Right ventricular ischemic injury in patients with acute ST-segment elevation myocardial infarction: characterization with cardiovascular magnetic resonance.

BACKGROUND: Experimental data show that the right ventricle (RV) is more resistant to ischemia than the left ventricle. To date, limited data are available in humans because of the difficulty of discriminating reversible from irreversible ischemic damage. We sought to characterize RV ischemic injury in patients with reperfused myocardial infarction using cardiovascular magnetic resonance. METHODS AND RESULTS: In 3 tertiary centers, 242 consecutive patients with reperfused acute ST-segment elevation myocardial infarction were studied with cardiovascular magnetic resonance at 1 week and 4 months after myocardial infarction. T2-weighted and postcontrast cardiovascular magnetic resonance scans were used to depict myocardial edema and late gadolinium enhancement, respectively. Early after infarction, RV edema was common (51% of patients), often associated with late gadolinium enhancement (31% of patients). Remarkably, RV edema and late gadolinium enhancement were found in 33% and 12% of anterior left ventricular infarcts, respectively. Baseline regional and global RV functions were inversely related to the presence and extent of RV edema and RV late gadolinium enhancement. At follow-up, a significant decrease in frequency (25/242 patients; 10%) and extent of RV late gadolinium enhancement was observed (P<0.001). With the use of multivariable analysis, the presence of RV edema was an independent predictor of RV global function improvement during follow-up (ß-coefficient=0.221, P=0.003). CONCLUSIONS: Early postinfarction RV ischemic injury is common and is characterized by the presence of myocardial edema, late gadolinium enhancement, and functional abnormalities. RV injury is not limited to inferior infarcts but is commonly found in anterior infarcts as well. Cardiovascular magnetic resonance findings suggest reversibility of acute RV dysfunction with limited permanent myocardial damage at 4-month follow-up.

Optimizing radiation dose and image quality.

Radiation exposure is a critical issue in multidetector CT (MDCT) particularly since fast MDCT scanners have become widely available, and the method has been proposed as a noninvasive diagnostic tool for an increasing number of clinical applications. Additional features of MDCT imaging affecting individual dose are related to the inappropriate use of scanners caused by practices such as scanning beyond the area of interest or acquiring unnecessary multiphase image sets. In order to reduce individual exposure and in accordance with the ALARA principle, several strategies have been implemented over the last few years which are based on X-ray emission or optimization of scanning parameters (i.e. mAs, kV, pitch, collimation) or which take account of the individual patient's characteristics (automatic exposure control systems and ECG-pulsing techniques for ECG-gated acquisitions). These strategies allow optimization of image quality while keeping individual exposure at the lowest level. We review here these different strategies taking into account the relationship between image noise and different scanning parameters. Data from the literature are discussed, and current technological developments are considered, including initial results of dual source and SnapShot pulse technologies which have been shown to result in a significant dose reduction in ECG-gated cardiac acquisitions without compromising image quality.