form a ternary complex in UGT1A9-catalyzed reactions, in both the presence and absence of bovine serum albumin.
Drug Metab Dispos
; 40(11): 2192-203, 2012 Nov.
Artigo
Inglês
| MEDLINE | ID: mdl-22912433
17.
Bovine serum albumin decreases Km values of human UDP-glucuronosyltransferases 1A9 and 2B7 and increases Vmax values of UGT1A9.
Drug Metab Dispos
; 39(11): 2117-29, 2011 Nov.
Artigo
Inglês
| MEDLINE | ID: mdl-21856742
18.
Glucuronidation of psilocin and 4-hydroxyindole by the human UDP-glucuronosyltransferases.
Drug Metab Dispos
; 38(3): 386-95, 2010 Mar.
Artigo
Inglês
| MEDLINE | ID: mdl-20007669
19.
Metabolism by Aldehyde Oxidase: Drug Design and Complementary Approaches to Challenges in Drug Discovery.
J Med Chem
; 62(24): 10955-10994, 2019 12 26.
Artigo
Inglês
| MEDLINE | ID: mdl-31385704
20.
Comparison of Rat and Human Pulmonary Metabolism Using Precision-cut Lung Slices (PCLS).
Drug Metab Lett
; 13(1): 53-63, 2019.
Artigo
Inglês
| MEDLINE | ID: mdl-30345935